Family Search for PF14780 (NEPRO_N)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF14780 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

NEPRO_MOUSE / Q8R2U2 Nucleolus and neural progenitor protein; Neural progenitor protein from Mus musculus (Mouse) (see 2 papers)
Aligns to 12:202 / 564 (33.9%), covers 99.5% of PF14780, 207.3 bits

• function: May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors (PubMed:19906856). May also play a role in preimplentation embryo development (PubMed:26178919).
  disruption phenotype: Knockout embryos die before preimplantation.

NEPRO_HUMAN / Q6NW34 Nucleolus and neural progenitor protein from Homo sapiens (Human) (see 3 papers)
Aligns to 12:202 / 567 (33.7%), covers 100.0% of PF14780, 192.9 bits

• function: May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.

Or search for genetic data about PF14780 in the Fitness Browser