Family Search for PF06625 (DUF1151)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF06625 hits 8 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

F107B_MOUSE / Q3TGF2 Protein FAM107B from Mus musculus (Mouse) (see paper)
Aligns to 12:120 / 131 (83.2%), covers 99.1% of PF06625, 136.0 bits

F107A_HUMAN / O95990 Actin-associated protein FAM107A; Down-regulated in renal cell carcinoma 1; Protein TU3A from Homo sapiens (Human) (see 5 papers)
Aligns to 26:133 / 144 (75.0%), covers 99.1% of PF06625, 131.3 bits

• function: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580).
  subunit: Interacts with ACTB (PubMed:21969592, PubMed:28604741). Interacts with COMMD1; this interaction stabilizes COMMD1 in the nucleus (PubMed:28604741). Interacts with MAP1A (PubMed:20543869). Interacts with PRDX1 (PubMed:21969592). Interacts with F-actin (By similarity).

F107A_RAT / M0R3K6 Actin-associated protein FAM107A from Rattus norvegicus (Rat) (see paper)
Aligns to 13:120 / 131 (82.4%), covers 99.1% of PF06625, 129.6 bits

• function: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin- dependent manner. May play a role in tumor development (By similarity).
  subunit: Interacts with ACTB. Interacts with COMMD1; this interaction stabilizes COMMD1 in the nucleus. Interacts with MAP1A. Interacts with PRDX1 (By similarity). Interacts with F-actin (By similarity).

F107A_MOUSE / Q78TU8 Actin-associated protein FAM107A from Mus musculus (Mouse) (see 2 papers)
Aligns to 26:133 / 144 (75.0%), covers 99.1% of PF06625, 128.5 bits

• function: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics (PubMed:21969592). Mediates polymerization of globular actin to F-actin (PubMed:21969592). Also binds to, stabilizes and bundles F-actin (PubMed:21969592). Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (PubMed:21969592). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity).
  subunit: Interacts with ACTB (PubMed:21969592). Interacts with F-actin (PubMed:21969592). Interacts with PRDX1 (PubMed:21969592). Interacts with COMMD1; this interaction stabilizes COMMD1 in the nucleus (By similarity). Interacts with MAP1A (By similarity).

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