Family Search for PF12478 (UBAP2-Lig)

PF12478 hits 15 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

LIG_DROME / Q86S05 Protein lingerer from Drosophila melanogaster (Fruit fly) (see 3 papers)
Aligns to 575:610 / 1375 (2.6%), covers 100.0% of PF12478, 71.3 bits

• function: Acts in the nervous system to mediate the control of copulatory organs during courtship.
  disruption phenotype: Male flies exhibit abnormal copulation. They fail to successfully withdraw their genitalia upon termination of copulation so end up 'stuck' to the female, tugging to separate. There is also a 'non-copulating' behavioral phenotype. There are no morphological defects in the male genitalia. Females can mate successfully but have reduced fertility. Complete loss of lig function results in lethality during early pupal stages.

LIG_AEDAE / Q16VD3 Protein lingerer from Aedes aegypti (Yellowfever mosquito) (Culex aegypti) (see paper)
Aligns to 538:572 / 1250 (2.8%), covers 100.0% of PF12478, 71.3 bits

• function: Acts in the nervous system to mediate the control of copulatory organs during courtship.

UBAP2_HUMAN / Q5T6F2 Ubiquitin-associated protein 2; UBAP-2; RNA polymerase II degradation factor UBAP2 from Homo sapiens (Human) (see 2 papers)
Aligns to 512:544 / 1119 (2.9%), covers 100.0% of PF12478, 64.0 bits

• function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050).
  subunit: May interact with ANXA2.

UBP2L_MOUSE / Q80X50 Ubiquitin-associated protein 2-like; RNA polymerase II degradation factor Ubap2l from Mus musculus (Mouse) (see 2 papers)
Aligns to 515:546 / 1107 (2.9%), covers 97.0% of PF12478, 58.8 bits

• function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (By similarity). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT- HSCs) (PubMed:25185265). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:35977029). Required for proper brain development and neocortex lamination (PubMed:35977029).
  subunit: Interacts with BMI1. Part of a complex consisting of UBAP2L, BMI1 and RNF2. Interacts with G3BP1 (via NTF2 domain); promoting stress granule formation.
  disruption phenotype: Ubap2l knockout results in a lethal phenotype in a majority of embryos. Mice with heterozygous Ubap2l deletion have cognitive impairment and behavioral abnormalities, including lower preference for social novelty, mild repetitive behavior, anxious-like behavior, and abnormal spatial working memory compared to wild-type mice. Stress granule intensity and numbers are reduced in developing brains of Ubap2l-deficient mice compared to controls, and neocortex development and lamination is abnormal.

UBP2L_HUMAN / Q14157 Ubiquitin-associated protein 2-like; Protein NICE-4; RNA polymerase II degradation factor UBAP2L from Homo sapiens (Human) (see 6 papers)
Aligns to 495:526 / 1087 (2.9%), covers 97.0% of PF12478, 58.7 bits

• function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT- HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity).
  subunit: Interacts with BMI1 (PubMed:25185265). Part of a complex consisting of UBAP2L, BMI1 and RNF2 (PubMed:25185265). Interacts with G3BP1 (via NTF2 domain); promoting stress granule formation (PubMed:32302570).

Or search for genetic data about PF12478 in the Fitness Browser