Family Search for PF12018 (FAP206)

PF12018 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

CF206_MOUSE / Q6PE87 Cilia- and flagella-associated protein 206 from Mus musculus (Mouse) (see paper)
Aligns to 214:491 / 622 (44.7%), covers 100.0% of PF12018, 377.3 bits

• function: [Isoform 1]: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (PubMed:32376681). Required for the establishment of radial spokes in sperm flagella (PubMed:32376681).
  function: [Isoform 2]: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (PubMed:32376681). Required for the establishment of radial spokes in sperm flagella (PubMed:32376681).
  disruption phenotype: Mice postnatally develop hydrocephalus, show impaired mucociliary clearance of the airways and are characterized by male infertility.

CF206_TETTS / Q23H79 Cilia- and flagella-associated protein 206; Flagella-associated protein 206 from Tetrahymena thermophila (strain SB210) (see paper)
Aligns to 226:497 / 635 (42.8%), covers 99.6% of PF12018, 269.5 bits

• function: May regulate cilium motility through its role in the assembly of the axonemal RS2 radial spoke.
  disruption phenotype: The mobility of cells lacking CFAP206 is decreased. If their number is normal, cilia are slightly longer and display uncoordinated motility with abnormal waveform characterized by decreased bend amplitude and decreased metachronal coordination. Cilia axonemes display a classical 9+2 organization of microtubules but their shape is abnormal.

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