Family Search for PF11816 (DUF3337)

Running HMMer for PF11816

PF11816 hits 12 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

WDR48_HUMAN / Q8TAF3 WD repeat-containing protein 48; USP1-associated factor 1; WD repeat endosomal protein; p80 from Homo sapiens (Human) (see 18 papers)
Aligns to 509:674 / 677 (24.5%), covers 99.4% of PF11816, 162.0 bits

• function: Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029, PubMed:31253762). Enhances the USP1- mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27373336, PubMed:27650958). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27239033, PubMed:27463890, PubMed:32350107). Binds single- stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51- mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045).
  function: (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase- interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488).
  subunit: Interacts with USP46 (PubMed:19075014, PubMed:26388029). Interacts with USP1 (PubMed:18082604, PubMed:26388029). Interacts with USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). Component of the USP12-WDR20-WDR48 deubiquitinating complex (PubMed:27373336). Component of the USP12-DMWD-WDR48 deubiquitinating complex (PubMed:33844468). Interacts with PHLPP1 (PubMed:24145035). Interacts with RAD51AP1; the interaction is direct and promotes formation of a trimeric complex with RAD51 via RAD51AP1 (PubMed:27239033, PubMed:27463890). Interacts with ATAD5; the interaction regulates USP1- mediated PCNA deubiquitination (PubMed:20147293). Interacts with RAD51; the interaction is enhanced under replication stress (PubMed:31844045). Interacts with ITCH; the interaction is more efficient when both USP12 and WDR48/UAF1 are involved and may facilitate recruitment of the USP12 deubiquitinating complex to Notch (PubMed:22778262).
  subunit: (Microbial infection) Interacts with papillomavirus HPV11 E1 protein.
  subunit: (Microbial infection) Interacts with Saimiriine herpesvirus TIP protein.
  subunit: (Microbial infection) Interacts with human cytomegalovirus protein UL138.
  subunit: (Microbial infection) Interacts with Epstein-Barr virus protein EBNA3.

WDR48_DROME / Q1LZ08 WD repeat-containing protein 48 homolog; USP1-associated factor 1 from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 492:659 / 668 (25.1%), covers 99.4% of PF11816, 161.0 bits

• function: Regulatory component of the Usp12-46 deubiquitylase complex (PubMed:37798281). activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity). The complex deubiquitylates the wg/wingless-signaling receptor arr/arrow, which stabilizes the receptor and increases its concentration at the cell surface; this enhances the sensitivity of cells to wg/wingless-signal stimulation (PubMed:37798281). This increases the amplitude and spatial range of the signaling response to the wg/wingless morphogen gradient, facilitating the precise concentration-dependent regulation of its target genes (PubMed:37798281). Together with Wdr20 and Usp12-46 required for wg/wingless-mediated signaling in the wing imaginal disc and for wg/wingless-dependent regulation of intestinal stem cell proliferation (PubMed:37798281).
  subunit: Catalytic component of the Usp12-46 deubiquitylase complex consisting of Usp12-46, Wdr20 and Uaf1; regulatory subunit that, together wtih Wdr20, stabilizes Usp12-46 (PubMed:37798281). The Usp12- 46 deubiquitylase complex associates with arr/arrow; the interaction leads to deubiquitination and stabilization of arr/arrow (PubMed:37798281).
  disruption phenotype: Viable but sterile with reduced lifespan.

BU107_SCHPO / Q09731 UBP9-binding protein bun107; Binding ubp9 protein of 107 kDa from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 798:945 / 962 (15.4%), covers 98.8% of PF11816, 151.8 bits

• function: Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations.
  subunit: Interacts with ubp9 and bun62.

WDR48_CAEEL / Q20059 WD repeat-containing protein 48 homolog from Caenorhabditis elegans (see paper)
Aligns to 530:681 / 683 (22.3%), covers 99.4% of PF11816, 135.1 bits

• function: Together with wdr-20, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.
  subunit: Interacts with usp-46; the interaction increases the catalytic activity of usp-46 in the presence of wdr-20.
  disruption phenotype: Changed locomotion behavior with mutants displaying decreased reversal frequencies consistent with decreased glutamergic signaling.

DUF1_YEAST / Q99247 DUB-associated factor 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
Aligns to 876:1099 / 1116 (20.1%), covers 82.0% of PF11816, 109.7 bits

• function: Ubiquitin-binding protein involved in the resistance to phenanthroline, sanguinarine, nordihydroguaiaretic acid (NDGA), isopropyl (N-3-chloro-phenyl)-carbamate (IPCPC) and guanosine 5'-O-(2- thiodiphosphate).
  subunit: Interacts (via its WD repeats) with ubiquitin.

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