Family Search for PF11119 (DUF2633)

PF11119 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

BWI76_RS21010 Negative regulator of nickel and cobalt uptake (YfgG) from Klebsiella michiganensis M5al
Aligns to 1:43 / 63 (68.3%), covers 100.0% of PF11119, 99.8 bits

• mutant phenotype: Specifically important in stress Nickel (II) chloride hexahydrate, and also important for cobalt stress. Similar to E.coli yfgG, which has similar phenotypes. Both orthologs have strong negative cofitness with the Mg/Ni/Co transporter corA (BWI76_RS01225). BWI76_RS21010 is a putative small membrane protein and might inhibit corA or reduce its abundance (by analogy to the magnesium transporter MtgE and the small membrane protein MtgS that binds and stabilizes MtgS).

b2504 Negative regulator of nickel and cobalt uptake (YfgG) from Escherichia coli BW25113
YfgG / b2504 nickel/cobalt stress response protein YfgG from Escherichia coli K-12 substr. MG1655 (see 3 papers)
YFGG_ECOLI / P64545 Protein YfgG from Escherichia coli (strain K12) (see paper)
Aligns to 7:49 / 63 (68.3%), covers 100.0% of PF11119, 98.2 bits

• mutant phenotype: YfgG is important for resisting cobalt and nickel stress, as is its ortholog in Klebsiella (BWI76_RS21010). Furthermore, overexpression of yfgG confers increased resistance to cobalt (PMID:30659179). YfgG has strong negative cofitness with the Mg/Ni/Co transporter corA, as does its ortholog in Klebsiella. YfgG is a small putative membrane protein and might bind corA to inhibit it or reduce its abundance (by analogy to the magnesium transporter MtgE and the small membrane protein MtgS that binds and stabilizes MtgS.)

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