Family Search for PF15262 (DUF4592)

PF15262 hits 12 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

CRACD_MOUSE / Q5PR69 Capping protein-inhibiting regulator of actin dynamics; Cancer-related regulator of actin dynamics from Mus musculus (Mouse) (see paper)
Aligns to 45:173 / 1291 (10.0%), covers 100.0% of PF15262, 146.8 bits

• function: Involved in epithelial cell integrity by acting on the dynamics of the actin cytoskeleton (PubMed:30361697). Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin (By similarity).
  subunit: Directly interacts with actin-capping proteins CAPZA1, CAPZA2 and CAPZB; this interaction decreases the binding of capping proteins to actin.
  disruption phenotype: Knockout mice display adenoma development in the small intestine in an age-dependent manner. They also develop pulmonary lesions resembling early small cell lung cancer and solid- pseudopapillary neoplasm of the pancreas. Tumors from mutant animals show increased expression of Wnt/beta-catenin target genes without the alteration of other signaling pathways. Intestinal tumors exhibit disorganized and decreased levels of F-actin.

CRACD_HUMAN / Q6ZU35 Capping protein-inhibiting regulator of actin dynamics; Cancer-related regulator of actin dynamics from Homo sapiens (Human) (see paper)
Aligns to 45:173 / 1233 (10.5%), covers 100.0% of PF15262, 145.6 bits

• function: Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin.
  subunit: Directly interacts with actin-capping proteins CAPZA1, CAPZA2 and CAPZB; this interaction decreases the binding of capping proteins to actin.

K1210_MOUSE / E9Q0C6 Acrosomal protein KIAA1210 from Mus musculus (Mouse) (see paper)
Aligns to 119:211 / 1637 (5.7%), covers 49.2% of PF15262, 41.7 bits

• subunit: Interacts with TOP2B.

Or search for genetic data about PF15262 in the Fitness Browser