Family Search for PF02153 (PDH_N)

PF02153 hits 104 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TYRC_ZYMMO / Q04983 Cyclohexadienyl dehydrogenase; Arogenate dehydrogenase; ADH; Prephenate dehydrogenase; PDH; EC 1.3.1.43; EC 1.3.1.12 from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see paper)
Aligns to 19:173 / 293 (52.9%), covers 98.7% of PF02153, 189.7 bits

• function: Can function as either prephenate dehydrogenase or as arogenate dehydrogenase in the biosynthesis of L-tyrosine. Catalyzes two analogous reactions: converts prephenate to 4-hydroxyphenylpyruvate and transforms L-arogenate to L-tyrosine. Is not able to utilize NADP(+) instead of NAD(+) as cosubstrate.
  catalytic activity: L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH (RHEA:12256)
  catalytic activity: NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (RHEA:13869)
  subunit: Homodimer.

O67636 prephenate dehydrogenase (EC 1.3.1.12) from Aquifex aeolicus (see paper)
Aligns to 45:199 / 311 (49.8%), covers 99.4% of PF02153, 189.0 bits

tyrAa / P73906 arogenate dehydrogenase monomer (EC 1.3.1.78) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
P73906 arogenate dehydrogenase (NADP+) (EC 1.3.1.78) from Synechocystis sp. PCC 6803 (see paper)
Aligns to 15:164 / 279 (53.8%), covers 99.4% of PF02153, 179.7 bits

Q81P63 prephenate dehydrogenase (EC 1.3.1.12) from Bacillus anthracis (see paper)
Aligns to 29:184 / 378 (41.3%), covers 99.4% of PF02153, 147.5 bits

Q8DUW0 prephenate dehydrogenase (EC 1.3.1.12) from Streptococcus mutans (see paper)
Aligns to 18:175 / 368 (42.9%), covers 99.4% of PF02153, 120.9 bits

J9XQS6 prephenate dehydrogenase (EC 1.3.1.12) from uncultured bacterium (see paper)
Aligns to 30:156 / 287 (44.3%), covers 74.0% of PF02153, 100.7 bits

novF / Q9L9G2 prephenate dehydrogenase (EC 1.3.1.12) from Streptomyces niveus (see paper)
Aligns to 16:163 / 362 (40.9%), covers 97.4% of PF02153, 89.2 bits

A0A101IGG2 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Methanothrix harundinacea (see paper)
Aligns to 26:168 / 310 (46.1%), covers 99.4% of PF02153, 87.7 bits

TyrAAT1 / Q944B6 arogenate dehydrogenase (EC 1.3.1.78) from Arabidopsis thaliana (see paper)
TYRA1_ARATH / Q944B6 Arogenate dehydrogenase 1, chloroplastic; TYRATC; TyrAAT1; EC 1.3.1.78 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q944B6 arogenate dehydrogenase (NADP+) (EC 1.3.1.78) from Arabidopsis thaliana (see 2 papers)
2 alignments in 67:528 / 640 (41.7%), covering up to 72.1% of PF02153, 74.3 bits

• function: Involved in the biosynthesis of tyrosine. Has no prephenate dehydrogenase activity.
  catalytic activity: L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH (RHEA:15417)

Ga0059261_2298 prephenate and/or arogenate dehydrogenase (EC 1.3.1.13) from Sphingomonas koreensis DSMZ 15582
Aligns to 16:149 / 249 (53.8%), covers 83.8% of PF02153, 68.8 bits

• mutant phenotype: Important for fitness in defined media. 31% identical to arogenate dehydrogenase from Arabidopsis (Q9LMR3). The substrate could be prephenate (dehydrogenation first) or arogenate (transamination followed by dehydrogenation).

TYRA_MYCTU / O69721 Prephenate dehydrogenase; PDH; EC 1.3.1.12 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
Aligns to 22:175 / 323 (47.7%), covers 92.2% of PF02153, 68.3 bits

• function: Catalyzes the NAD(+)-dependent conversion of prephenate to p- hydroxyphenylpyruvate, with the elimination of carbon dioxide. Is a key regulatory enzyme in tyrosine biosynthesis. Displays no chorismate mutase (CM) activity, in contrast to TyrA from E.coli and some other bacteria, that are bifunctional and possess a CM domain.
  catalytic activity: NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (RHEA:13869)

E1R5M5 arogenate dehydrogenase [NAD(P)+] (EC 1.3.1.79) from Sediminispirochaeta smaragdinae (see paper)
Aligns to 18:156 / 251 (55.4%), covers 98.7% of PF02153, 62.0 bits

DVU0464 prephenate and/or arogenate dehydrogenase from Desulfovibrio vulgaris Hildenborough JW710
Aligns to 20:141 / 255 (47.8%), covers 44.2% of PF02153, 62.0 bits

• mutant phenotype: # important for fitness in defined media, and rescued by added tyrosine. This is the second or third step in tyrosine synthesis from chorismate via prephenate; it is not clear if dehydrogenation or transamination occurs first.

A8AAX2 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Ignicoccus hospitalis (see 2 papers)
Aligns to 111:252 / 348 (40.8%), covers 67.5% of PF02153, 55.4 bits

P43902 prephenate dehydrogenase (EC 1.3.1.12) from Haemophilus influenzae (see paper)
Aligns to 117:239 / 377 (32.6%), covers 43.5% of PF02153, 49.9 bits

TyrA / b2600 fused chorismate mutase/prephenate dehydrogenase (EC 5.4.99.5; EC 1.3.1.12) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
tyrA / P07023 fused chorismate mutase/prephenate dehydrogenase (EC 5.4.99.5; EC 1.3.1.12) from Escherichia coli (strain K12) (see 12 papers)
Aligns to 124:240 / 373 (31.4%), covers 63.6% of PF02153, 47.2 bits

BT3933 prephenate dehydrogenase (EC 1.3.1.13) from Bacteroides thetaiotaomicron VPI-5482
Aligns to 24:151 / 257 (49.8%), covers 68.8% of PF02153, 41.9 bits

• mutant phenotype: Important for fitness in defined media. Distantly related (under 25% identity) to the prephenate dehydrogenase portion of E. coli tyrA. This is sometimes annotated as chorismate mutase as well, but it lacks that domain.

O30012 prephenate dehydrogenase (EC 1.3.1.12); prephenate dehydratase (EC 4.2.1.51); chorismate mutase (EC 5.4.99.5) from Archaeoglobus fulgidus (see paper)
Aligns to 29:138 / 620 (17.7%), covers 48.7% of PF02153, 39.5 bits

TyrAAT2 / Q9LMR3 arogenate dehydrogenase (EC 1.3.1.78) from Arabidopsis thaliana (see paper)
TYRA2_ARATH / Q9LMR3 Arogenate dehydrogenase 2, chloroplastic; TyrAAT2; EC 1.3.1.78 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LMR3 arogenate dehydrogenase (NADP+) (EC 1.3.1.78) from Arabidopsis thaliana (see 2 papers)
Aligns to 73:223 / 358 (42.2%), covers 95.5% of PF02153, 38.3 bits

• function: Involved in the biosynthesis of tyrosine. Has a weak prephenate dehydrogenase activity.
  catalytic activity: L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH (RHEA:15417)

AroDH-1 / B4FY98 arogenate dehydrogenase 1 (EC 1.3.1.43) from Zea mays (see paper)
Aligns to 96:230 / 360 (37.5%), covers 69.5% of PF02153, 37.9 bits

B6SS03 arogenate dehydrogenase [NAD(P)+] (EC 1.3.1.79) from Zea mays (see paper)
Aligns to 83:197 / 349 (33.0%), covers 68.8% of PF02153, 37.3 bits

G7J2E9 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Medicago truncatula (see paper)
Aligns to 22:146 / 268 (46.6%), covers 55.2% of PF02153, 35.2 bits

PAPC_STRPR / P72540 4-amino-4-deoxyprephenate dehydrogenase; EC 1.3.1.121 from Streptomyces pristinaespiralis (see paper)
Aligns to 23:165 / 296 (48.3%), covers 62.3% of PF02153, 34.0 bits

• function: Involved in pristinamycin I biosynthesis (PubMed:9044253). Probably catalyzes the formation of 3-(4-aminophenyl)pyruvate from 4- amino-4-deoxyprephenate (Probable).
  catalytic activity: 4-amino-4-deoxyprephenate + NAD(+) = 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH (RHEA:59380)

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