Family Search for PF13427 (AadA_C)

PF13427 hits 47 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

S9AD_STAAU / P0A0D2 Spectinomycin 9-adenylyltransferase; AAD(9) from Staphylococcus aureus (see paper)
Aligns to 152:254 / 260 (39.6%), covers 98.1% of PF13427, 119.4 bits

• function: Mediates bacterial resistance to the antibiotic spectinomycin but not streptomycin.
  catalytic activity: ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate (RHEA:63228)

S3AD_ECOLX / P0AG05 Aminoglycoside (3'') (9) adenylyltransferase; Aminoglycoside 3''-adenylyltransferase; AAD(3'') (9) adenylyltransferase; Streptomycin 3''-adenylyltransferase; EC 2.7.7.47 from Escherichia coli (see 2 papers)
Q71UU1 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Enterococcus faecalis (see paper)
Aligns to 152:256 / 263 (39.9%), covers 98.1% of PF13427, 112.6 bits

• function: Mediates bacterial resistance to the antibiotics streptomycin and spectinomycin.
  catalytic activity: ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate (RHEA:20245)
  catalytic activity: ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate (RHEA:63228)
  disruption phenotype: Loss of resistance to streptomycin and spectinomycin.

Q79JG0 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Escherichia coli (see paper)
Aligns to 152:256 / 263 (39.9%), covers 98.1% of PF13427, 112.5 bits

Q5DUC3 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Escherichia coli (see paper)
Aligns to 148:252 / 259 (40.5%), covers 98.1% of PF13427, 112.4 bits

S3AD_SHIFL / P0AG06 Aminoglycoside (3'') (9) adenylyltransferase; Streptomycin 3''-adenylyltransferase; EC 2.7.7.47 from Shigella flexneri (see paper)
Aligns to 152:255 / 262 (39.7%), covers 98.1% of PF13427, 108.7 bits

• function: Mediates bacterial resistance to the antibiotics streptomycin and spectinomycin.
  catalytic activity: ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate (RHEA:20245)
  catalytic activity: ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate (RHEA:63228)

P08881 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Klebsiella pneumoniae (see paper)
Aligns to 152:255 / 262 (39.7%), covers 98.1% of PF13427, 108.7 bits

Q51348 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Escherichia coli (see paper)
Aligns to 148:252 / 259 (40.5%), covers 97.1% of PF13427, 106.8 bits

Q9F7C0 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Escherichia coli (see paper)
Aligns to 152:256 / 263 (39.9%), covers 97.1% of PF13427, 106.7 bits

S3AD_RHIRD / P14511 Aminoglycoside (3'') (9) adenylyltransferase; Streptomycin 3''-adenylyltransferase; SP-R; EC 2.7.7.47 from Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter) (see 2 papers)
Aligns to 158:262 / 269 (39.0%), covers 97.1% of PF13427, 106.7 bits

• function: Mediates bacterial resistance to the antibiotic spectinomycin and probably also to streptomycin.
  catalytic activity: ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate (RHEA:20245)
  catalytic activity: ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate (RHEA:63228)
  disruption phenotype: Loss of resistance to spectinomycin.

Q5UNL3 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Escherichia coli (see paper)
Aligns to 152:256 / 263 (39.9%), covers 98.1% of PF13427, 105.7 bits

Q9R3A9 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Escherichia coli (see paper)
Aligns to 152:256 / 262 (40.1%), covers 98.1% of PF13427, 104.9 bits

Q59694 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Pseudomonas aeruginosa (see paper)
Aligns to 148:252 / 259 (40.5%), covers 97.1% of PF13427, 103.9 bits

Q9L799 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Escherichia coli (see paper)
Aligns to 152:256 / 265 (39.6%), covers 97.1% of PF13427, 99.9 bits

S3AD_SALTY / Q8ZPX9 Aminoglycoside (3'') (9) adenylyltransferase; AadA; Aminoglycoside nucleotidyltransferase (3'') (9) adenyltransferase; ANT(3'') (9) adenyltransferase; EC 2.7.7.47 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
Q8ZPX9 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
Aligns to 152:256 / 262 (40.1%), covers 98.1% of PF13427, 98.9 bits

• function: Mediates bacterial resistance to the antibiotics streptomycin and spectinomycin, does not confer resistance to kanamycin (PubMed:26527143). Binds ATP first, then antibiotic (PubMed:26527143, PubMed:29871922).
  catalytic activity: ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate (RHEA:20245)
  catalytic activity: ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate (RHEA:63228)
  subunit: Monomer.
  disruption phenotype: Loss of streptomycin and spectinomycin resistance.

Q9RGC2 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Pseudomonas aeruginosa (see paper)
Aligns to 152:256 / 281 (37.4%), covers 98.1% of PF13427, 98.1 bits

Q8VQN7 aminoglycoside 6'-N-acetyltransferase (EC 2.3.1.82) from Serratia marcescens (see paper)
Aligns to 152:256 / 463 (22.7%), covers 97.1% of PF13427, 96.2 bits

S9AD_CAMJU / Q4VR99 Spectinomycin 9-adenylyltransferase; ORF8 from Campylobacter jejuni (see paper)
Aligns to 148:250 / 258 (39.9%), covers 100.0% of PF13427, 94.1 bits

• function: Mediates bacterial resistance to spectinomycin, is probably a spectinomycin 9-adenylyltransferase.
  catalytic activity: ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate (RHEA:63228)
  disruption phenotype: Loss of spectinomycin resistance.

Y9645_CAMJU / Q4VR96 Probable nucleotidyltransferase; ORF11; EC 2.7.7.- from Campylobacter jejuni (see paper)
Aligns to 152:251 / 264 (37.9%), covers 97.1% of PF13427, 80.5 bits

• function: Probably a nucleotidyltransferase, it does not confer spectinomycin or streptomyin resistance in situ or in E.coli.
  disruption phenotype: No change in spectinomycin or streptomycin resistance.

N8W714 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Acinetobacter sp. NIPH 758 (IIb) (see paper)
Aligns to 144:249 / 263 (40.3%), covers 96.1% of PF13427, 71.7 bits

S9AD_ENTFL / Q07448 Spectinomycin 9-adenylyltransferase; AAD(9) from Enterococcus faecalis (Streptococcus faecalis) (see paper)
Aligns to 152:251 / 255 (39.2%), covers 97.1% of PF13427, 71.2 bits

• function: Mediates bacterial resistance to the antibiotic spectinomycin but not streptomycin.
  catalytic activity: ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate (RHEA:63228)

D0CEM6 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Acinetobacter baumannii (see paper)
Aligns to 146:249 / 262 (39.7%), covers 95.1% of PF13427, 69.9 bits

Q2FD58 streptomycin 3''-adenylyltransferase (EC 2.7.7.47) from Acinetobacter baumannii (see paper)
Aligns to 146:249 / 262 (39.7%), covers 95.1% of PF13427, 67.0 bits

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