Family Search for PF11028 (DUF2723)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF11028 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TM260_HUMAN / Q9NX78 Protein O-mannosyl-transferase TMEM260; Transmembrane protein 260; EC 2.4.1.109 from Homo sapiens (Human) (see 3 papers)
Aligns to 52:215 / 707 (23.2%), covers 97.8% of PF11028, 136.9 bits

• function: O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins (PubMed:37186866). Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON (PubMed:37186866). TMEM260- mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified (PubMed:37186866).
  catalytic activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) (RHEA:17377)
  catalytic activity: a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) (RHEA:53396)

TM260_MOUSE / Q8BMD6 Protein O-mannosyl-transferase TMEM260; Transmembrane protein 260; EC 2.4.1.109 from Mus musculus (Mouse) (see paper)
Aligns to 48:211 / 703 (23.3%), covers 97.8% of PF11028, 132.6 bits

• function: O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins. Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON. TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.
  catalytic activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) (RHEA:17377)
  catalytic activity: a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) (RHEA:53396)
  disruption phenotype: Receptor maturation defects and abnormal epithelial morphogenesis.

Or search for genetic data about PF11028 in the Fitness Browser