Family Search for PF13886 (DUF4203)

PF13886 hits 8 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TM198_XENTR / Q6DFQ7 Transmembrane protein 198 from Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) (see paper)
Aligns to 36:232 / 342 (57.6%), covers 100.0% of PF13886, 167.5 bits

• function: Promotes lrp6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of lrp6 further enhancing its activity. Required for neural crest formation.
  subunit: Interacts with lrp6. Interacts with casein kinases.
  disruption phenotype: Morphants have defects in neural crest formation. At the tadpole stage, animals are often less pigmented with ventrally bent tails. Embryos develop smaller eyes and forebrain structures.

TM198_HUMAN / Q66K66 Transmembrane protein 198 from Homo sapiens (Human) (see paper)
Aligns to 40:236 / 360 (54.7%), covers 99.5% of PF13886, 157.3 bits

• function: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.
  subunit: Interacts with LRP6.

TM7S3_HUMAN / Q9NS93 Transmembrane 7 superfamily member 3; Seven span transmembrane protein from Homo sapiens (Human) (see 3 papers)
Aligns to 296:503 / 570 (36.5%), covers 100.0% of PF13886, 144.7 bits

• function: Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).

TM7S3_MOUSE / Q9CRG1 Transmembrane 7 superfamily member 3; NARP1 from Mus musculus (Mouse) (see 2 papers)
Aligns to 291:498 / 565 (36.8%), covers 100.0% of PF13886, 135.9 bits

• function: Involved in the inhibition of cytokine-induced death of pancreatic beta cells (PubMed:21853325). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).

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