Family Search for PF09313 (DUF1971)

PF09313 hits 20 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TEHB_HAEIN / P45134 Probable S-adenosyl-L-methionine-dependent methyltransferase TehB; Tellurite resistance protein TehB homolog; EC 2.1.1.- from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
Aligns to 9:89 / 286 (28.3%), covers 100.0% of PF09313, 114.4 bits

• function: Probable S-adenosyl-L-methionine-dependent methyltransferase. Plays a role in both resistance to oxidative damage and heme uptake/utilization. Also protects H.influenzae from tellurite exposure in vitro; however, since H.influenzae grows only in humans, it is unlikely to encounter tellurite in its natural environment, and it is thus probable that tellurite resistance does not represent a biologically relevant role of TehB (By similarity).

TEHB_HAEI1 / E1X791 Probable S-adenosyl-L-methionine-dependent methyltransferase TehB; Tellurite resistance protein TehB homolog; EC 2.1.1.- from Haemophilus influenzae (strain 10810) (see paper)
Aligns to 9:89 / 286 (28.3%), covers 100.0% of PF09313, 111.6 bits

• function: Probable S-adenosyl-L-methionine-dependent methyltransferase. Plays a role in both resistance to oxidative damage and heme uptake/utilization, and is important for virulence of this organism in an animal model of invasive disease. Also protects H.influenzae from tellurite exposure in vitro; however, since H.influenzae grows only in humans, it is unlikely to encounter tellurite in its natural environment, and it is thus probable that tellurite resistance does not represent a biologically relevant role of TehB.
  disruption phenotype: Deletion of tehB leads to an increase in sensitivity both to tellurite and to the oxidizing agents cumene hydroperoxide, tert-butyl hydroperoxide and hydrogen peroxide. The tehB mutant additionally shows a significantly reduced ability to utilize free heme as well as several heme-containing moieties including heme- human serum albumin, hemoglobin and hemoglobin-haptoglobin, to support aerobic growth. Virulence of the mutant strain is reduced compared to the wild-type strain in the infant rat.

YeaR / b1797 DUF1971 domain-containing protein YeaR from Escherichia coli K-12 substr. MG1655 (see 4 papers)
Aligns to 12:96 / 119 (71.4%), covers 100.0% of PF09313, 79.5 bits

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