Family Search for PF08933 (PrnB)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF08933 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

prnB / P95481 monodechloroaminopyrrolnitrin synthase from Pseudomonas fluorescens (see 2 papers)
PRNB_PSEFL / P95481 Monodechloroaminopyrrolnitrin synthase PrnB; 7-chloro-L-tryptophan dioxygenase PrnB; EC 1.14.19.- from Pseudomonas fluorescens (see 4 papers)
Aligns to 14:360 / 361 (96.1%), covers 96.1% of PF08933, 368.5 bits

• function: Involved in the biosynthesis of the antifungal antibiotic pyrrolnitrin. Catalyzes the ring rearrangement and decarboxylation to convert 7-chloro-L-tryptophan (7-CLT) to monodechloroaminopyrrolnitrin (MDA). It can also use 7-chloro-D-tryptophan, but 7-chloro-L-tryptophan is the preferred natural enantiomer.
  catalytic activity: 7-chloro-L-tryptophan + AH2 + O2 = A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin (RHEA:50952)
  cofactor: heme b
  subunit: Monomer.
  disruption phenotype: Cells lacking this gene lose the ability to produce pyrrolnitrin.

Or search for genetic data about PF08933 in the Fitness Browser