Family Search for PF16401 (DUF5009)

PF16401 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

Sama_0947 transmembrane glucosamine N-acetyltransferase NagX from Shewanella amazonensis SB2B
Aligns to 12:185 / 378 (46.0%), covers 61.2% of PF16401, 32.7 bits

• mutant phenotype: Specifically important for glucosamine utilization. NagX proteins are distantly related to human HGSNAT (uniprot:Q68CP4), which is a transmembrane acetyl-CoA:alpha-glucosaminide N-acetyltransferase.

Echvi_1106 transmembrane glucosamine N-acetyltransferase NagX from Echinicola vietnamensis KMM 6221, DSM 17526
Aligns to 5:106 / 369 (27.6%), covers 38.1% of PF16401, 31.3 bits

• mutant phenotype: Specifically important for glucosamine utilization. NagX proteins are distantly related to human HGSNAT (uniprot:Q68CP4), which is a transmembrane acetyl-CoA:alpha-glucosaminide N-acetyltransferase.

Shewana3_3111 transmembrane glucosamine N-acetyltransferase NagX from Shewanella sp. ANA-3
nagX / A0KZW6 D-glucosamine N-acetyltransferase (EC 2.3.1.3) from Shewanella sp. (strain ANA-3) (see paper)
Aligns to 29:209 / 395 (45.8%), covers 64.6% of PF16401, 30.4 bits

• mutant phenotype: Specifically important for glucosamine utilization. NagX proteins are distantly related to human HGSNAT (uniprot:Q68CP4), which is a transmembrane acetyl-CoA:alpha-glucosaminide N-acetyltransferase.

HGNAT_MOUSE / Q3UDW8 Heparan-alpha-glucosaminide N-acetyltransferase; Transmembrane protein 76; EC 2.3.1.78 from Mus musculus (Mouse) (see 2 papers)
Q3UDW8 heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) from Mus musculus (see paper)
Aligns to 286:389 / 656 (15.9%), covers 21.9% of PF16401, 27.4 bits

• function: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.
  catalytic activity: acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) (RHEA:15125)
  subunit: Homooligomer. Homooligomerization is necessary for enzyme activity (By similarity).

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