Family Search for PF10303 (DUF2408)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10303 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

CUB1_YEAST / Q08977 Cu(2+) suppressing and bleomycin sensitive protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
3 alignments in 209:525 / 551 (57.5%), covering up to 100.0% of PF10303, 211.6 bits

• function: Involved in bleomycin tolerance with links to DNA repair and/or proteasome function.
  subunit: Monomer.
  disruption phenotype: Leads to sensitivity to bleomycin (Ref.7). Bleomycin sensnsitivity is even increased when CUB1 deletion is combined with proteasome mutants including PRE9 or UMP1 disruptions (Ref.7). Suppresses the copper tolerance induced by the proteasome subunit PRE9 disuption (Ref.7). Leads to synthetic sickness with deletion of RAD6 on media containing bleomycin, but not hydroxyurea (HU) (Ref.7).

CUB1_SCHPO / Q9P6K3 CUB1 family protein C30C2.08 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
2 alignments in 172:453 / 457 (50.1%), covering up to 99.2% of PF10303, 179.3 bits

• function: Involved in bleomycin tolerance with links to DNA repair and/or proteasome function.

Or search for genetic data about PF10303 in the Fitness Browser