Family Search for PF12480 (GARIL_Rab2_bd)

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PF12480 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

GAR3_HUMAN / Q8TC56 Golgi-associated RAB2 interactor protein 3 from Homo sapiens (Human) (see 2 papers)
Aligns to 116:186 / 605 (11.7%), covers 98.6% of PF12480, 103.8 bits

• function: May be involved in RNA biogenesis.
  subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form) (By similarity). Interacts with FRG1 (PubMed:17103222).

GAR3_MOUSE / Q5STT6 Golgi-associated RAB2B interactor protein 3; Protein FAM71B from Mus musculus (Mouse) (see 2 papers)
Aligns to 123:192 / 665 (10.5%), covers 91.5% of PF12480, 100.5 bits

• function: May be involved in RNA biogenesis.
  subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form) (PubMed:18256213). Interacts with FRG1.

GAR1A_MOUSE / B2RXB0 Golgi-associated RAB2 interactor protein 1A from Mus musculus (Mouse) (see 2 papers)
Aligns to 107:175 / 297 (23.2%), covers 98.6% of PF12480, 92.3 bits

• function: RAB2B effector protein required for accurate acrosome formation and normal male fertility.
  subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form).
  disruption phenotype: Mutant male fertility is significantly impaired compared with that of the controls (PubMed:34714330). Spermatozoa from mutant mice showed abnormal head shapes with an abnormal acrosome morphology (PubMed:34714330).

GAR1B_MOUSE / Q3UZD7 Golgi-associated RAB2 interactor protein 1B; Golgi-associated RAB2 interactor-like 1; GARI-L1 from Mus musculus (Mouse) (see paper)
Aligns to 140:208 / 341 (20.2%), covers 98.6% of PF12480, 89.4 bits

• function: RAB2B effector protein required for accurate acrosome formation and normal male fertility (PubMed:34714330). In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation (PubMed:34714330).
  disruption phenotype: Mutant males are sterile (PubMed:34714330). Spermatozoa from mutant mice showed abnormal head shapes with an abnormal swollen acrosome morphology and impaired acrosome reaction (PubMed:34714330).

GAR4_HUMAN / Q8IYT1 Golgi-associated RAB2 interactor protein 4; Golgi-associated Rab2B interactor-like 4; GARI-L4; GARI-like 4 from Homo sapiens (Human) (see paper)
Aligns to 115:184 / 594 (11.8%), covers 97.2% of PF12480, 88.3 bits

• function: RAB2B effector protein required for the compacted Golgi morphology, probably through interaction with small GTPase RAB2B.
  subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form).

GAR2_MOUSE / D3YV92 Golgi-associated RAB2 interactor protein 2 from Mus musculus (Mouse) (see paper)
Aligns to 114:184 / 440 (16.1%), covers 98.6% of PF12480, 84.4 bits

• function: Seems to play a role in sperm motility.
  subunit: Interacts with CALM1.

GAR2_HUMAN / Q8N9W8 Golgi-associated RAB2 interactor protein 2 from Homo sapiens (Human) (see paper)
Aligns to 115:185 / 422 (16.8%), covers 97.2% of PF12480, 83.9 bits

• function: Seems to play a role in sperm motility.
  subunit: Interacts with CALM1.

GAR5A_MOUSE / A1L3C1 Golgi-associated RAB2 interactor protein 5A; Golgi-associated RAB2B interactor-like 5; GARIL5 from Mus musculus (Mouse) (see 2 papers)
Aligns to 93:160 / 212 (32.1%), covers 88.7% of PF12480, 60.2 bits

• function: RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis.
  subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form).

Or search for genetic data about PF12480 in the Fitness Browser