Family Search for PF11938 (DUF3456)

PF11938 hits 33 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

CNPY1_DANRE / Q2L6L1 Protein canopy-1; Protein D121 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 31:177 / 187 (78.6%), covers 100.0% of PF11938, 161.0 bits

• function: Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development.
  subunit: Homodimer. Interacts with fgfr1.

CNPY2_HUMAN / Q9Y2B0 Protein canopy homolog 2; MIR-interacting saposin-like protein; Putative secreted protein Zsig9; Transmembrane protein 4 from Homo sapiens (Human) (see paper)
Aligns to 27:171 / 182 (79.7%), covers 100.0% of PF11938, 159.8 bits

• function: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation
  subunit: Interacts with MYLIP/MIR.

CNPY4_DANRE / Q2L6K8 Protein canopy 4 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 26:185 / 217 (73.7%), covers 100.0% of PF11938, 151.4 bits

CNPY4_MOUSE / Q8BQ47 Protein canopy homolog 4; Protein associated with Tlr4 from Mus musculus (Mouse) (see paper)
Aligns to 43:202 / 245 (65.3%), covers 98.0% of PF11938, 150.1 bits

• function: Plays a role in the regulation of the cell surface expression of TLR4.
  subunit: Interacts with TLR4.

CNPY3_MOUSE / Q9DAU1 Protein canopy homolog 3; Protein associated with Tlr4; Trinucleotide repeat-containing gene 5 protein from Mus musculus (Mouse) (see 6 papers)
Aligns to 48:206 / 276 (57.6%), covers 98.0% of PF11938, 148.8 bits

• function: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses.
  subunit: Interacts with HSP90B1; this interaction is disrupted in the presence of ATP. Interacts with TLR1, TLR2, TLR4 and TLR9. Strongest interaction with TLR4.
  disruption phenotype: The birth rate of knockout mice on a C57BL/6 background is very low (approximately 10% of pups). The animals appear normal, but their growth after birth is severely retarded. Half of them die by the end of the weaning period. Mutant mice have profoundly impaired T-helper type 1 lymphocyte (Th1)-mediated responses (PubMed:17998391). On a BALB/c background, under resting conditions, they show spastic or dystonic features and, during the open field test, they exhibit hyperactivity and anxiety. Their resting electroencephalography show enhanced activity in the fast beta frequency band (20-35 Hz). They do not show any apparent structural brain anomaly (PubMed:29394991).

CNPY4_HUMAN / Q8N129 Protein canopy homolog 4 from Homo sapiens (Human) (see paper)
Aligns to 37:196 / 248 (64.5%), covers 97.3% of PF11938, 148.6 bits

• function: Plays a role in the regulation of the cell surface expression of TLR4.
  subunit: Interacts with TLR4.

CNPY3_HUMAN / Q9BT09 Protein canopy homolog 3; CTG repeat protein 4a; Expanded repeat-domain protein CAG/CTG 5; Protein associated with TLR4; Trinucleotide repeat-containing gene 5 protein from Homo sapiens (Human) (see paper)
Aligns to 48:206 / 278 (57.2%), covers 98.0% of PF11938, 147.3 bits

• function: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).
  subunit: Interacts with HSP90B1; this interaction is disrupted in the presence of ATP. Interacts with TLR1, TLR2, TLR4 and TLR9 (By similarity). Strongest interaction with TLR4 (By similarity).

CNPY3_DANRE / A3KNS2 Protein canopy homolog 3; Trinucleotide repeat-containing gene 5 protein from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 31:190 / 276 (58.0%), covers 97.3% of PF11938, 145.0 bits

• function: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity).

SEELE_DROME / Q7JXF7 Protein seele from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 26:172 / 189 (77.8%), covers 100.0% of PF11938, 130.1 bits

• function: Involved in embryonic dorsal-ventral patterning which is generated by a series of serine protease processing events where gd processes snk which cleaves ea which then processes spz into the activating ligand for the Toll receptor. Required during this process for the secretion of ea from the developing embryo into the perivitelline space and for ea processing.
  disruption phenotype: Formation of embryos with altered dorsal-ventral patterning, dramatically decreased levels of ea in the perivitelline space and reduced processing of ea.

CREL1_CAEEL / Q19267 Protein disulfide isomerase crld-1; Cysteine-rich with EGF-like domain protein crld-1; EC 5.3.4.1 from Caenorhabditis elegans (see paper)
2 alignments in 26:135 / 356 (30.9%), covering up to 42.0% of PF11938, 50.3 bits

• function: Protein disulfide isomerase which associates with the unc-29 subunit of levamisole-sensitive nicotinic acetylcholine receptors (L- nAChR) to promote L-nAChR assembly in the endoplasmic reticulum at neuromuscular junctions.
  function: [Isoform a]: Promotes L-nAChR assembly in the endoplasmic reticulum at neuromuscular junctions.
  catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins.
  subunit: Interacts with unc-29.
  disruption phenotype: Viable, with no defects in coordination (PubMed:30407909). Decreased number of synaptic nicotinic acetylcholine receptors (nAChRs) at neuromuscular junctions (PubMed:30407909). Isoform a: Deletion leads to reduced sensitivity to the nAChR agonist levamisole (PubMed:30407909). Isoform b: Deletion leads to sensitivity to levamisole as in wild-type (PubMed:30407909).

CREL1_MOUSE / Q91XD7 Protein disulfide isomerase Creld1; Cysteine-rich with EGF-like domain protein 1; EC 5.3.4.1 from Mus musculus (Mouse) (see paper)
Aligns to 45:103 / 420 (14.0%), covers 41.3% of PF11938, 49.1 bits

• function: Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (PubMed:30407909).
  catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins.

CREL1_HUMAN / Q96HD1 Protein disulfide isomerase CRELD1; Cysteine-rich with EGF-like domain protein 1; EC 5.3.4.1 from Homo sapiens (Human) (see 5 papers)
2 alignments in 45:142 / 420 (23.3%), covering up to 41.3% of PF11938, 46.0 bits

• function: Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity).
  catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins.

CREL1_XENTR / A0A6I8RMG7 Protein disulfide isomerase CRELD1; Cysteine-rich with EGF-like domain protein 1; EC 5.3.4.1 from Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) (see paper)
Aligns to 86:128 / 410 (10.5%), covers 26.0% of PF11938, 38.5 bits

• function: Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity).
  catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins.
  disruption phenotype: About half of the knockdown tadpoles exhibit severe defects of either early gastrulation disruption or edema and late embryonic lethality. Some also have tail defects. Surviving tadpoles show more robust seizure behaviors than wild-type in response to pilocarpine treatment.

MZB1_MOUSE / Q9D8I1 Marginal zone B- and B1-cell-specific protein; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; pERp1; Proapoptotic caspase adapter protein from Mus musculus (Mouse) (see 4 papers)
Aligns to 48:177 / 188 (69.1%), covers 99.3% of PF11938, 35.2 bits

• function: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation
  function: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance
  subunit: Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.

MZB1_HUMAN / Q8WU39 Marginal zone B- and B1-cell-specific protein; Mesenteric estrogen-dependent adipose 7; MEDA-7; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; pERp1; Proapoptotic caspase adapter protein from Homo sapiens (Human) (see 4 papers)
Aligns to 49:178 / 189 (68.8%), covers 100.0% of PF11938, 28.4 bits

• function: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B- cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.
  function: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance
  subunit: Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains (By similarity). Isoform 2 interacts with CASP2 and CASP9. Interacts with HSP90B1 and PDIA3 in a calcium- dependent manner (By similarity).

Or search for genetic data about PF11938 in the Fitness Browser