Family Search for PF10998 (DUF2838)

PF10998 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

GPC1_SCHPO / O94673 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 111:221 / 403 (27.5%), covers 100.0% of PF10998, 147.1 bits

• function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (By similarity). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (By similarity). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (By similarity). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (By similarity). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (By similarity).
  catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn- glycero-3-phosphocholine + CoA (RHEA:58476)
  catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)
  catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA (RHEA:62104)

GPC1_YEAST / P48236 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
Aligns to 112:222 / 432 (25.7%), covers 100.0% of PF10998, 143.7 bits

• function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:18430972, PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:18430972, PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859). Involved in postsynthetic PC remodeling that produces more saturated PC species (PubMed:30514764).
  catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn- glycero-3-phosphocholine + CoA (RHEA:58476)
  catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)
  catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA (RHEA:62104)
  catalytic activity: hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine (RHEA:56148)
  catalytic activity: (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56152)
  catalytic activity: (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3- phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA (RHEA:56156)
  catalytic activity: (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3- phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3- phosphocholine + CoA (RHEA:56164)
  catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z- octadecenoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56168)
  catalytic activity: 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn- glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3- phosphocholine + sn-glycero-3-phosphoethanolamine (RHEA:56236)
  disruption phenotype: Decreases the levels of monounsaturated PC species and increased those of diunsaturated PC species. Does not significantly affect phosphatidylethanolamine, phosphatidylinositol, and phosphatidylserine profiles.

GPC1_ARATH / Q9FJB4 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 66:176 / 381 (29.1%), covers 99.1% of PF10998, 131.5 bits

• function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859).
  catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn- glycero-3-phosphocholine + CoA (RHEA:58476)
  catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)
  catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z- octadecenoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56168)

GPC1_RICCO / B9RK42 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Ricinus communis (Castor bean) (see paper)
Aligns to 69:179 / 391 (28.4%), covers 99.1% of PF10998, 131.0 bits

• function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859).
  catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a monoacyl-sn- glycero-3-phosphocholine + CoA (RHEA:58460)
  catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)
  catalytic activity: hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine (RHEA:56148)
  catalytic activity: (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z- hexadecenoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56228)
  catalytic activity: (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56152)
  catalytic activity: (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3- phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA (RHEA:56156)
  catalytic activity: (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3- phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3- phosphocholine + CoA (RHEA:56164)
  catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z- octadecenoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56168)

GPC1_BRANA / A0A078H868 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Brassica napus (Rape) (see paper)
Aligns to 70:180 / 387 (28.7%), covers 99.1% of PF10998, 130.0 bits

• function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859).
  catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn- glycero-3-phosphocholine + CoA (RHEA:58476)
  catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)

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