Family Search for PF12530 (DUF3730)

PF12530 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

RST1_ARATH / Q7XZF5 Protein RST1; Protein RESURRECTION 1 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
2 alignments in 82:750 / 1841 (27.3%), covering up to 99.1% of PF12530, 393.7 bits

• function: Involved in cuticular wax formation (PubMed:16183838, PubMed:19625635). Required for the synthesis of alkanes from wax precursors (PubMed:16183838, PubMed:19625635). May play a role in acyl- CoA reduction to aldehydes (PubMed:16183838). Is repressed by FREE1 and functions downstream of FREE1 to negatively regulate multivesicular body (MVB) biogenesis and vacuolar transport (PubMed:31221737). Together with CER16/RIPR, acts as a cofactor of the cytoplasmic exosome and connects the cytosolic RNA exosome to the SKI complex (PubMed:31455787). Acts as a post-transcriptional gene silencing (PTGS) suppressor (PubMed:31076735, PubMed:31455787). RST1 can, like CER16/RIPR, suppress the production of small interfering RNAs (siRNAs) from the CER3 locus, which is involved in cuticule membrane and wax production, and in the typhine and sporopollenin biosynthesis of pollen (PubMed:31455787).
  subunit: Interacts with CER16/RIPR.
  disruption phenotype: Shrunken non viable seeds due to arrested embryo development when homozygous (PubMed:16183838). Alteration in cuticular waxes with elevated amounts of cutin monomers in leaves (PubMed:16183838, PubMed:19625635). Susceptibility to the obligate biotrophic fungus E.cichoracearum and increased resistance to the necrotrophic fungi B.cinerea and A.brassicicola (PubMed:19625635).

FOCAD_HUMAN / Q5VW36 Focadhesin from Homo sapiens (Human) (see 3 papers)
Aligns to 490:714 / 1801 (12.5%), covers 100.0% of PF12530, 260.8 bits

• function: Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex (PubMed:35864190). Potential tumor suppressor in gliomas.
  subunit: Interacts with VCL.

FOCAD_MOUSE / A2AKG8 Focadhesin from Mus musculus (Mouse) (see paper)
Aligns to 490:714 / 1798 (12.5%), covers 100.0% of PF12530, 259.2 bits

• function: Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex (By similarity). Potential tumor suppressor in gliomas.
  subunit: Interacts with VCL.

FOCAD_DANRE / E7FGT5 Focadhesin from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 492:716 / 1806 (12.5%), covers 100.0% of PF12530, 249.0 bits

• function: Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex.
  disruption phenotype: Gene knockdown results in decreased overall survival and growth retardation. Mutant fishes have pathological liver features, including swollen hepatocytes, steatosis, fibrosis, and hepatocyte apoptosis.

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