Family Search for PF15167 (DUF4581)

PF15167 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

MTURN_DANRE / P0C8M4 Maturin; Maturin neural progenitor differentiation regulator protein homolog from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 4:133 / 133 (97.7%), covers 100.0% of PF15167, 285.2 bits

• function: May be involved in early neuronal development (By similarity). May play a role in promoting megakaryocyte differentiation (By similarity).

MTURN_XENLA / Q7ZX36 Maturin; Maturin neural progenitor differentiation regulator protein from Xenopus laevis (African clawed frog) (see paper)
Aligns to 4:131 / 131 (97.7%), covers 100.0% of PF15167, 278.9 bits

• function: Involved in early neuronal development; required for cell cycle exit and differentiation of primary neurons (By similarity). Cooperates synergistically with pak3 to promote primary neural differentiation within the neural plate (PubMed:24095902). May play a role in promoting megakaryocyte differentiation (By similarity).
  disruption phenotype: Morpholino knockdown of the protein causes an accumulation of neuronal progenitor cells resulting in the neural plate expansion.

MTURN_HUMAN / Q8N3F0 Maturin; Maturin neural progenitor differentiation regulator protein homolog; Protein Ells1 from Homo sapiens (Human) (see paper)
Aligns to 4:131 / 131 (97.7%), covers 100.0% of PF15167, 267.0 bits

• function: Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536' (PubMed:24681962). May be involved in early neuronal development (By similarity).

MTURN_MOUSE / Q8CGA4 Maturin; Maturin neural progenitor differentiation regulator protein homolog from Mus musculus (Mouse) (see 2 papers)
Aligns to 4:131 / 131 (97.7%), covers 100.0% of PF15167, 263.7 bits

• function: Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May be involved in early neuronal development (By similarity).

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