Family Search for PF13962 (PGG)

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PF13962 hits 43 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

ITN1_ARATH / Q9C7A2 Ankyrin repeat-containing protein ITN1; Protein INCREASED TOLERANCE TO NACL from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 412:519 / 590 (18.3%), covers 99.1% of PF13962, 98.9 bits

• function: Involved in salt stress tolerance. May act through abscisic acid (ABA) signaling pathways and promote reactive oxygen species (ROS) production.
  subunit: Interacts with REM19/RTV1.
  disruption phenotype: No visible phenotype under normal growth conditions, but mutant seedlings show increased salt-stress tolerance.

ACD6_ARATH / Q8LPS2 Protein ACCELERATED CELL DEATH 6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
Aligns to 484:597 / 670 (17.0%), covers 96.6% of PF13962, 94.9 bits

• function: Dose-dependent activator of the defense response against virulent pathogens, including bacteria, fungi and oomycetes, that acts in a positive feedback loop with the defense signal salicylic acid (SA) (PubMed:14507999, PubMed:20520716, PubMed:10488236, PubMed:16297071, PubMed:19144005). Regulates the salicylic acid (SA) signaling pathway leading to cell death and modulating cell fate (e.g. cell enlargement and/or cell division) (PubMed:14507999, PubMed:10488236, PubMed:11722764). In response to SA signaling, triggers the accumulation of FLS2 at the plasma membrane, thus priming defenses (PubMed:24923602). Involved in SA-dependent freezing signaling and tolerance (PubMed:19959255).
  subunit: Component of large complexes containing, at least, FLS2, HSP70 and ACD6 in endoplasmic reticulum, plasma membrane and soluble fraction. Associated with HSP70 proteins during endoplasmic reticulum- associated degradation (ERAD). Reduced complex levels upon benzothiazole (BTH) treatment.
  disruption phenotype: Reduced responsiveness to benzothiazole (BTH) and upon P. syringae infection with reduced salicylic acid (SA) levels and increased disease susceptibility and attenuated defenses (PubMed:14507999). Increased sensitivity to biotrophic fungi (e.g. Golovinomyces orontii T1 and G. cichoracearum UCSC1), biotrophic oomycetes (e.g. Hyaloperonospora arabidopsidis Noco2) and hemi- biotrophic bacteria (e.g. Pseudomonas syringae pv. tomato DC3000) (PubMed:20520716).

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