Family Search for PF17825 (DUF5587)

PF17825 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

SHOC1_HUMAN / Q5VXU9 Protein shortage in chiasmata 1 ortholog; Protein ZIP2 homolog; MZIP2; EC 3.6.-.- from Homo sapiens (Human) (see 4 papers)
Aligns to 1:1444 / 1444 (100.0%), covers 100.0% of PF17825, 2968.6 bits

• function: ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (By similarity). Required for proper synaptonemal complex assembly and homologous chromosome pairing (By similarity). Requiref for recruitment TEX11 and MSH4 to recombination intermediates (By similarity).
  subunit: Interacts with TEX11 (PubMed:29742103). Interacts with SPO16 (By similarity).

SHOC1_MOUSE / A2ALV5 Protein shortage in chiasmata 1 ortholog; Protein ZIP2 homolog; MZip2; EC 3.6.-.- from Mus musculus (Mouse) (see 4 papers)
Aligns to 66:1481 / 1481 (95.6%), covers 100.0% of PF17825, 2712.8 bits

• function: ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (PubMed:30272023). Required for proper synaptonemal complex assembly and homologous chromosome pairing (PubMed:35485979). Required for recruitment of TEX11 and MSH4 to recombination intermediates (PubMed:30272023).
  subunit: Interacts with TEX11 (By similarity). Interacts with SPO16 (PubMed:30746471).
  disruption phenotype: Mice show severe defects in meiotic prophase I, such as DNA double-strand break (DSB) repair, crossover formation and synapsis in spermatocytes and oocytes resulting in sterility in both male and females (PubMed:30272023). Embryonic lethality due to defects in meiosis (PubMed:29742103). The use of a hypomorphic allele showed that spermatogenesis progresses normally until the end of prophase I when spermatocytes arrest at metaphase I: homologous chromosomes pair in spermatocytes but show defective synapsis (PubMed:29742103).

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