Family Search for PF13962 (PGG)

PF13962 hits 43 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

ITN1_ARATH / Q9C7A2 Ankyrin repeat-containing protein ITN1; Protein INCREASED TOLERANCE TO NACL from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 412:519 / 590 (18.3%), covers 99.1% of PF13962, 98.9 bits

• function: Involved in salt stress tolerance. May act through abscisic acid (ABA) signaling pathways and promote reactive oxygen species (ROS) production.
  subunit: Interacts with REM19/RTV1.
  disruption phenotype: No visible phenotype under normal growth conditions, but mutant seedlings show increased salt-stress tolerance.

ACD6_ARATH / Q8LPS2 Protein ACCELERATED CELL DEATH 6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
Aligns to 484:597 / 670 (17.0%), covers 96.6% of PF13962, 94.9 bits

• function: Dose-dependent activator of the defense response against virulent pathogens, including bacteria, fungi and oomycetes, that acts in a positive feedback loop with the defense signal salicylic acid (SA) (PubMed:10488236, PubMed:14507999, PubMed:16297071, PubMed:19144005, PubMed:20520716). Regulates the salicylic acid (SA) signaling pathway leading to cell death and modulating cell fate (e.g. cell enlargement and/or cell division) (PubMed:10488236, PubMed:11722764, PubMed:14507999). In response to SA signaling, triggers the accumulation of FLS2 at the plasma membrane, thus priming defenses (PubMed:24923602). Involved in SA-dependent freezing signaling and tolerance (PubMed:19959255).
  subunit: Component of large complexes containing, at least, FLS2, HSP70 and ACD6 in endoplasmic reticulum, plasma membrane and soluble fraction. Associated with HSP70 proteins during endoplasmic reticulum- associated degradation (ERAD). Reduced complex levels upon benzothiazole (BTH) treatment.
  disruption phenotype: Reduced responsiveness to benzothiazole (BTH) and upon P. syringae infection with reduced salicylic acid (SA) levels and increased disease susceptibility and attenuated defenses (PubMed:14507999). Increased sensitivity to biotrophic fungi (e.g. Golovinomyces orontii T1 and G. cichoracearum UCSC1), biotrophic oomycetes (e.g. Hyaloperonospora arabidopsidis Noco2) and hemi- biotrophic bacteria (e.g. Pseudomonas syringae pv. tomato DC3000) (PubMed:20520716).

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