Family Search for PF06722 (EryCIII-like

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Family Search for PF06722 (EryCIII-like_C)

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PF06722 hits 508 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

ERYC3_SACEN / A4F7P3 3-alpha-mycarosylerythronolide B desosaminyl transferase; Desosaminyl transferase EryCIII; Erythromycin biosynthesis protein CIII; EC 2.4.1.278 from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see 3 papers)
Aligns to 269:413 / 421 (34.4%), covers 99.3% of PF06722, 217.2 bits

function: Catalyzes the conversion of alpha-L-mycarosylerythronolide B into erythromycin D in the erythromycin biosynthesis pathway.
catalytic activity: 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+) (RHEA:32091)
subunit: Heterotetramer composed of EryCII and EryCIII.

eryBV / A4F7N6 dTDP-L-mycarosyl: erythronolide B mycarosyltransferase (EC 2.4.1.328) from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see 2 papers)
ERYBV_SACER / O33939 Erythronolide mycarosyltransferase; EC 2.4.1.328 from Saccharopolyspora erythraea (Streptomyces erythraeus) (see paper)
Aligns to 268:409 / 415 (34.2%), covers 99.3% of PF06722, 209.3 bits

function: Involved in the biosynthesis of the macrolide antibiotic erythromycin. Catalyzes the reversible transfer of mycarosyl from dTDP- beta-L-mycarose to erythronolide B to yield 3-alpha-L- mycarosylerythronolide B. It can also use TDP-beta-L-cladinose.
catalytic activity: dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L- mycarosylerythronolide B + dTDP + H(+) (RHEA:41576)

cloM / Q8GHC2 L-demethylnoviosyl:clorobiocic acid transferase (EC 2.4.1.302) from Streptomyces roseochromogenus subsp. oscitans (see paper)
Aligns to 229:372 / 390 (36.9%), covers 99.3% of PF06722, 204.5 bits

iroB / A0A0H2V630 enterobactin C-glucosyltransferase (EC 2.4.1.369) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see 3 papers)
IROB_ECOL6 / A0A0H2V630 Enterobactin C-glucosyltransferase; Ent C-glucosyltransferase; EC 2.4.1.369 from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see 3 papers)
A0A0H2V630 enterobactin C-glucosyltransferase (EC 2.4.1.369) from Escherichia coli O6:H1 (see 2 papers)
Aligns to 227:367 / 371 (38.0%), covers 99.3% of PF06722, 181.4 bits

function: Catalyzes the successive monoglucosylation, diglucosylation and triglucosylation of enterobactin (Ent) (PubMed:15598734, PubMed:24960592). Transfers glucosyl groups from uridine-5'- diphosphoglucose (UDP-Glc) to C5 of one, two or three of the 2,3- dihydroxybenzoyl (DHB) units of Ent to yield monoglucosyl-C-Ent (MGE), diglucosyl-C-Ent (DGE) and triglucosyl-C-Ent (TGE) (PubMed:15598734, PubMed:24960592). Glucosylation decreases the membrane affinity of Ent and increases the iron acquisition rate (PubMed:17163637).
catalytic activity: enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP (RHEA:24448)
catalytic activity: monoglucosyl-enterobactin + UDP-alpha-D-glucose = diglucosyl- enterobactin + H(+) + UDP (RHEA:59096)
catalytic activity: diglucosyl-enterobactin + UDP-alpha-D-glucose = H(+) + triglucosyl-enterobactin + UDP (RHEA:59100)

oleG2 / O87831 oleandolide olivosyltransferase from Streptomyces antibioticus (see 3 papers)
Aligns to 267:411 / 426 (34.0%), covers 99.3% of PF06722, 181.1 bits

novM / Q9L9F5 4-O-demethyl-L-noviosyl transferase (EC 2.4.1.302) from Streptomyces niveus (see paper)
NOVM_STRNV / Q9L9F5 L-demethylnoviosyl transferase; Novobiocin biosynthesis protein M; EC 2.4.1.302 from Streptomyces niveus (Streptomyces spheroides) (see 3 papers)
Aligns to 229:371 / 379 (37.7%), covers 97.2% of PF06722, 175.2 bits

function: Catalyzes the transfer of L-noviose from dTDP-4-O-demethyl- beta-L-noviose to the phenolic oxygen of novobiocic acid, creating the full ABC ring system in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Also shows activity with variant coumarin aglycones, suggesting it may be a promiscuous catalyst for noviosylation of a range of planar scaffolds. Does not show activity with TDP-L-rhamnose.
catalytic activity: dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = desmethyldescarbamoylnovobiocin + dTDP + H(+) (RHEA:36695)

oleG1 / O87830 L-oleandrosyl-oleandolide desosaminyltransferase from Streptomyces antibioticus (see 2 papers)
Aligns to 268:413 / 426 (34.3%), covers 99.3% of PF06722, 166.5 bits

megDI / Q9F839 dTDP-L-megosamine:erythromycin C L-megosaminyltransferase from Micromonospora megalomicea subsp. nigra (see 2 papers)
Aligns to 272:415 / 436 (33.0%), covers 99.3% of PF06722, 166.2 bits

aknS / Q9L4U6 L-rhodosaminyltransferase (EC 2.4.1.326) from Streptomyces galilaeus (see 4 papers)
AKNS_STRGJ / Q9L4U6 Aklavinone 7-beta-L-rhodosaminyltransferase; EC 2.4.1.326 from Streptomyces galilaeus (see 2 papers)
Aligns to 279:423 / 443 (32.7%), covers 99.3% of PF06722, 158.0 bits

function: Involved in the biosynthesis of the anthracycline antitumor agent aclacinomycin A. Catalyzes the transfer of the proximal deoxyhexose, L-rhodosamine, from dTDP-beta-L-rhodosamine to the C7-OH of aklavinone aglycone to yield aclacinomycin T (rhodosaminyl- aklavinone). It can also use dTDP-2-deoxy-beta-L-fucose, TDP-2- deoxyfucose, dTDP-4-amino-2-deoxyrhamnose, TDP-L-rhodosamine as sugar donor and epsilon-rhodomycinone as sugar acceptor.
catalytic activity: aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+) (RHEA:41564)

DES7_STRVZ / Q9ZGH7 10-deoxymethynolide desosaminyltransferase; EC 2.4.1.277 from Streptomyces venezuelae (see 5 papers)
Q9ZGH7 10-deoxymethynolide desosaminyltransferase (EC 2.4.1.277); 3-alpha-mycarosylerythronolide B desosaminyl transferase (EC 2.4.1.278); erythronolide mycarosyltransferase (EC 2.4.1.328) from Streptomyces venezuelae (see 8 papers)
Aligns to 269:413 / 426 (34.0%), covers 98.6% of PF06722, 153.7 bits

function: Involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin. Catalyzes the attachment of dTDP-D-desosamine onto 12- and 14-membered macrolactone rings 10-deoxymethynolide and narbonolide to produce 10-deoxymethymycin (YC-17) and narbomycin. DesVII is unique among glycosyltransferases in that it requires an additional protein component, DesVIII, for its activity. DesVII can recognize and process not only cyclic substrates of different ring size, but also a variety of linear substrates albeit with reduced, but measurable activities (PubMed:18548476). Both L- sugars and D-sugars are recognized as substrates and variant substitutions at C-3 and C-4 are tolerated, but deoxygenation at C-6 is required (PubMed:16538696).
catalytic activity: 10-deoxymethynolide + dTDP-alpha-D-desosamine = 10- deoxymethymycin + dTDP + H(+) (RHEA:31627)
subunit: Forms a complex with DesVIII.
disruption phenotype: Cells lacking this gene are not able to produce glycosylated macrolides.

mycB / Q83WE1 protomycinolide IV desosaminyltransferase from Micromonospora griseorubida (see 2 papers)
Aligns to 269:413 / 428 (33.9%), covers 97.9% of PF06722, 151.6 bits

tylM2 / P95747 tylactone mycaminosyltransferase (EC 2.4.1.316) from Streptomyces fradiae (see paper)
TYLM2_STRFR / P95747 Tylactone mycaminosyltransferase; EC 2.4.1.316 from Streptomyces fradiae (Streptomyces roseoflavus) (see paper)
P95747 tylactone mycaminosyltransferase (EC 2.4.1.316) from Streptomyces fradiae (see paper)
Aligns to 293:437 / 452 (32.1%), covers 99.3% of PF06722, 150.3 bits

function: Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of alpha-D-mycaminosyl from dTDP-alpha-D-mycaminose to the 5- hydroxyl group of tylactone to yield 5-O-mycaminosytylactone. It can also accept 16-membered tylactone and 12-membered ring macrolide.
catalytic activity: dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D- mycaminosyltylactone + dTDP + H(+) (RHEA:21468)

dnmS / Q54824 dTDP-daunosamine transferase from Streptomyces peucetius (see 2 papers)
DNRS_STRPE / Q54824 TDP-daunosamine transferase DnrS; 2,3,6-trideoxy-3-aminohexose transferase; EC 2.4.1.- from Streptomyces peucetius (see 2 papers)
Aligns to 271:417 / 431 (34.1%), covers 99.3% of PF06722, 148.1 bits

function: Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the addition of the TDP activated glycoside, L-daunosamine-TDP (2,3,6- trideoxy-3-aminohexose-TDP) at position C-7 of epsilon-rhodomycinone to yield rhodomycin D. Glycosylation is a prerequisite for biological activity of anthracyclines and requires DnrQ which seems to act as an activator.
catalytic activity: dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D (RHEA:45760)

aknK / Q9L555 L-rhodinosyltransferase (EC 2.4.1.327) from Streptomyces galilaeus (see paper)
AKNK_STRGJ / Q9L555 Aclacinomycin-T 2-deoxy-L-fucose transferase; AknK; L-2-deoxyfucosyltransferase; EC 2.4.1.327 from Streptomyces galilaeus (see paper)
Aligns to 277:422 / 440 (33.2%), covers 99.3% of PF06722, 147.9 bits

function: Involved in the biosynthesis of the trisaccharide moiety characteristic of the antitumor drug aclacinomycins. In the first reaction, AknK catalyzes the transfer of 2-deoxy-beta-L-fucose from the activated donor dTDP-2-deoxy-beta-L-fucose to the mono-glycosylated aclacinomycin T (rhodosaminyl aklavinone), forming the di-glycosylated aclacinomycin S (L-2-deoxyfucosyl-L-rhodosaminyl aklavinone). It can also catalyze the addition of an alternate dTDP-L-sugar, dTDP-L- daunosamine, to aclacinomycin T and the addition of 2-deoxy-beta-L- fucose to the mono-glycosylated aglycones (monoglycosylated anthracyclines) such as daunomycin (daunorubicin), adriamycin (doxorubicin) and idarubicin. In vitro, AknK also catalyzes the addition of a second L-2-deoxyfucosyl moiety from dTDP-2-deoxy-beta-L- fucose, albeit with reduced activity, to the natural disaccharide chain of aclacinomycin S to produce L-deoxyfucosyl-L-deoxyfucosyl-L- rhodosaminyl aklavinone (2-deoxy-alpha-D-fucosyl-aclacinomycin S), a variant of the natural aclacinomycin A.
catalytic activity: aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+) (RHEA:41568)

spnP / Q9ALN7 spinosyn forosaminyltransferase from Saccharopolyspora spinosa (see 2 papers)
Aligns to 294:439 / 455 (32.1%), covers 99.3% of PF06722, 129.8 bits

mtmGIII / Q194P9 MtmGIII from Streptomyces argillaceus (see paper)
Aligns to 245:389 / 396 (36.6%), covers 98.6% of PF06722, 121.5 bits

mtmGI / Q194P5 premithramycin A3:dTDP-D-olivose D-olivosyltransferase from Streptomyces argillaceus (see paper)
Aligns to 232:378 / 393 (37.4%), covers 97.9% of PF06722, 113.0 bits

elmGT / Q9F2F9 8-demethyltetracenomycin C rhamnosyltransferase (EC 2.4.1.331) from Streptomyces olivaceus (see 2 papers)
ELMGT_STROV / Q9F2F9 Elloramycin glycosyltransferase ElmGT; EC 2.4.1.331 from Streptomyces olivaceus (see 2 papers)
Q9F2F9 8-demethyltetracenomycin C L-rhamnosyltransferase (EC 2.4.1.331) from Streptomyces olivaceus (see 5 papers)
Aligns to 234:372 / 382 (36.4%), covers 93.8% of PF06722, 108.2 bits

function: Glycosyltransferase that transfers an L-rhamnose moiety from dTDP-L-rhamnose to the elloramycin aglycone 8-demethyl-tetracenomycin C (8DMTC) in elloramycin biosynthesis, an antitumor polyketide. Possesses donor substrate flexibility: able to transfer at least 11 different sugars to 8DMTC, such as NDP-D-glucose, as well as NDP-L-digitoxose, including both L- and D-isomeric forms of some sugars.
catalytic activity: 8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8- demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+) (RHEA:42848)

spnG / Q9ALM8 spinosyn rhamnosyltransferase subunit from Saccharopolyspora spinosa (see paper)
Aligns to 239:385 / 390 (37.7%), covers 91.0% of PF06722, 107.9 bits

jadS / Q939Q6 2,6-dideoxy-α-L-ribohexopyranosyl-O-glycosyltransferase from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see 2 papers)
Aligns to 242:391 / 396 (37.9%), covers 97.9% of PF06722, 105.1 bits

mtmGII / Q194P6 3A-deolivosylpremithramycin B:dTDP-D-olivose D-olivosyltransferase from Streptomyces argillaceus (see paper)
Aligns to 232:377 / 379 (38.5%), covers 95.2% of PF06722, 104.9 bits

sibH / C0LTM2 sibiromycin sibirosaminetransferase from Streptosporangium sibiricum (see paper)
Aligns to 241:387 / 392 (37.5%), covers 97.9% of PF06722, 101.4 bits

mtmGIV / Q194Q0 MtmGIV from Streptomyces argillaceus (see 2 papers)
Aligns to 254:405 / 407 (37.3%), covers 98.6% of PF06722, 94.5 bits

rebG / Q8KHE4 RebG N-glycosyl transferase (EC 4.3.3.5) from Lentzea aerocolonigenes (see 2 papers)
REBG_LENAE / Q8KHE4 4'-demethylrebeccamycin synthase; Arcyriaflavin A N-glycosyltransferase; EC 4.3.3.5 from Lentzea aerocolonigenes (Lechevalieria aerocolonigenes) (Saccharothrix aerocolonigenes) (see 3 papers)
Q8KHE4 4'-demethylrebeccamycin synthase (EC 4.3.3.5) from Lentzea aerocolonigenes (see paper)
Aligns to 275:420 / 421 (34.7%), covers 88.3% of PF06722, 79.5 bits

function: Catalyzes the penultimate step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid that inhibits topoisomerase 1. Has a wide substrate range, including staurosporine aglycone, EJG- III-108A, J-104303, 6-N-methyl-arcyriaflavin and indolo-[2,3-a]- carbazole.
catalytic activity: 4'-demethylrebeccamycin + H2O = beta-D-glucose + dichloroarcyriaflavin A (RHEA:27397)

staG / Q83WG5 K252c N-glycosyltransferase from Streptomyces sp. TP-A0274 (see paper)
Aligns to 288:432 / 446 (32.5%), covers 93.1% of PF06722, 77.7 bits

oleI / Q3HTL7 oleandomycin glycosyltransferase from Streptomyces antibioticus (see 3 papers)
Aligns to 274:417 / 424 (34.0%), covers 89.0% of PF06722, 75.2 bits

rhlB / Q51560 RhlB rhamnosyltransferase from Pseudomonas aeruginosa (see 4 papers)
Aligns to 274:413 / 426 (32.9%), covers 72.4% of PF06722, 72.2 bits

NDPGT_BACSU / O34539 NDP-glycosyltransferase YjiC; UDP-glycosyltransferase YjiC; EC 2.4.1.384 from Bacillus subtilis (strain 168) (see 3 papers)
O34539 NDP-glycosyltransferase (EC 2.4.1.384) from Bacillus subtilis (see 2 papers)
Aligns to 246:384 / 392 (35.5%), covers 75.2% of PF06722, 68.8 bits

function: Glycosyltransferase that can glycosylate a wide range of substrates, including various flavonoids, phenyl ketones, curcuminoid, lignins, zingerone, triterpenes, stilbene and anthraquinone, using UDP- glucose or ADP-glucose as sugar donor (PubMed:28315700, PubMed:33152360). It also exhibits O-, N- and S-glycosylation activities towards simple aromatics (PubMed:28315700). In vivo, the broad acceptor tolerance of YjiC might function as a detoxification agent against exogenous xenobiotics to make the strain adaptable to the changeable environment (Probable).
catalytic activity: an NDP-glycose + an acceptor = a glycosylated acceptor + NDP.
subunit: Monomer.

tylCV / Q9XC67 demethyllactenocin mycarosyltransferase (EC 2.4.1.318) from Streptomyces fradiae (see paper)
TYLCV_STRFR / Q9XC67 Demethyllactenocin mycarosyltransferase; EC 2.4.1.318 from Streptomyces fradiae (Streptomyces roseoflavus) (see paper)
Q9XC67 demethyllactenocin mycarosyltransferase (EC 2.4.1.318) from Streptomyces fradiae (see paper)
Aligns to 331:456 / 461 (27.3%), covers 80.0% of PF06722, 67.0 bits

function: Involved in the biosynthesis of mycarose which is a 6- deoxyhexose sugar required during production of the macrolide antibiotic tylosin. Catalyzes the transfer of L-mycarosyl from dTDP- beta-L-mycarose to demethyllactenocin to yield demethylmacrocin.
catalytic activity: demethyllactenocin + dTDP-beta-L-mycarose = demethylmacrocin + dTDP + H(+) (RHEA:14649)
disruption phenotype: Cells lacking this gene accumulate desmycosin (tylosin B).

Rv2958c / P9WFR1 mycoside B rhamnosyltransferase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
GLTR2_MYCTU / P9WFR1 PGL/p-HBAD biosynthesis glycosyltransferase Rv2958c; EC 2.4.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Aligns to 283:426 / 428 (33.6%), covers 87.6% of PF06722, 66.8 bits

function: Involved in glycosylation steps downstream of mono-O-methyl- glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl- rhamnosyl-phenolphthiocerol dimycocerosate (mycoside B) during the p- hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.

Rv2962c / P9WN09 dimycocerosyl phenolphthiocerol rhamnosyltransferase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
RNTF_MYCTU / P9WN09 PGL/p-HBAD biosynthesis rhamnosyltransferase; EC 2.4.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Aligns to 294:437 / 449 (32.1%), covers 87.6% of PF06722, 66.6 bits

function: Catalyzes the transfer of the first rhamnosyl residue on p- hydroxybenzoic acid or phenolphthiocerol derivatives to form, after O- methylation at position 2 of the sugar unit, mono-O-methyl-glycosyl-p- hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl- phenolphthiocerol dimycocerosate (also called mycoside B) during p- hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.

UGT48_CAEEL / Q18081 Putative UDP-glucuronosyltransferase ugt-48; UDPGT 48; EC 2.4.1.17 from Caenorhabditis elegans (see paper)
Aligns to 315:464 / 526 (28.5%), covers 85.5% of PF06722, 63.1 bits

catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
subunit: Interacts with cmd-1 in the presence of Ca(2+).

UGTB1_STABO / E9L011 UDP-glucosyltransferase B1; GTII; EC 2.4.1.- from Starmerella bombicola (Yeast) (Candida bombicola) (see 4 papers)
Aligns to 287:420 / 432 (31.0%), covers 78.6% of PF06722, 63.0 bits

function: Catalyzes the second glycosylation step of sophorolipid biosynthesis, the further glucosylation of the previoulsy formed glucolipid to give rise to an acidic sophorolipid.
catalytic activity: (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP- alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP (RHEA:60964)

UGTA1 / E7CQW6 UDP-glucose:hydroxy fatty acid glucosyltransferase from Starmerella bombicola (see 3 papers)
UGTA1_STABO / E7CQW6 UDP-glucosyltransferase A1; GTI; EC 2.4.1.- from Starmerella bombicola (Yeast) (Candida bombicola) (see 5 papers)
Aligns to 300:434 / 463 (29.2%), covers 75.9% of PF06722, 60.7 bits

function: Catalyzes the first glycosylation step of sophorolipid biosynthesis, the coupling of glucose to a hydroxylated fatty acid to give rise to a glucolipid (PubMed:21073653, PubMed:23516968). Can glycosylate all hydroxyl fatty acids generated by cytochrome P450 monooxygenases CYP52M1, CYP52N1 and CYP52E3 into their corresponding glucolipids. Main products are 17-O- and 18-O-(beta-D-glucopyranosyl)- octadecenoic acids (PubMed:24242247, PubMed:26298016).
catalytic activity: 18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-18- hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP (RHEA:60960)
catalytic activity: 17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-17- hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP (RHEA:60956)

Q64634 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 3 papers)
Aligns to 333:456 / 530 (23.4%), covers 73.8% of PF06722, 60.5 bits

UD11_RAT / Q64550 UDP-glucuronosyltransferase 1A1; UGT1A1; B1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; EC 2.4.1.17 from Rattus norvegicus (Rat) (see paper)
Q64550 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 4 papers)
Aligns to 322:461 / 535 (26.2%), covers 73.8% of PF06722, 60.4 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:8554318). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:8554318). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (By similarity). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (By similarity). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (By similarity). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (By similarity). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53072)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
subunit: Homodimers. Homooligomer. Interacts with UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers.

Q64638 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see paper)
Aligns to 334:457 / 531 (23.4%), covers 73.8% of PF06722, 60.3 bits

P20720 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see paper)
Aligns to 336:459 / 533 (23.3%), covers 73.8% of PF06722, 60.0 bits

Q64633 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 2 papers)
Aligns to 334:457 / 531 (23.4%), covers 73.8% of PF06722, 59.9 bits

UD19_MOUSE / Q62452 UDP-glucuronosyltransferase 1A9; UGT1A9; UDP-glucuronosyltransferase 1-7; UDPGT; UDP-glucuronosyltransferase 1-9; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UGT1A12; UGTP4; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Aligns to 315:454 / 528 (26.5%), covers 73.8% of PF06722, 59.8 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Also metabolizes mycophenolic acid, an immunosuppressive agent.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53040)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O- (beta-D-glucuronate) + H(+) + UDP (RHEA:53060)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
subunit: Homodimer. Homooligomer. Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 to form heterodimers.

Q64637 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 2 papers)
Aligns to 334:457 / 531 (23.4%), covers 73.8% of PF06722, 59.7 bits

P08430 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 2 papers)
Aligns to 332:455 / 529 (23.4%), covers 73.8% of PF06722, 59.7 bits

oleD / Q53685 oleandomycin glycosyltransferase from Streptomyces antibioticus (see 4 papers)
Aligns to 263:396 / 430 (31.2%), covers 75.2% of PF06722, 59.7 bits

UD17_MOUSE / Q6ZQM8 UDP-glucuronosyltransferase 1A7; UGT1A7; UDP-glucuronosyltransferase 1-7C; UDPGT 1-7C; UGT1*7C; UGT1-07C; UGT1.7C; UDP-glucuronosyltransferase 1A7C; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Aligns to 319:457 / 531 (26.2%), covers 73.8% of PF06722, 59.6 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
subunit: Homodimer. Homooligomer. Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers.

UD2A3_CAVPO / Q9R110 UDP-glucuronosyltransferase 2A3; UDPGT 2A3; EC 2.4.1.17 from Cavia porcellus (Guinea pig) (see paper)
Aligns to 323:462 / 530 (26.4%), covers 73.8% of PF06722, 59.3 bits

function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

UD11_MOUSE / Q63886 UDP-glucuronosyltransferase 1A1; UGT1A1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UGTBR1; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Q63886 glucuronosyltransferase (EC 2.4.1.17) from Mus musculus (see paper)
Aligns to 322:461 / 535 (26.2%), covers 73.8% of PF06722, 59.3 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (By similarity). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (By similarity). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (By similarity). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (By similarity). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (By similarity). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (By similarity). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53072)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
subunit: Homodimers. Homooligomer. Interacts with UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers.

Q95M37 glucuronosyltransferase (EC 2.4.1.17) from Canis lupus familiaris (see paper)
Aligns to 311:454 / 528 (27.3%), covers 73.1% of PF06722, 59.1 bits

UD16_MOUSE / Q64435 UDP-glucuronosyltransferase 1-6; UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; Phenol UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1A6; UGT1A6; UGP1A1; UGT1A7; EC 2.4.1.17 from Mus musculus (Mouse) (see 2 papers)
Q64435 glucuronosyltransferase (EC 2.4.1.17) from Mus musculus (see paper)
Aligns to 318:457 / 531 (26.4%), covers 73.8% of PF06722, 58.8 bits

function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4- nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4- hydroxybiphenyl, androgens and estrogens are not substrates. 2- hydroxybiphenyl is an excellent substrate
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

UD12_MOUSE / P70691 UDP-glucuronosyltransferase 1-2; UDPGT 1-2; UGT1*2; UGT1-02; UGT1.2; Bilirubin-specific UDPGT; UDP-glucuronosyltransferase 1A2; UGT1A2; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Aligns to 320:459 / 533 (26.3%), covers 73.8% of PF06722, 58.8 bits

function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

asm25 / Q8KUH5 ansamitocin N-glucosyltransferase from Actinosynnema pretiosum subsp. auranticum (see 4 papers)
Aligns to 251:392 / 402 (35.3%), covers 97.2% of PF06722, 58.5 bits

EFUA_HORCR / A0A2Z4HPY4 Enfumafungin synthase efuA; Enfumafungin biosynthesis cluster protein A; Terpene cyclase-glycosyl transferase fusion protein efuA; EC 5.4.99.-; EC 2.4.1.- from Hormonema carpetanum (see paper)
Aligns to 983:1131 / 1314 (11.3%), covers 71.7% of PF06722, 58.4 bits

function: Terpene cyclase-glycosyl transferase fusion protein; part of the gene cluster that mediates the biosynthesis of enfumafungin, a glycosylated fernene-type triterpenoid with potent antifungal activity, mediated by its interaction with beta-1,3-glucan synthase and the fungal cell wall (PubMed:30051576). The pathway begins with the terpene cyclase-glycosyl transferase fusion protein that most likely uses 2,3- oxidosqualene as substrate and catalyzes glycosylation immediately after cyclization (Probable). The fernene glycoside then could be processed by the desaturase efuI which catalyzes isomerization of a double bond established by efuA to form the core structure (Probable). The latter would then undergo a series of hydroxylations in unknown order at C-2, C-19, C-23 and C-25, which would be catalyzed by two of the three cytochrome P450 monooxygenases efuB, efuG or efuH (Probable). The hydroxy-group at C-25 becomes oxidized by the dehydrogenase efuE to enable a spontaneous, non-enzymatic hemiacetal formation with C-23 (Probable). After hydroxylation at C-2, acetylation by the acetyltransferase efuC takes place (Probable). The final steps in enfumafungin biosynthesis require expansion of the 5-membered ring by lactonization via a Baeyer-Villiger reaction mediated by one of the BGC's cytochrome P450 monooxygenases (efuB, efuG or efuH) followed by ring cleavage (Probable). This type of reaction would establish a double bond between C-20 and C-21 which could be reduced by the reductase efuL to form the final product (Probable).
disruption phenotype: Abolishes the production of enfumafungin and loses antifungal activity.

Q6NUS8 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 2 papers)
Aligns to 314:456 / 523 (27.3%), covers 82.1% of PF06722, 58.4 bits

UD2A1_RAT / P36510 UDP-glucuronosyltransferase 2A1; UDPGT 2A1; UGT2A1; UGT-OLF; EC 2.4.1.17 from Rattus norvegicus (Rat) (see paper)
Aligns to 316:457 / 527 (26.9%), covers 72.4% of PF06722, 58.3 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterones) and estrogens (estradiol and estriol). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52920)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52872)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP (RHEA:52456)
catalytic activity: epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52568)
catalytic activity: lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl- 3-O-(beta-D-glucuronate) + UDP (RHEA:53028)
catalytic activity: lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52952)
catalytic activity: deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52948)
catalytic activity: hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP (RHEA:52964)
catalytic activity: hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta- D-glucuronate) + UDP (RHEA:52960)

UGT1A8 / Q9HAW9 UDP-glucuronosyltransferase 1-8 (EC 2.4.1.17) from Homo sapiens (see 4 papers)
UD18_HUMAN / Q9HAW9 UDP-glucuronosyltransferase 1A8; UGT1A8; UDP-glucuronosyltransferase 1-8; UDPGT 1-8; UGT1*8; UGT1-08; UGT1.8; UDP-glucuronosyltransferase 1-H; UGT-1H; UGT1H; EC 2.4.1.17 from Homo sapiens (Human) (see 12 papers)
Q9HAW9 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 20 papers)
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.2 bits

function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:16595710, PubMed:18052087, PubMed:18004212, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15472229, PubMed:16595710, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens (PubMed:15472229, PubMed:16595710, PubMed:18719240, PubMed:23288867). Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps (PubMed:16595710). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D- glucuronate) + H(+) + UDP (RHEA:52476)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52924)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53032)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53036)
catalytic activity: 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53040)
catalytic activity: 4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53052)
catalytic activity: 4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O- (beta-D-glucuronate) + H(+) + UDP (RHEA:53060)
catalytic activity: 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53072)
catalytic activity: 2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53064)
catalytic activity: 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53080)
catalytic activity: 4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53068)
catalytic activity: 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D- glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53000)
catalytic activity: 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP- alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D- glucuronosyl-(1->2)-glucuronate] + H(+) + UDP (RHEA:53388)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10 (PubMed:20610558).

UD19_HUMAN / O60656 UDP-glucuronosyltransferase 1A9; UGT1A9; UDP-glucuronosyltransferase 1-9; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UDP-glucuronosyltransferase 1-I; UGT-1I; UGT1I; lugP4; EC 2.4.1.17 from Homo sapiens (Human) (see 11 papers)
O60656 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 37 papers)
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.2 bits

function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:19545173). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10- hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:20610558). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53040)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O- (beta-D-glucuronate) + H(+) + UDP (RHEA:53060)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 (PubMed:20610558).

NDPGT_BACLD / Q65JC2 NDP-glycosyltransferase YjiC; UDP-glucosyltransferase YjiC; EC 2.4.1.384 from Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) (see 8 papers)
Q65JC2 flavone 7-O-beta-glucosyltransferase (EC 2.4.1.81) from Bacillus licheniformis (see paper)
Aligns to 245:389 / 396 (36.6%), covers 80.0% of PF06722, 58.1 bits

function: Glycosyltransferase that can glycosylate a wide range of substrates, including various flavonoids (flavones, flavonols, flavanones, flavanols, chalcones), isoflavonoids and stilbenes, to produce multiple glycosylated products (PubMed:23542617, PubMed:23974133, PubMed:24170092, PubMed:24893262, PubMed:25239890, PubMed:24949266, PubMed:27444326, PubMed:32238768). It can accept diverse nucleotide diphosphate-D/L-sugars as donors, including ADP-, GDP-, CDP-, TDP- or UDP-alpha-D-glucose, and catalyzes O-, N-, or S- glycosylation (PubMed:23542617, PubMed:23974133, PubMed:24170092, PubMed:24893262, PubMed:25239890, PubMed:24949266, PubMed:27444326, PubMed:32238768). In vitro, catalyzes the glycosylation of, among others, apigenin, 3-hydroxyflavone, phloretin or resveratrol, resulting in multiple glucosylated products, along with mono-, di-, tri- and tetraglucosides (PubMed:23542617, PubMed:23974133, PubMed:24170092, PubMed:24893262, PubMed:25239890, PubMed:27444326). Can also catalyze the glycosylation of the macrolide epothilone A with diverse NDP-D/L- sugars, forming different epothilone A glycoside derivatives (PubMed:24949266).
catalytic activity: an NDP-glycose + an acceptor = a glycosylated acceptor + NDP.

UD110_HUMAN / Q9HAW8 UDP-glucuronosyltransferase 1A10; UGT1A10; UDP-glucuronosyltransferase 1-10; UDPGT 1-10; UGT1*10; UGT1-10; UGT1.10; UDP-glucuronosyltransferase 1-J; UGT-1J; UGT1J; EC 2.4.1.17 from Homo sapiens (Human) (see 12 papers)
Q9HAW8 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 18 papers)
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.0 bits

function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:26220143). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:18719240, PubMed:23288867, PubMed:26220143). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52468)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52876)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52924)
catalytic activity: 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha- hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52448)
catalytic activity: estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D- glucuronate) + H(+) + UDP (RHEA:52476)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta- D-glucuronide + UDP (RHEA:63728)
catalytic activity: UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-1-N- beta-D-glucuronide (RHEA:63744)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9 (PubMed:20610558).

UD11_HUMAN / P22309 UDP-glucuronosyltransferase 1A1; UGT1A1; Bilirubin-specific UDPGT isozyme 1; hUG-BR1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UDP-glucuronosyltransferase 1A isoform 1; EC 2.4.1.17 from Homo sapiens (Human) (see 40 papers)
P22309 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 44 papers)
Aligns to 322:459 / 533 (25.9%), covers 73.8% of PF06722, 58.0 bits

function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:18004206, PubMed:18004212, PubMed:18719240, PubMed:19830808, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004206, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (PubMed:17187418, PubMed:18004206, PubMed:19830808). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10- hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53072)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2 (PubMed:17187418, PubMed:20610558). Isoform 1 also interacts with respective i2 isoforms of UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).

UD17_HUMAN / Q9HAW7 UDP-glucuronosyltransferase 1A7; UGT1A7; UDP-glucuronosyltransferase 1-7; UDPGT 1-7; UGT1*7; UGT1-07; UGT1.7; UDP-glucuronosyltransferase 1-G; UGT-1G; UGT1G; EC 2.4.1.17 from Homo sapiens (Human) (see 11 papers)
Q9HAW7 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 20 papers)
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.0 bits

function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:18052087, PubMed:18004212, PubMed:18674515, PubMed:18719240, PubMed:20610558, PubMed:23360619). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol (PubMed:18719240). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10- hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558, PubMed:23360619). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).

UD16_HUMAN / P19224 UDP-glucuronosyltransferase 1-6; UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; Phenol-metabolizing UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1-F; UGT-1F; UGT1F; UDP-glucuronosyltransferase 1A6; EC 2.4.1.17 from Homo sapiens (Human) (see 5 papers)
P19224 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 30 papers)
Aligns to 321:458 / 532 (25.9%), covers 73.8% of PF06722, 57.9 bits

function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
subunit: Isoform 1 interacts with isoform 3/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 3. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.

Q20CK7 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.8 bits

Q20CK6 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.8 bits

UD15_HUMAN / P35504 UDP-glucuronosyltransferase 1A5; UGT1A5; UDP-glucuronosyltransferase 1-5; UDPGT 1-5; UGT1*5; UGT1-05; UGT1.5; UDP-glucuronosyltransferase 1-E; UGT-1E; UGT1E; EC 2.4.1.17 from Homo sapiens (Human) (see 2 papers)
P35504 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 4 papers)
Aligns to 323:460 / 534 (25.8%), covers 73.8% of PF06722, 57.7 bits

function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18674515). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18674515). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-1-N- beta-D-glucuronide (RHEA:63744)
subunit: Homodimer (By similarity). Homooligomer (By similarity). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (By similarity). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (By similarity).

D2SMM6 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:459 / 528 (26.3%), covers 71.7% of PF06722, 57.6 bits

Q20CL4 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 333:460 / 534 (24.0%), covers 73.8% of PF06722, 57.6 bits

UGT1A3 / P35503 UDP-glucuronosyltransferase 1A3 (EC 2.4.1.17) from Homo sapiens (see 4 papers)
UD13_HUMAN / P35503 UDP-glucuronosyltransferase 1A3; UGT1A3; UDP-glucuronosyltransferase 1-3; UDPGT 1-3; UGT1*3; UGT1-03; UGT1.3; UDP-glucuronosyltransferase 1-C; UGT-1C; UGT1C; UDP-glucuronosyltransferase 1A isoform 3; EC 2.4.1.17 from Homo sapiens (Human) (see 9 papers)
P35503 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 26 papers)
Aligns to 323:460 / 534 (25.8%), covers 73.8% of PF06722, 57.6 bits

function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23756265, PubMed:23288867, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515).
function: [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D- glucuronate) + H(+) + UDP (RHEA:52476)
catalytic activity: chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP (RHEA:52940)
catalytic activity: deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52948)
catalytic activity: lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52952)
catalytic activity: hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl- 24-O-(beta-D-glucuronate) + UDP (RHEA:52956)
catalytic activity: hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta- D-glucuronate) + UDP (RHEA:52960)
catalytic activity: calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D- glucuronide) + H(+) + UDP (RHEA:55840)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta- D-glucuronide + UDP (RHEA:63728)
catalytic activity: UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-2-N- beta-D-glucuronide (RHEA:63748)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).

Q20CK9 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.6 bits

Q20CL6 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 324:459 / 533 (25.5%), covers 73.8% of PF06722, 57.6 bits

UGT1A4 / P22310 UDP-glucuronosyltransferase 1-4 (EC 2.4.1.17) from Homo sapiens (see 6 papers)
UD14_HUMAN / P22310 UDP-glucuronosyltransferase 1A4; UGT1A4; Bilirubin-specific UDPGT isozyme 2; hUG-BR2; UDP-glucuronosyltransferase 1-4; UDPGT 1-4; UGT1*4; UGT1-04; UGT1.4; UDP-glucuronosyltransferase 1-D; UGT-1D; UGT1D; EC 2.4.1.17 from Homo sapiens (Human) (see 8 papers)
P22310 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 27 papers)
Aligns to 323:460 / 534 (25.8%), covers 73.8% of PF06722, 57.6 bits

function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842).
function: [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D- glucuronide) + H(+) + UDP (RHEA:55840)
catalytic activity: calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D- glucuronide) + H(+) + UDP (RHEA:55844)
catalytic activity: calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta- D-glucuronide) + H(+) + UDP (RHEA:55836)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).

Q9TSL7 glucuronosyltransferase (EC 2.4.1.17) from Macaca fascicularis (see 2 papers)
Aligns to 324:459 / 533 (25.5%), covers 73.8% of PF06722, 57.6 bits

Q20CL0 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.5 bits

UD2B4_HUMAN / P06133 UDP-glucuronosyltransferase 2B4; UDPGT 2B4; UGT2B4; HLUG25; Hyodeoxycholic acid-specific UDPGT; UDPGTh-1; EC 2.4.1.17 from Homo sapiens (Human) (see 3 papers)
P06133 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 8 papers)
Aligns to 321:459 / 528 (26.3%), covers 71.7% of PF06722, 57.5 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52872)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52916)

D2SMM4 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:459 / 528 (26.3%), covers 71.7% of PF06722, 57.5 bits

Q20CL2 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 325:460 / 534 (25.5%), covers 73.8% of PF06722, 57.5 bits

Q20CK8 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.5 bits

Q20CL3 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 325:460 / 534 (25.5%), covers 73.8% of PF06722, 57.4 bits

Q9TSM0 glucuronosyltransferase (EC 2.4.1.17) from Macaca fascicularis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.4 bits

Q20CL5 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 325:460 / 534 (25.5%), covers 73.8% of PF06722, 57.3 bits

UDB23_MACFA / Q9TSL6 UDP-glucuronosyltransferase 2B23; UDPGT 2B23; EC 2.4.1.17 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
Aligns to 321:458 / 529 (26.1%), covers 72.4% of PF06722, 57.3 bits

function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on 6 steroids and the bile acid, hyodeoxycholic acid. May potentially play an important role in estrogen and androgen catabolism in peripheral steroid target tissues
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

Q9TSL9 glucuronosyltransferase (EC 2.4.1.17) from Macaca fascicularis (see paper)
Aligns to 331:458 / 532 (24.1%), covers 73.8% of PF06722, 57.3 bits

UD3A2_MOUSE / Q8JZZ0 UDP-glucuronosyltransferase 3A2; UDPGT 3A2; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Aligns to 314:456 / 523 (27.3%), covers 82.8% of PF06722, 57.3 bits

function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

Q20CL1 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 331:458 / 532 (24.1%), covers 73.8% of PF06722, 57.2 bits

UDB28_HUMAN / Q9BY64 UDP-glucuronosyltransferase 2B28; UDPGT 2B28; UGT2B28; EC 2.4.1.17 from Homo sapiens (Human) (see paper)
Q9BY64 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see paper)
Aligns to 322:457 / 529 (25.7%), covers 68.3% of PF06722, 56.2 bits

function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:11300766). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:11300766). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (androsterone, 3alpha-androstanediol) and estrogens (estradiol, estrone) (PubMed:11300766). Catalyzes the glucuronidation of bile acid substrates, which are natural detergents for dietary lipids absorption (PubMed:11300766). Displays glucuronidation activity toward the phenolic compounds eugenol (PubMed:11300766).
function: [Isoform 2]: Lack UDP-glucuronosyltransferase (UGT) activity.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

D2SMM3 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 322:459 / 529 (26.1%), covers 71.7% of PF06722, 56.2 bits

D2SMM2 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:459 / 529 (26.3%), covers 71.7% of PF06722, 56.1 bits

UGT2B7 / P16662 UDP-glucuronosyltransferase 2B7 (EC 2.4.1.17) from Homo sapiens (see 2 papers)
UD2B7_HUMAN / P16662 UDP-glucuronosyltransferase 2B7; UDPGT 2B7; UGT2B7; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronosyltransferase 2B9; UDPGT 2B9; UDPGTh-2; EC 2.4.1.17 from Homo sapiens (Human) (see 13 papers)
P16662 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 39 papers)
Aligns to 312:459 / 529 (28.0%), covers 71.7% of PF06722, 55.9 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10702251, PubMed:15472229, PubMed:15470161, PubMed:18674515, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:23756265, PubMed:26220143, PubMed:17442341). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15470161, PubMed:18674515, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:2159463, PubMed:15472229, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:26220143, PubMed:17442341). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development (PubMed:10702251). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52872)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53040)
catalytic activity: 4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O- (beta-D-glucuronate) + H(+) + UDP (RHEA:53060)
catalytic activity: 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha- hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52452)
catalytic activity: 16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52472)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52920)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52916)
catalytic activity: epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52568)
catalytic activity: hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP (RHEA:52964)
catalytic activity: hyocholate + UDP-alpha-D-glucuronate = H(+) + hyocholate 6-O- (beta-D-glucuronate) + UDP (RHEA:52968)
catalytic activity: all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans- retinoyl-1-O-(beta-D-glucuronate) + UDP (RHEA:55768)
catalytic activity: all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = all- trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP (RHEA:55776)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O- acyl-beta-D-glucuronide + UDP (RHEA:63700)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta- D-glucuronide + UDP (RHEA:63728)
catalytic activity: UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan O- beta-D-glucuronoside (RHEA:63732)

D2SMM5 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 311:459 / 529 (28.2%), covers 71.7% of PF06722, 55.9 bits

UDB18_MACFA / O97951 UDP-glucuronosyltransferase 2B18; UDPGT 2B18; EC 2.4.1.17 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
Aligns to 321:459 / 529 (26.3%), covers 71.7% of PF06722, 55.7 bits

function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward 3-hydroxyandrogens. It is principally active on C19 steroids having a hydroxyl group at position 3-alpha of the steroid molecule and also active on planar phenols and bile acids
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

fscMI / Q6W5Q9 mycosamine glycosyltransferase from Streptomyces sp. FR-008 (see 3 papers)
Aligns to 320:441 / 458 (26.6%), covers 71.0% of PF06722, 55.4 bits

Q6K1J1 glucuronosyltransferase (EC 2.4.1.17) from Canis lupus familiaris (see paper)
Aligns to 313:459 / 530 (27.7%), covers 72.4% of PF06722, 55.3 bits

UD2A3_MOUSE / Q8BWQ1 UDP-glucuronosyltransferase 2A3; UDPGT 2A3; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Aligns to 316:459 / 534 (27.0%), covers 73.8% of PF06722, 55.0 bits

function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

UD2A2_HUMAN / P0DTE5 UDP-glucuronosyltransferase 2A2; UDPGT 2A2; EC 2.4.1.17 from Homo sapiens (Human) (see 4 papers)
Aligns to 325:466 / 536 (26.5%), covers 73.8% of PF06722, 55.0 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:19858781, PubMed:18719240, PubMed:23756265, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormone estradiol (PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP (RHEA:52940)
catalytic activity: lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52952)
catalytic activity: deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52948)
catalytic activity: hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta- D-glucuronate) + UDP (RHEA:52960)
catalytic activity: hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP (RHEA:52964)

ATG26_PICAN / A7KAK6 Sterol 3-beta-glucosyltransferase; Autophagy-related protein 26; EC 2.4.1.-; EC 2.4.1.173 from Pichia angusta (Yeast) (Hansenula polymorpha) (see paper)
A7KAK6 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Ogataea angusta (see paper)
Aligns to 1055:1195 / 1241 (11.4%), covers 65.5% of PF06722, 54.7 bits

function: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside (By similarity). Mediates autophagic degradation of peroxisomes (pexophagy) (PubMed:17204848).
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)
catalytic activity: ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D- glucoside + H(+) + UDP (RHEA:61836)

GTFC_AMYOR / P96560 Glycosyltransferase GtfC; EC 2.4.1.- from Amycolatopsis orientalis (Nocardia orientalis) (see 3 papers)
Aligns to 285:392 / 409 (26.4%), covers 62.1% of PF06722, 54.6 bits

function: Catalyzes the attachment of dTDP-L-4-epi-vancosamine to chloroorienticin B to form chloroeremomycin in the biosynthesis of glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics. Also able to use dTDP-L-4-epi-vancosamine and devancoaminyl-vancomycin (DVV) to create epivancomycin. Acts downstream of GtfA.
catalytic activity: devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + epivancomycin + H(+) (RHEA:45904)
catalytic activity: chloroorienticin B + dTDP-beta-L-vancosamine = chloroeremomycin + dTDP + H(+) (RHEA:45908)

UD2A1_HUMAN / P0DTE4 UDP-glucuronosyltransferase 2A1; UDPGT 2A1; UGT2A1; EC 2.4.1.17 from Homo sapiens (Human) (see 7 papers)
Aligns to 337:457 / 527 (23.0%), covers 73.1% of PF06722, 54.6 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10359671, PubMed:19858781, PubMed:18719240, PubMed:19022937, PubMed:23756265, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:10359671, PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol) (PubMed:18719240, PubMed:19858781, PubMed:19022937, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction (PubMed:10359671). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air- born chemical after birth (PubMed:19858781).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52920)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52872)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP (RHEA:52456)
catalytic activity: epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52568)
catalytic activity: lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl- 3-O-(beta-D-glucuronate) + UDP (RHEA:53028)
catalytic activity: lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52952)
catalytic activity: deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52948)
catalytic activity: hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl- 24-O-(beta-D-glucuronate) + UDP (RHEA:52956)
catalytic activity: hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta- D-glucuronate) + UDP (RHEA:52960)

D2SMM1 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 311:459 / 528 (28.2%), covers 71.0% of PF06722, 54.5 bits

UGT8 / Q16880 N-acylsphingosine galactosyltransferase/bile acid galactosyltransferase (EC 2.4.1.47) from Homo sapiens (see 12 papers)
CGT_HUMAN / Q16880 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase; EC 2.4.1.47 from Homo sapiens (Human) (see paper)
Q16880 N-acylsphingosine galactosyltransferase (EC 2.4.1.47) from Homo sapiens (see 2 papers)
Aligns to 306:445 / 541 (25.9%), covers 77.2% of PF06722, 54.3 bits

function: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed:9125199). Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity).
catalytic activity: an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D- galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP (RHEA:13093)
catalytic activity: an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D- galactosylceramide + H(+) + UDP (RHEA:48344)
catalytic activity: N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP (RHEA:43400)
catalytic activity: N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP (RHEA:43404)

GTFE_AMYOR / Q9AFC6 Glycosyltransferase GtfE; EC 2.4.1.- from Amycolatopsis orientalis (Nocardia orientalis) (see 2 papers)
Aligns to 286:391 / 409 (25.9%), covers 53.1% of PF06722, 54.2 bits

function: D-glucosyltransferase that acts on the aglycone core, transferring D-glucose to the phenolic hydroxyl of OH-Phegly(4) to form a devancoaminyl-vancomycin (DVV) intermediate in the biosynthesis of glycopeptide antibiotic vancomycin. Also able to glycosylate A47934, an antibiotic with a teicoplanin-like heptapeptide, but lacking sugar residues.

P36537 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 9 papers)
Aligns to 311:458 / 528 (28.0%), covers 72.4% of PF06722, 54.0 bits

O75310 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 3 papers)
Aligns to 322:459 / 529 (26.1%), covers 72.4% of PF06722, 54.0 bits

Q6UWM9 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 3 papers)
Aligns to 318:457 / 527 (26.6%), covers 73.8% of PF06722, 53.9 bits

Q3SY77 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 2 papers)
Aligns to 314:456 / 523 (27.3%), covers 81.4% of PF06722, 53.8 bits

D2SMM0 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 311:459 / 528 (28.2%), covers 71.0% of PF06722, 53.6 bits

A0A0G2JMZ5 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see paper)
Aligns to 125:263 / 332 (41.9%), covers 73.1% of PF06722, 53.5 bits

UD2B1_RAT / P09875 UDP-glucuronosyltransferase 2B1; UDPGT 2B1; UGT2B1; UDPGTr-2; EC 2.4.1.17 from Rattus norvegicus (Rat) (see paper)
P09875 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 2 papers)
Aligns to 323:460 / 529 (26.1%), covers 88.3% of PF06722, 53.2 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240). Catalyzes the glucuronidation of the endogenous estrogen hormone estradiol (PubMed:18719240).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)

U80B1_ARATH / Q9XIG1 Sterol 3-beta-glucosyltransferase UGT80B1; Protein TRANSPARENT TESTA 15; UDP-glucose:sterol glucosyltransferase 80B1; EC 2.4.1.173 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9XIG1 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Arabidopsis thaliana (see 3 papers)
Aligns to 448:560 / 615 (18.4%), covers 58.6% of PF06722, 52.9 bits

function: Involved in the biosynthesis of sterol glucosides. Catalyzes the synthesis of steryl glycosides (SGs) and acyl steryl glycosides (ASGs) which are the most abundant sterol derivatives in higher plants. Can act on several sterols like sitosterol, campesterol and stigmasterol. Is required for embryonic development, seed suberin accumulation, cutin formation and flavanoid accumulation in the seed coat. Both UGT80A2 and UGT80B1 are required for the normal production of SGs and ASGs in seeds.
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)
disruption phenotype: Reduced growth rates. Altered embryonic development, seed suberin accumulation, cutin formation in the seed coat and reduced seed size. Lack of flavanoid accumulation in the seed coat (transparent testa phenotype).

GTFB_AMYOR / P96559 Vancomycin aglycone glucosyltransferase; Glycosyltransferase GtfB; EC 2.4.1.310 from Amycolatopsis orientalis (Nocardia orientalis) (see 4 papers)
P96559 vancomycin aglycone glucosyltransferase (EC 2.4.1.310) from Amycolatopsis orientalis (see 2 papers)
Aligns to 284:391 / 407 (26.5%), covers 55.9% of PF06722, 52.8 bits

function: Glucosyltransferase that transfers glucose to the 4-OH- Phegly(4) residue of vancomycin aglycone (AGV) to produce devancoaminyl-vancomycin (DVV) in the biosynthesis of glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics.
catalytic activity: UDP-alpha-D-glucose + vancomycin aglycone = devancoaminyl- vancomycin + UDP (RHEA:38587)

ATG26_YEAST / Q06321 Sterol 3-beta-glucosyltransferase; Autophagy-related protein 26; UDP-glycosyltransferase 51; EC 2.4.1.-; EC 2.4.1.173 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
Q06321 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Saccharomyces cerevisiae (see 5 papers)
Aligns to 1031:1147 / 1198 (9.8%), covers 71.7% of PF06722, 52.4 bits

function: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside (PubMed:10224056, PubMed:30395931). Shows also activity in vitro on other sterols such as cholesterol, beta-sitosterol, stigmasterol and tomatidine (PubMed:10224056). In contrasts to what is observed in Pichia pastoris and Aspergillus oryzae, is not involved in cytoplasm to vacuole transport (Cvt), pexophagy or nonselective autophagy in Saccharomyces cerevisiae (PubMed:17012830).
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)
catalytic activity: ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D- glucoside + H(+) + UDP (RHEA:61836)

ATG26_CANAL / Q5A950 Sterol 3-beta-glucosyltransferase; Autophagy-related protein 26; UDP-glycosyltransferase 51; EC 2.4.1.-; EC 2.4.1.173 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
Q5A950 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Candida albicans (see paper)
Aligns to 1303:1421 / 1512 (7.9%), covers 70.3% of PF06722, 52.4 bits

function: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)
catalytic activity: ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D- glucoside + H(+) + UDP (RHEA:61836)

ATG26_KOMPG / Q9Y751 Sterol 3-beta-glucosyltransferase; Autophagy-related protein 26; Peroxisome degradation protein 3; Pexophagy zeocin-resistant mutant protein 4; UDP-glycosyltransferase 51; EC 2.4.1.-; EC 2.4.1.173 from Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) (see 5 papers)
Q9Y751 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Komagataella pastoris (see 3 papers)
Aligns to 1032:1167 / 1211 (11.2%), covers 71.7% of PF06722, 52.3 bits

function: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside (PubMed:10224056). Shows also activity in vitro on other sterols such as cholesterol, beta- sitosterol, stigmasterol and tomatidine (PubMed:10224056). Probable sterol 3-beta-glucosyltransferase that mediates autophagic degradation of peroxisomes (pexophagy) (PubMed:11856375, PubMed:12839986, PubMed:14585290, PubMed:19605559).
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)
catalytic activity: ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D- glucoside + H(+) + UDP (RHEA:61836)

tylN / O70023 O-mycaminosyltylonolide 6-deoxyallosyltransferase (EC 2.4.1.317) from Streptomyces fradiae (see paper)
TYLN_STRFR / O70023 O-mycaminosyltylonolide 6-deoxyallosyltransferase; EC 2.4.1.317 from Streptomyces fradiae (Streptomyces roseoflavus) (see paper)
O70023 O-mycaminosyltylonolide 6-deoxyallosyltransferase (EC 2.4.1.317) from Streptomyces fradiae (see paper)
Aligns to 293:407 / 422 (27.3%), covers 62.1% of PF06722, 52.2 bits

function: Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of 6-deoxy-alpha-D-allose from dTDP-6-deoxy-alpha-D-allose to O-mycaminosyltylonolide (OMT) to yield demethyllactenocin.
catalytic activity: 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = demethyllactenocin + dTDP + H(+) (RHEA:15357)
disruption phenotype: Cells lacking this gene produce demycinosyl- tylosin.

A0A4Y1KAF7 glucuronosyltransferase (EC 2.4.1.17) from Macaca fascicularis (see paper)
Aligns to 315:459 / 527 (27.5%), covers 69.0% of PF06722, 52.1 bits

A0A4Y1K7J9 glucuronosyltransferase (EC 2.4.1.17) from Macaca fascicularis (see paper)
Aligns to 324:468 / 536 (27.1%), covers 69.0% of PF06722, 52.1 bits

UDB15_HUMAN / P54855 UDP-glucuronosyltransferase 2B15; UDPGT 2B15; UGT2B15; HLUG4; UDP-glucuronosyltransferase 2B8; UDPGT 2B8; UDPGTh-3; EC 2.4.1.17 from Homo sapiens (Human) (see 6 papers)
P54855 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 17 papers)
Aligns to 323:459 / 530 (25.8%), covers 73.1% of PF06722, 52.1 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7835232). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4- hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7835232). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52924)
catalytic activity: 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D- glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53000)

Q8K154 glucuronosyltransferase (EC 2.4.1.17) from Mus musculus (see paper)
Aligns to 326:462 / 532 (25.8%), covers 73.1% of PF06722, 52.0 bits

gtfD / Q9AFC7 desvancosaminyl-vancomycin vancosaminetransferase (EC 2.4.1.322) from Amycolatopsis orientalis (see 2 papers)
GTFD_AMYOR / Q9AFC7 Devancosaminyl-vancomycin vancosaminetransferase; Devancosamine-vancomycin TDP-vancosaminyltransferase; Glycosyltransferase GtfD; EC 2.4.1.322 from Amycolatopsis orientalis (Nocardia orientalis) (see 2 papers)
Q9AFC7 devancosaminyl-vancomycin vancosaminetransferase (EC 2.4.1.322) from Amycolatopsis orientalis (see 5 papers)
Aligns to 281:391 / 408 (27.2%), covers 62.8% of PF06722, 51.8 bits

function: Catalyzes the attachment of L-vancosamine to a monoglucosylated heptapeptide intermediate during the final stage of glycopeptide antibiotic vancomycin biosynthesis.
catalytic activity: devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + H(+) + vancomycin (RHEA:39891)

CGT_RAT / Q09426 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; CGalT; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase; EC 2.4.1.47 from Rattus norvegicus (Rat) (see 2 papers)
Aligns to 306:442 / 541 (25.3%), covers 74.5% of PF06722, 51.7 bits

function: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (PubMed:8713090).
catalytic activity: an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D- galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP (RHEA:13093)
catalytic activity: N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP (RHEA:43400)
catalytic activity: N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP (RHEA:43404)
catalytic activity: an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D- galactosylceramide + H(+) + UDP (RHEA:48344)

Q6CUV2 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Kluyveromyces lactis (see paper)
Aligns to 1031:1149 / 1209 (9.8%), covers 70.3% of PF06722, 51.4 bits

UDB17_HUMAN / O75795 UDP-glucuronosyltransferase 2B17; UDPGT 2B17; UGT2B17; C19-steroid-specific UDP-glucuronosyltransferase; C19-steroid-specific UDPGT; EC 2.4.1.17 from Homo sapiens (Human) (see 6 papers)
O75795 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 12 papers)
Aligns to 323:459 / 530 (25.8%), covers 73.1% of PF06722, 51.2 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:8798464, PubMed:16595710, PubMed:18719240, PubMed:19022937, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol) (PubMed:8798464, PubMed:16595710, PubMed:18719240, PubMed:19022937, PubMed:23288867).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52872)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D- glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53000)
catalytic activity: testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP (RHEA:52456)

UD3A1_MOUSE / Q3UP75 UDP-glucuronosyltransferase 3A1; UDPGT 3A1; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Aligns to 314:457 / 523 (27.5%), covers 88.3% of PF06722, 51.1 bits

function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

UDB30_MACFA / Q8WN97 UDP-glucuronosyltransferase 2B30; UDPGT 2B30; EC 2.4.1.17 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
Aligns to 311:458 / 528 (28.0%), covers 71.0% of PF06722, 50.9 bits

function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on testosterone, dihydrotestosterone, 5-alpha-androstane-3-alpha,17-beta-diol, androsterone, oestradiol, tetrahydroaldosterone and tetrahydrocortisone. This enzyme is essential to inactivation of several steroids
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

Q3UEP4 glucuronosyltransferase (EC 2.4.1.17) from Mus musculus (see paper)
Aligns to 328:459 / 530 (24.9%), covers 73.1% of PF06722, 50.2 bits

XNC1_1223 / D3V9Q6 rhabduscin glycosyltransferase from Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / CCUG 14189 / LMG 1036 / NCIMB 9965 / AN6) (see 2 papers)
Aligns to 279:423 / 428 (33.9%), covers 73.1% of PF06722, 50.1 bits

UDB15_RAT / P36511 UDP-glucuronosyltransferase 2B15; UDPGT 2B15; UGT2B15; UDP-glucuronosyltransferase 2B36; UDPGT 2B36; EC 2.4.1.17 from Rattus norvegicus (Rat) (see paper)
P36511 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 2 papers)
Aligns to 326:460 / 530 (25.5%), covers 72.4% of PF06722, 50.1 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:7574722). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7574722). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:7574722). Displays glucuronidation activity toward several classes of xenoblotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4- hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7574722). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (PubMed:7574722).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52924)
catalytic activity: 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D- glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53000)

F4KII1 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Arabidopsis thaliana (see paper)
Aligns to 384:491 / 520 (20.8%), covers 62.8% of PF06722, 49.6 bits

GT1_BEAB2 / J4VV61 UDP-glucosyltransferase 1; GT1; EC 2.4.1.- from Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae) (see paper)
Aligns to 311:455 / 461 (31.5%), covers 86.9% of PF06722, 49.5 bits

function: UDP-glucosyltransferase; part of the pathway that mediates the biosynthesis of tenellin-type 2-pyridones, iron-chelating compounds involved in iron stress tolerance, competition with the natural competitor fungus Metarhizium robertsii and insect hosts infection (PubMed:34903054). Targets the N-OH hydroxyl residue of 15- hydroxytellenin (15-HT) to produce pyridovericin-N-O-(beta-D- glucopyranoside) which is further methylated by the methyltransferase MT1 to yield pyridovericin-N-O-(4-O-methyl-beta-D-glucopyranoside) (PMGP) (PubMed:34903054). The pathway begins with the assembly of the polyketide-amino acid backbone by the hybrid PKS-NRPS tenS with the help of the enoyl reductase tenC. These enzymes catalyze the synthesis of the pyrrolidine-2-dione intermediates pretellinin A, 11- hydropretellenin A, 12-hydropretellenin A, 13-hydropretellenin A, 14- hydropretellenin A, 12-oxopretellenin A and prototellinin D. The cytochrome P450 monooxygenase tenA then catalyzes an oxidative ring expansion of pretenellin A and 14-hydropretellenin A to form the 2- pyridone core, leading to pretenellin B and pyridovericin, respectively. The cytochrome P450 monooxygenase tenB is then required for the selective N-hydroxylation of the 2-pyridone nitrogen of yield tellinin and 15-hydroxytellenin (15-HT), respectively. The UDP- glucosyltransferase GT1 and the methyltransferase MT1, located outside the tenS gene cluster, contribute to the stepwise glycosylation and methylation of 15-HT to obtain the glycoside pyridovericin-N-O-(4-O- methyl-beta-D-glucopyranoside) (PMGP). Additional related compounds such as 1-O-methyl-15-HT, (8Z)-1-O-methyl-15-HT, and O-methyltenellin A are also produced but the enzymes involved in their biosynthesis have still to be determined (PubMed:34903054).
disruption phenotype: Impairs the production of detectable pyridovericin-N-O-(4-O-methyl-beta-D-glucopyranoside) (PMGP).

UGT2 / A0A291PQH4 kermesate C-glycosyltranferase from Dactylopius coccus (see 2 papers)
UGT2_DACCO / A0A291PQH4 UDP-glucosyltransferase 2; DcUGT2; EC 2.4.1.- from Dactylopius coccus (Cochineal) (see paper)
Aligns to 310:446 / 515 (26.6%), covers 75.2% of PF06722, 49.5 bits

function: Membrane-bound UDP-glucosyltransferase (UGT) which catalyzes the C-glucosylation of kermesate and flavokermesate to produce carminate and flavokermesate 7-C-beta-D-glucoside (dcll) respectively (PubMed:29215010). Carminate is used as a deterrent against insect predators (PubMed:29215010).
catalytic activity: kermesate + UDP-alpha-D-glucose = carminate + 2 H(+) + UDP (RHEA:63752)
catalytic activity: flavokermesate + UDP-alpha-D-glucose = flavokermesate 7-C- beta-D-glucoside + 2 H(+) + UDP (RHEA:63756)

D2SML9 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 323:459 / 530 (25.8%), covers 73.1% of PF06722, 49.4 bits

A0A023NFQ4 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Gossypium hirsutum (see paper)
Aligns to 489:607 / 660 (18.0%), covers 69.0% of PF06722, 49.1 bits

Q6BN88 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Debaryomyces hansenii (see paper)
Aligns to 1343:1457 / 1574 (7.3%), covers 72.4% of PF06722, 49.1 bits

Q8VCN3 glucuronosyltransferase (EC 2.4.1.17) from Mus musculus (see paper)
Aligns to 328:459 / 530 (24.9%), covers 73.1% of PF06722, 48.1 bits

K4BTE6 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Solanum lycopersicum (see paper)
Aligns to 476:583 / 643 (16.8%), covers 60.0% of PF06722, 48.1 bits

UDB37_RAT / P19488 UDP-glucuronosyltransferase 2B37; UDPGT 2B37; 17-beta-hydroxysteroid-specific UDPGT; UDP-glucuronosyltransferase R-21; UDPGTr-21; UDPGTr-5; EC 2.4.1.17 from Rattus norvegicus (Rat) (see paper)
Aligns to 328:459 / 530 (24.9%), covers 72.4% of PF06722, 47.8 bits

function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. About 30-fold less active than Ugt2b17 toward testosterone and dihydrotestosterone.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

UGT80A2 / Q9M8Z7 3β-hydroxy sterol glucosyltransferase (EC 2.4.1.173) from Arabidopsis thaliana (see 3 papers)
U80A2_ARATH / Q9M8Z7 Sterol 3-beta-glucosyltransferase UGT80A2; UDP-glucose:sterol glucosyltransferase 80A2; EC 2.4.1.173 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9M8Z7 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Arabidopsis thaliana (see 4 papers)
Aligns to 480:602 / 637 (19.3%), covers 71.0% of PF06722, 47.5 bits

function: Involved in the biosynthesis of sterol glucosides. Catalyzes the synthesis of steryl glycosides (SGs) and acyl steryl glycosides (ASGs) which are the most abundant sterol derivatives in higher plants. Can act on several sterols like sitosterol, campesterol and stigmasterol. Both UGT80A2 and UGT80B1 are required for the normal production of SGs and ASGs in seeds.
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)
disruption phenotype: Reduced growth rates.

SGTL1 / Q2I015 3β-hydroxy sterol glucosyltransferase (EC 2.4.1.173) from Withania somnifera (see 4 papers)
Aligns to 538:647 / 701 (15.7%), covers 60.0% of PF06722, 47.2 bits

A5DNB9 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Meyerozyma guilliermondii (see paper)
Aligns to 1379:1492 / 1599 (7.1%), covers 65.5% of PF06722, 47.0 bits

UDB17_RAT / P08542 UDP-glucuronosyltransferase 2B17; UDPGT 2B17; UGT2B17; 17-beta-hydroxysteroid-specific UDPGT; RLUG38; Testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT; UDP-glucuronosyltransferase 2B5; UDPGT 2B5; UDPGTr-3; EC 2.4.1.17 from Rattus norvegicus (Rat) (see 2 papers)
P08542 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see paper)
Aligns to 326:460 / 530 (25.5%), covers 73.1% of PF06722, 46.1 bits

function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol) (PubMed:18719240) (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52872)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D- glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53000)
catalytic activity: testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP (RHEA:52456)

K4BS77 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Solanum lycopersicum (see paper)
Aligns to 456:574 / 608 (19.6%), covers 69.7% of PF06722, 45.7 bits

K4C3H8 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Solanum lycopersicum (see paper)
Aligns to 474:594 / 627 (19.3%), covers 71.7% of PF06722, 45.5 bits

nysDI / Q9L4W6 mycosaminyltranferase from Streptomyces noursei (see paper)
Aligns to 347:486 / 506 (27.7%), covers 71.7% of PF06722, 44.8 bits

Q62789 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see paper)
Aligns to 323:459 / 530 (25.8%), covers 68.3% of PF06722, 43.4 bits

UD2B2_RAT / P08541 UDP-glucuronosyltransferase 2B2; UDPGT 2B2; 3-hydroxyandrogen-specific UDPGT; RLUG23; UDPGTr-4; EC 2.4.1.17 from Rattus norvegicus (Rat) (see paper)
P08541 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see paper)
Aligns to 328:459 / 530 (24.9%), covers 69.0% of PF06722, 42.8 bits

function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B2 acts on various endogenous steroids, especially etiocholanolone and androsterone
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)

O22678 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Avena sativa (see 2 papers)
Aligns to 452:571 / 608 (19.7%), covers 73.1% of PF06722, 42.7 bits

A0A2D1N4Z8 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Solanum lycopersicum (see paper)
Aligns to 448:568 / 601 (20.1%), covers 71.0% of PF06722, 42.4 bits

A0A023NGA8 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Gossypium hirsutum (see paper)
Aligns to 474:594 / 625 (19.4%), covers 71.7% of PF06722, 42.3 bits

GTFA_AMYOR / P96558 dTDP-epi-vancosaminyltransferase; Glycosyltransferase AH1; GtfAH1; Glycosyltransferase GtfA; EC 2.4.1.311 from Amycolatopsis orientalis (Nocardia orientalis) (see 4 papers)
P96558 chloroorienticin B synthase (EC 2.4.1.311) from Amycolatopsis orientalis (see 2 papers)
Aligns to 264:382 / 396 (30.1%), covers 66.9% of PF06722, 41.9 bits

function: Catalyzes the attachment of 4-epi-vancosamine from a TDP donor to the beta-OH-Tyr-6 of the aglycone cosubstrate in the biosynthesis of glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics. Strongly prefers devancoaminyl- vancomycin (DVV) as substrate rather than the heptapeptide vancomycin aglycone (AGV). Acts downstream of GtfB.
catalytic activity: devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine = chloroorienticin B + dTDP + H(+) (RHEA:38591)

mycD / Q83WF1 mycinamicin VII 6-deoxyallosyltransferase from Micromonospora griseorubida (see 2 papers)
Aligns to 283:405 / 420 (29.3%), covers 60.7% of PF06722, 40.1 bits

UGT5_DACCO / A0A291PQF1 UDP-glycosyltransferase UGT5; UDP-glucosyltransferase 5; DcUGT5; EC 2.4.1.- from Dactylopius coccus (Cochineal) (see paper)
Aligns to 327:467 / 526 (26.8%), covers 71.7% of PF06722, 39.7 bits

function: Catalyzes the transfer of a glycosyl group from a UDP-sugar to an acceptor molecule.

FLRT_CITMA / Q8GVE3 Flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase; 1,2 rhamnosyltransferase; EC 2.4.1.236 from Citrus maxima (Pomelo) (Citrus grandis) (see 2 papers)
Q8GVE3 flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase (EC 2.4.1.236) from Citrus maxima (see paper)
Aligns to 303:430 / 452 (28.3%), covers 76.6% of PF06722, 38.1 bits

function: Involved in the production of the bitter neohesperidosides in citrus. Shows a strict specificity for UDP-rhamnose as donor.
catalytic activity: flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose = flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP (RHEA:15473)
subunit: Monomer.

UGAT / Q5NTH0 cyanidin-3-O-glucoside 2-O-glucuronosyltransferase (EC 2.4.1.254) from Bellis perennis (see paper)
UGAT_BELPE / Q5NTH0 Cyanidin-3-O-glucoside 2-O-glucuronosyltransferase; BpUGAT; UDP-glucuronic acid:anthocyanin glucuronosyltransferase; EC 2.4.1.254 from Bellis perennis (Daisy) (see 2 papers)
Q5NTH0 cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase (EC 2.4.1.254) from Bellis perennis (see paper)
Aligns to 304:429 / 438 (28.8%), covers 64.8% of PF06722, 38.0 bits

function: Involved in the production of glucuronosylated anthocyanins that are the origin of the red coloration of flowers. Can use cyanidin 3-O-6''-O-malonylglucoside, cyanidin 3-O-glucoside and delphinidin 3-O- glucosideas substrates, but not pelargonidin 3-O-glucoside, cyanidin 3- O-3'',6''-O-dimalonylglucoside, pelargonidin 3,5-O-diglucoside, pelargonidin 3-O-6''-O-malonylglucoside-5-O-glucoside, quercetin 3-O- glucoside, quercetin 3-O-6''-O-malonylglucoside, daidzin, genistin,7-O- 6''-O-malonylglucosides of daidzein and genistein, cyanidin, quercetin, daidzein, genistein p-Nitrophenyl beta-D-glucopyranoside, beta- estradiol, 17alpha-estradiol, 1-naphthol, 2-naphthol, 4- methylumbelliferone, and p-nitrophenol. Highly specific for UDP- glucuronate (UDP-GlcUA). Arg-25 is decisive with respect to UDP-sugar specificity.
catalytic activity: cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate = cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP (RHEA:28258)
subunit: Monomer.

EGT_NPVAC / P18569 Ecdysteroid UDP-glucosyltransferase; EC 2.4.1.- from Autographa californica nuclear polyhedrosis virus (AcMNPV) (see paper)
Aligns to 312:448 / 506 (27.1%), covers 81.4% of PF06722, 37.8 bits

function: Catalyzes the transfer of glucose from UDP-glucose to ecdysteroids which are insect molting hormones. Acts on the host at the organismal level to block its development, thereby increasing the yield of progeny virus.

ATG26_GLOLA / C4B4E5 Sterol 3-beta-glucosyltransferase; Autophagy-related protein 26; EC 2.4.1.-; EC 2.4.1.173 from Glomerella lagenarium (Anthracnose fungus) (Colletotrichum lagenarium) (see paper)
Aligns to 1271:1377 / 1475 (7.3%), covers 49.0% of PF06722, 36.7 bits

function: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside (By similarity). Mediates autophagic degradation of peroxisomes (pexophagy) and is involved in pathogenesis via peroxisome degradation inside appressoria that are developing into the host invasion stage (PubMed:19363139).
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)
catalytic activity: ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D- glucoside + H(+) + UDP (RHEA:61836)
disruption phenotype: Leads to delayed autophagic degradation of peroxisomes in the appressoria (PubMed:19363139).

Q0IG96 N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) from Aedes aegypti (see paper)
Aligns to 325:454 / 524 (24.8%), covers 67.6% of PF06722, 36.4 bits

FPY2_FUSMA / A0A1L7U2E9 UDP-glycosyltransferase FPY2; Fusapyrone biosynthesis cluster protein 2; EC 2.4.1.- from Fusarium mangiferae (Mango malformation disease fungus)
Aligns to 324:448 / 546 (22.9%), covers 63.4% of PF06722, 35.9 bits

function: UDP-glycosyltransferase; part of the gene cluster that mediates the biosynthesis of the gamma-pyrones fusapyrone (FPY) and deoxyfusapyrone (dFPY) (Ref.2). FPY is an undecaketide and thus likely synthesized by the polyketide synthase FPY1 from acetyl-CoA functioning as starter unit and the addition of 10 malonyl-CoA extender units by successive Claisen-condensations. Next to this, FPY shares some rare features: C-glycosylated 4-deoxyglucose at C-3, a gem-dimethyl group at C-13, and an alpha-beta to beta-gamma double bond shift at C-20. During FPY biosynthesis mono-C-methyl groups are transferred to the tetra-, penta-, hexa- and heptaketide, while two C-methyl groups are transferred to the nonaketide, suggesting that the CMet domain is programmed to selectively catalyze two successive C-alpha-methylation reactions of the nonaketide, while other alpha-carbons are non- or mono-methylated only. While the origin of the 4'-deoxyglucose moiety remains opaque, its transfer to C-3 is most likely mediated by the C- glycosyltransferase FPY2. Next to this, the hydroxyl group present at C-33 and discriminating between FPY and dFPY, is likely to be installed by the cytochrome P450 monooxygenase FPY7. No putative function can be predicted for the remaining genes FPY3-FPY6 (Probable).

UGT94E5 / F8WKW8 crocetin glucosyl ester glucosyltransferase (EC 2.4.1.330) from Gardenia jasminoides (see paper)
UGT9_GARJA / F8WKW8 Beta-D-glucosyl crocetin beta-1,6-glucosyltransferase; UDP-glucose glucosyltransferase 9; GjUGT9; UDP-glycosyltransferase 94E5; EC 2.4.1.330 from Gardenia jasminoides (Cape jasmine) (Gardenia augusta) (see paper)
F8WKW8 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase (EC 2.4.1.330) from Gardenia jasminoides (see 2 papers)
Aligns to 299:435 / 444 (30.9%), covers 55.9% of PF06722, 35.5 bits

function: Glucosyltransferase catalyzing the beta 1-6 glucosylation of the sugar moiety of crocetin glucosyl esters to produce crocetin gentiobiosyl esters. Weak activity toward curcumin glucosides, but no activity with flavonoid glucosides, coumarin glucosides, 4-nitrophenyl glucoside or crocetin. Involved with UGT75L6 in sequential glycosylation of crocetin to crocin (bis(beta-D-gentiobiosyl) crocetin).
catalytic activity: beta-D-glucosyl crocetin + UDP-alpha-D-glucose = beta-D- gentiobiosyl crocetin + H(+) + UDP (RHEA:42388)
catalytic activity: bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose = beta-D- gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP (RHEA:30899)
catalytic activity: beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D- glucose = bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP (RHEA:38859)

ATG26_GIBZE / I1S8Q3 Sterol 3-beta-glucosyltransferase ATG26; Autophagy-related protein 26; EC 2.4.1.-; EC 2.4.1.173 from Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) (see paper)
Aligns to 1245:1356 / 1443 (7.8%), covers 50.3% of PF06722, 34.8 bits

function: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)
catalytic activity: ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D- glucoside + H(+) + UDP (RHEA:61836)
disruption phenotype: Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).

ATG26_ASPOR / Q2U0C3 Sterol 3-beta-glucosyltransferase; Autophagy-related protein 26; EC 2.4.1.-; EC 2.4.1.173 from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) (see paper)
Aligns to 1185:1295 / 1384 (8.0%), covers 48.3% of PF06722, 34.7 bits

function: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside (By similarity). Involved in cytoplasm to vacuole transport (Cvt), pexophagy or nonselective autophagy (PubMed:27696999).
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)
catalytic activity: ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D- glucoside + H(+) + UDP (RHEA:61836)
disruption phenotype: Leads to white colonies with decreased conidiation and aerial hyphae formation (PubMed:27696999). Impairs autophagy by the accumulation of the intermediate of autophagosome (PubMed:27696999).

CGT_MANIN / A0A0M4KE44 UDP-glycosyltransferase 13; MiUGT13; C-glycosyltransferase; MiCGT; EC 2.4.1.- from Mangifera indica (Mango) (see paper)
Aligns to 322:447 / 470 (26.8%), covers 56.6% of PF06722, 34.1 bits

function: Benzophenone C-glycosyltransferase involved in the biosynthesis of mangiferin. Exhibits a robust regio- and stereospecific C-glycosylation activity toward over 35 substrates from 18 structurally different types with UDP-glucose. Also able to produce O- and N- glycosides and to use UDP-xylose as sugar donor. Generates only C- glycosides with 2,4,6-tri-hydroxy acceptors at the A ring, both C- and O- glycosides with 2,4-di-hydroxyl acceptors at the A ring, and only O- glycosides with 2- or 4-mono-hydroxy acceptors at the A ring.

GAME18 / A0A3Q7H9X4 γ-tomatine glucosyltransferase from Solanum lycopersicum (see paper)
Aligns to 298:422 / 441 (28.3%), covers 60.0% of PF06722, 33.0 bits

708G2_CITUN / A0A224AKZ9 UDP-glycosyltransferase 708G2; 2-hydroxyflavanone C-glucosyltransferase; CuCGT; EC 2.4.1.360 from Citrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu) (see paper)
Aligns to 326:447 / 472 (25.8%), covers 63.4% of PF06722, 32.9 bits

function: UDP-glucose-dependent glucosyltransferase catalyzing the C- glucosylation of 2-hydroxyflavanones (2-hydroxylnaringenin and 2- hydroxypinocembrin) and phloretin (PubMed:28370711). No activity with flavanones, flavones or flavonols (PubMed:28370711). Exhibits C- glucosylation activity toward 2-phenyl-2',4',6'-trihydroxyacetophenone (PubMed:28370711). Can use UDP-xylose as sugar donor, but catalytic efficiency is much lower toward UDP-xylose than toward UDP-glucose (PubMed:28370711).
catalytic activity: a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D- glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta- oxodihydrochalcone + H(+) + UDP (RHEA:51504)

UGT52_DICDI / Q54IL5 UDP-sugar-dependent glycosyltransferase 52; Sterol 3-beta-glucosyltransferase; UDP-glycosyltransferase 52; EC 2.4.1.173 from Dictyostelium discoideum (Social amoeba) (see paper)
Q54IL5 sterol 3beta-glucosyltransferase (EC 2.4.1.173) from Dictyostelium discoideum (see paper)
Aligns to 1501:1595 / 1697 (5.6%), covers 55.9% of PF06722, 32.9 bits

function: Involved in the biosynthesis of sterol glucoside. Can use different sterols such as cholesterol, sitosterol, and ergosterol as sugar acceptors.
catalytic activity: a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP (RHEA:22724)

Or search for genetic data about PF06722 in the Fitness Browser

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory