Family Search for PF15091 (DUF4554)

PF15091 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TO6BL_HUMAN / Q8N6T0 Type 2 DNA topoisomerase 6 subunit B-like; TOP6B like initiator of meiotic double strand breaks; Type 2 DNA topoisomerase VI subunit B-like; TOPOVIBL from Homo sapiens (Human) (see 2 papers)
Aligns to 54:505 / 511 (88.5%), covers 100.0% of PF15091, 929.4 bits

• function: [Isoform 3]: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
  subunit: [Isoform 3]: Heterotetramer of SPO11 and 2 TOP6BL chains. Interacts with SPO11.

TO6BL_MOUSE / J3QMY9 Type 2 DNA topoisomerase 6 subunit B-like; TOP6B like initiator of meiotic double strand breaks; Type 2 DNA topoisomerase VI subunit B-like; TOPOVIBL from Mus musculus (Mouse) (see paper)
Aligns to 120:573 / 579 (78.4%), covers 100.0% of PF15091, 818.7 bits

• function: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
  subunit: Heterotetramer of SPO11 and 2 TOP6BL chains (Probable). Interacts with SPO11 (PubMed:26917764).
  disruption phenotype: Male mice develop normally and reach adulthood but have smaller testes. Spermatogonia are present at the periphery of tubules but are strongly depleted and spermatids are absent, due to defects during meiotic prophase.

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