Family Search for PF10574 (UPF0552)

PF10574 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

ARPIN_DANRE / Q1LWJ6 Arpin from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 1:224 / 226 (99.1%), covers 100.0% of PF10574, 396.6 bits

• function: Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors (By similarity). Involved in steering cell migration by controlling its directional persistence.
  subunit: Associates with the Arp2/3 complex.

ARPIN_HUMAN / Q7Z6K5 Arpin; Arp2/3 inhibition protein from Homo sapiens (Human) (see paper)
Aligns to 1:224 / 226 (99.1%), covers 100.0% of PF10574, 373.5 bits

• function: Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
  subunit: Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.

ARPIN_MOUSE / Q9D0A3 Arpin; Arp2/3 inhibition protein from Mus musculus (Mouse) (see paper)
Aligns to 1:224 / 226 (99.1%), covers 100.0% of PF10574, 372.5 bits

• function: Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity).
  subunit: Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.

ARPIN_DICDI / Q54F87 Arpin from Dictyostelium discoideum (Social amoeba) (see paper)
Aligns to 1:223 / 224 (99.6%), covers 93.3% of PF10574, 91.9 bits

• function: Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex (By similarity). Involved in steering cell migration by controlling its directional persistence.
  subunit: Associates with the Arp2/3 complex.

Or search for genetic data about PF10574 in the Fitness Browser