Family Search for PF13349 (DUF4097)

PF13349 hits 52 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

LIAG_BACSU / O32200 Protein LiaG from Bacillus subtilis (strain 168) (see 6 papers)
Aligns to 48:290 / 290 (83.8%), covers 100.0% of PF13349, 229.8 bits

• disruption phenotype: Up-regulates expression of liaI which in turn induces the liaRS two-component regulatory system.

LIAX_ENTFA / Q834B6 Putative adhesin domain-containing protein LiaX; Daptomycin-sensing surface protein LiaX from Enterococcus faecalis (strain ATCC 700802 / V583) (see paper)
Aligns to 277:529 / 533 (47.5%), covers 97.6% of PF13349, 66.5 bits

• function: Involved in cell membrane remodeling, perhaps acting by negative modulation of the liaFSR and liaXYZ gene clusters, thereby regulating content and localization of anionic phospholipids (PubMed:31818937). Binds to the antibiotic daptomycin (DAP) and to cationic antimicrobial peptides, such as human LL-37, perhaps functioning as a sensor that activates the cell envelope stress response (PubMed:31818937).
  disruption phenotype: Deletion in the OG1RF strain causes anionic phospholipids to be redistributed away from the division septum; during exponential growth, there are increases in phosphatidylglycerol (PG), decreases in cardiolipin, with no change in lysyl-PG (PubMed:31818937). Confers resistance to the antibiotic daptomycin (DAP) in the OG1RF strain (PubMed:31818937). Resistant to killing of the OG1RF strain by human cathelicidin LL-37 (PubMed:31818937). Deletion in the OG1RF strain increases virulence in nematode C.elegans infection model (PubMed:31818937).

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