Family Search for PF14309 (DUF4378)

PF14309 hits 32 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

LNG1_ARATH / Q9LF24 Protein LONGIFOLIA 1; Protein TON1 RECRUITING MOTIF 2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 721:904 / 927 (19.8%), covers 100.0% of PF14309, 132.5 bits

• function: In association with LNG2, regulates leaf morphology by promoting longitudinal polar cell elongation independently of ROT3.
  subunit: Interacts (via C-terminus) with TON1A and TON1B.
  disruption phenotype: No visible phenotype under normal growth conditions, but the lng1 and lng2 double mutant shows reduced length of cotyledons, rosette leaves, siliques and flowers.

LNG2_ARATH / Q9S823 Protein LONGIFOLIA 2; Protein TON1 RECRUITING MOTIF 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 721:901 / 905 (20.0%), covers 99.4% of PF14309, 117.8 bits

• function: In association with LNG1, regulates leaf morphology by promoting longitudinal polar cell elongation independently of ROT3. Associates with microtubules and recruits TON1A and TON1B to the cytoskeleton through its C-terminus.
  subunit: Interacts (via C-terminus) with TON1A and TON1B.
  disruption phenotype: No visible phenotype under normal growth conditions, but the lng1 and lng2 double mutant shows reduced length of cotyledons, rosette leaves, siliques and flowers.

CE350_MOUSE / E9Q309 Centrosome-associated protein 350; Cep350 from Mus musculus (Mouse) (see paper)
Aligns to 2916:3077 / 3095 (5.2%), covers 67.5% of PF14309, 28.5 bits

• function: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation.
  subunit: Part of a ternary complex that contains CEP350, CEP43 and MAPRE1. Interacts (via C-terminus) directly with CEP43 (via N- terminus). Interacts with NR1H3, PPARA, PPARD and PPARG. Interacts directly with microtubules. Interacts with the fusion protein CEP43- FGFR1, and by doing so recruits and activates PI3K and PLC-gamma. Interacts with CYLD (By similarity). Interacts with CFAP157 (PubMed:27965440). Interacts with CEP19 (via C-terminus) (By similarity).

CE350_HUMAN / Q5VT06 Centrosome-associated protein 350; Cep350; Centrosome-associated protein of 350 kDa from Homo sapiens (Human) (see 11 papers)
Aligns to 2922:3099 / 3117 (5.7%), covers 68.7% of PF14309, 27.6 bits

• function: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385).
  subunit: Part of a ternary complex that contains CEP350, CEP43 and MAPRE1. Interacts (via C-terminus) directly with CEP43 (via N-terminus) (PubMed:16314388, PubMed:28428259, PubMed:28625565). Interacts with NR1H3, PPARA, PPARD and PPARG (PubMed:15615782). Interacts directly with microtubules (PubMed:17878239). Interacts with the fusion protein CEP43-FGFR1, and by doing so recruits and activates PI3K and PLC-gamma (PubMed:18412956). Interacts with CYLD (PubMed:25134987). Interacts with CFAP157 (By similarity). Interacts with CEP19 (via C-terminus) (PubMed:28659385).

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