Family Search for PF15395 (DUF4617)

PF15395 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

RESF1_MOUSE / Q5DTW7 Retroelement silencing factor 1 from Mus musculus (Mouse) (see paper)
Aligns to 451:1511 / 1521 (69.8%), covers 100.0% of PF15395, 1433.7 bits

• function: Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.
  subunit: Interacts with SETDB1.

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