Family Search for PF14988 (DUF4515)

PF14988 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

BBOF1_MOUSE / Q3V079 Basal body-orientation factor 1; Coiled-coil domain-containing protein 176 from Mus musculus (Mouse) (see paper)
Aligns to 83:276 / 533 (36.4%), covers 100.0% of PF14988, 161.0 bits

• function: Plays an essential role in sperm motility and male fertility by stabilizing the sperm flagellar axonemal structure. May be required for the stability of ODF2 and MANS1 proteins. Dispensable for the assembly and function of motile cilia.
  subunit: Interacts with MNS1 and ODF2.
  disruption phenotype: Mice show reduced sperm motility and male subfertility without obvious sperm morphological defects. Abnormalities in sperm flagellar axoneme seen, with an absence of one to three microtubule doublets in the principal piece and end piece of the sperm flagellum. Motile cilia are normally distributed on the epithelial cells of the trachea and the axonemal structure of cilia is intact.

BBOF1_XENLA / A0JMY4 Basal body-orientation factor 1; Coiled-coil domain-containing protein 176 from Xenopus laevis (African clawed frog) (see paper)
Aligns to 80:273 / 531 (36.5%), covers 98.1% of PF14988, 82.7 bits

• function: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
  disruption phenotype: Cilia in multiciliate cells are motile but fail to produce flow. Multiciliated cells are present in the normal number, cilia of normal length and of normal density. They are however misoriented.

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