Family Search for PF15021 (DUF4521)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF15021 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
SHLD1_HUMAN / Q8IYI0 Shieldin complex subunit 1; RINN1-REV7-interacting novel NHEJ regulator 3; Shield complex subunit 1 from Homo sapiens (Human) (see paper)
Aligns to 1:203 / 205 (99.0%), covers 100.0% of PF15021, 367.9 bits
- function: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
subunit: Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus.
Or search for genetic data about PF15021 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory