Family Search for PF05603 (Hikeshi-like_N)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF05603 hits 8 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

HIKES_HUMAN / Q53FT3 Protein Hikeshi from Homo sapiens (Human) (see 3 papers)
Aligns to 5:132 / 197 (65.0%), covers 96.2% of PF05603, 132.2 bits

• function: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin- dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
  subunit: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins (PubMed:25760597). Interacts with ATP- bound HSP70 proteins (PubMed:22541429). Interacts with NUP62 and NUP153 (via F-X-F-G repeats) (PubMed:22541429). Interacts with HSPA8 (PubMed:25760597).

HIKES_MOUSE / Q9DD02 Protein Hikeshi; Lethal gene on chromosome 7 Rinchik 6 protein from Mus musculus (Mouse) (see 2 papers)
Aligns to 5:132 / 197 (65.0%), covers 95.5% of PF05603, 131.7 bits

• function: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin- dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). May also be indirectly required for organization and/or function of the secretory apparatus in Club cells in lung.
  subunit: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats). Interacts with HSPA8.
  disruption phenotype: Mice display severe emphysematous enlargement of the distal respiratory sacs at birth. Club cells display enlargement and disorganization of the Golgi complex and formation of aberrant vesicular structures.

OPI10_SCHPO / O60175 Protein OPI10 homolog from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 5:121 / 200 (58.5%), covers 94.0% of PF05603, 126.0 bits

OPI10_YEAST / Q08202 Protein OPI10; Overproducer of inositol protein 10 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 5:155 / 246 (61.4%), covers 99.2% of PF05603, 122.5 bits

• function: Involved in phospholipid biosynthesis.

Or search for genetic data about PF05603 in the Fitness Browser