Family Search for PF10154 (DUF2362)

PF10154 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

FERY3_HUMAN / Q9NQ89 Ferry endosomal RAB5 effector complex subunit 3; Fy-3 from Homo sapiens (Human) (see 4 papers)
Aligns to 41:546 / 552 (91.7%), covers 99.6% of PF10154, 735.5 bits

• function: Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA- interaction (PubMed:37267905). Plays a role in mast cell degranulation.
  subunit: Component of the FERRY complex composed of five subunits, TBCK, PPP1R21, FERRY3, CRYZL1 and GATD1 with a ratio of 1:2:1:2:4, respectively.

FERY3_RAT / D4A770 FERRY endosomal RAB5 effector complex subunit 3 from Rattus norvegicus (Rat) (see paper)
Aligns to 41:546 / 552 (91.7%), covers 99.6% of PF10154, 728.7 bits

• function: Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (By similarity). Plays a role in mast cell degranulation (PubMed:25122211).
  subunit: Component of the FERRY complex composed of five subunits, TBCK, PPP1R21, FERRY3, CRYZL1 and GATD1 with a ratio of 1:2:1:2:4, respectively.

Or search for genetic data about PF10154 in the Fitness Browser