Family Search for PF03690 (UPF0160)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF03690 hits 20 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

MYG1_MOUSE / Q9JK81 MYG1 exonuclease; Protein Gamm1; EC 3.1.-.- from Mus musculus (Mouse) (see 3 papers)
Aligns to 45:365 / 380 (84.5%), covers 99.7% of PF03690, 459.0 bits

• function: 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (PubMed:31081026).
  disruption phenotype: Mutants are vital, fertile and display no gross abnormalities. They show an inconsistent pattern of altered anxiety- like behavior. Mutant males are significantly less anxious than their wild-type littermates, females show increased anxiety in the locomotor activity arena.

MYG1_HUMAN / Q9HB07 MYG1 exonuclease; EC 3.1.-.- from Homo sapiens (Human) (see 4 papers)
Aligns to 46:366 / 376 (85.4%), covers 99.7% of PF03690, 455.2 bits

• function: 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).

YEY6_YEAST / P40093 MYG1 protein YER156C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Aligns to 16:337 / 338 (95.3%), covers 100.0% of PF03690, 438.0 bits

Or search for genetic data about PF03690 in the Fitness Browser