Family Search for PF07869 (DUF1656)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF07869 hits 21 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

RR42_RS03030 required for 4-hydroxybenzoate transport, together with NodT, MFP, and FUSC proteins (RR42_RS03040, RR42_RS03035, and RR42_RS03025) from Cupriavidus basilensis FW507-4G11
Aligns to 4:59 / 69 (81.2%), covers 100.0% of PF07869, 83.6 bits

• mutant phenotype: PFam PF07869.8 (DUF1656). Specifically important for utilization of 4-hydroxybenzoate (at 20 mM). Not clear if this system is for uptake or for efflux (as this compound is likely to be toxic at 20 mM)

PS417_00715 required for octanoate transport, together with NodT, MFP, and FUSC proteins (PS417_00725, PS417_00720, PS417_00710) from Pseudomonas simiae WCS417
Aligns to 4:59 / 69 (81.2%), covers 100.0% of PF07869, 75.5 bits

• mutant phenotype: PFam PF07869.8 (DUF1656). A conserved cofit operon. This and orthologous operons are important for growth in 20 mM octanoate (as the carbon source), which is probably toxic. This operon could also be for uptake rather than efflux.

PfGW456L13_506 required for octanoate transport, together with NodT, MFP, and FUSC proteins (PfGW456L13_504, PfGW456L13_505, PfGW456L13_507) from Pseudomonas fluorescens GW456-L13
Aligns to 4:59 / 69 (81.2%), covers 100.0% of PF07869, 74.8 bits

• mutant phenotype: PFam PF07869.8 (DUF1656). A conserved cofit operon. This and orthologous operons are important for utilization of octanoate, which is probably toxic at 20 mM, but it could also be for uptake rather than efflux.

AaeX / b3242 DUF1656 domain-containing protein AaeX from Escherichia coli K-12 substr. MG1655 (see 2 papers)
AAEX_ECOLI / P46478 Protein AaeX from Escherichia coli (strain K12) (see paper)
Aligns to 6:61 / 67 (83.6%), covers 98.2% of PF07869, 71.9 bits

AO353_04830 required for acetate efflux, together with NodT, MFP and FUSC proteins (AO353_04840, AO353_04825, and AO353_04835) from Pseudomonas fluorescens FW300-N2E3
Aligns to 4:59 / 66 (84.8%), covers 100.0% of PF07869, 71.7 bits

• mutant phenotype: PFam PF07869.8 (DUF1656). A conserved cofit operon. This operon and orthologous operons are important on acetate as a carbon source and cholin acetate as a stress, which suggests that acetate is a substrate.

AO356_17240 required for acetate efflux, together with NodT, MFP and FUSC proteins (AO356_17230, AO356_17245, and AO356_17235) from Pseudomonas fluorescens FW300-N2C3
Pf6N2E2_5373 required for cephalothin efflux, together with NodT, MFP and FUSC proteins (Pf6N2E2_5371, Pf6N2E2_5374, Pf6N2E2_5372) from Pseudomonas fluorescens FW300-N2E2
Aligns to 4:59 / 66 (84.8%), covers 100.0% of PF07869, 71.6 bits

• mutant phenotype: PFam PF07869.8 (DUF1656). A conserved cofit operon. This operon and orthologous operons are important on acetate as a carbon source and cholin acetate as a stress, which suggests that acetate is a substrate.
• mutant phenotype: PFam PF07869.8 (DUF1656). A conserved cofit operon. Specifically important for resisting cephalothin.

Pf6N2E2_2878 required for 4-hydroxybenzoate and octanoate transport, together with MFP and FUSC proteins (Pf6N2E2_2877, Pf6N2E2_2879) from Pseudomonas fluorescens FW300-N2E2
Aligns to 5:60 / 68 (82.4%), covers 98.2% of PF07869, 64.6 bits

• mutant phenotype: PFam PF07869.8 (DUF1656). A conserved cofit operon. Important for utilization of octanoate and 4-hydroxybenzoate, which are probably toxic at the high concentrations used (5-20 mM), but it could also be for uptake rather than efflux.

YdhI / b1643 DUF1656 domain-containing protein YdhI from Escherichia coli K-12 substr. MG1655 (see paper)
Aligns to 16:70 / 78 (70.5%), covers 92.9% of PF07869, 52.7 bits

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