Family Search for PF14990 (DUF4516)

PF14990 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

UQCC6_MOUSE / Q8BTC1 Ubiquinol-cytochrome c reductase complex assembly factor 6; Protein BRAWNIN from Mus musculus (Mouse) (see 2 papers)
Aligns to 1:46 / 67 (68.7%), covers 100.0% of PF14990, 89.9 bits

• function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III or cytochrome b- c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263, PubMed:35977508). Mediates early complex III biogenesis (PubMed:35977508). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (PubMed:35977508). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity).
  subunit: Interacts with UQCRC1 (PubMed:32161263). Interacts with UQCRQ (PubMed:32161263). Interacts with UQCC5 (By similarity). Forms a complex, named COMB/coordinator of mitochondrial CYTB biogenesis, composed of UQCC1, UQCC2, UQCC4, UQCC5 and UQCC6; stabilizes nascent cytochrome b/MT-CYB and promotes its membrane insertion (PubMed:35977508). Forms a complex, named COMA, composed of UQCC1, UQCC2 and UQCC4; activates MT-CYB translation (PubMed:35977508). Forms a complex, named COMC, composed of UQCC1, UQCC2; UQCC3 and UQCC4; mediates MT-CYB hemylation and association with the first nuclear- encoded complex III subunit UQCRQ (PubMed:35977508). Interacts with MT- CYB (PubMed:35977508).
  disruption phenotype: Uqcc6 deficiency leads to complete loss of mitochondrial respiratory chain complex III, resulting in growth retardation and a mild increase in blood lactate levels and significantly decreased exercise tolerance. The subunits of mitochondrial respiratory chain complex I, II, IV, and V are not affected.

UQCC6_DANRE / E7EXZ6 Ubiquinol-cytochrome-c reductase complex assembly factor 6; Protein brawnin from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 1:46 / 65 (70.8%), covers 100.0% of PF14990, 89.4 bits

• function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263). Mediates early complex III biogenesis. Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity).
  disruption phenotype: A complete loss of mitochondrial respiratory chain complex III resulting in severe growth retardation, lactic acidosis and early death.

UQCC6_DROME / B7Z0X7 Ubiquinol-cytochrome c reductase complex assembly factor 6; UQCC6 from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 1:46 / 61 (75.4%), covers 100.0% of PF14990, 87.7 bits

• function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation.
  subunit: Interacts with sloth1; the interaction stabilizes both components.
  disruption phenotype: Adult lethal, mainly due to flies becoming stuck in the food medium post eclosion (PubMed:36346220). Rare escaper adult flies have slow motor activity, reduced climbing ability and short scutellar bristles (PubMed:36346220). Larval motor neurons and adult photoreceptors have a reduced ability to maintain a synaptic response upon repeated stimulation (PubMed:36346220). Impaired mitochondrial function in larvae (PubMed:36346220).

UQCC6_HUMAN / Q69YU5 Ubiquinol-cytochrome c reductase complex assembly factor 6; Protein BRAWNIN from Homo sapiens (Human) (see 2 papers)
Aligns to 1:46 / 71 (64.8%), covers 97.8% of PF14990, 79.3 bits

• function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263). Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly (PubMed:34969438).
  subunit: Interacts with UQCRC1 (PubMed:32161263). Interacts with UQCRQ (By similarity). Interacts with UQCC5 (PubMed:34969438). Forms a complex, named COMB/coordinator of mitochondrial CYTB biogenesis, composed of UQCC1, UQCC2, UQCC4, UQCC5 and UQCC6; stabilizes nascent cytochrome b/MT-CYB and promotes its membrane insertion. Forms a complex, named COMA, composed of UQCC1, UQCC2 and UQCC4; activates MT- CYB translation. Forms a complex, named COMC, composed of UQCC1, UQCC2; UQCC3 and UQCC4; mediates MT-CYB hemylation and association with the first nuclear-encoded complex III subunit UQCRQ (By similarity). Interacts with MT-CYB (By similarity).

Or search for genetic data about PF14990 in the Fitness Browser