Family Search for PF15054 (DUF4535)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF15054 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

STMP1_DANRE / B3DFW5 Short transmembrane mitochondrial protein 1 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 4:44 / 46 (89.1%), covers 93.3% of PF15054, 42.1 bits

• function: Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (By similarity). Required for the formation of mitochondrial supercomplexes (SCs) (By similarity). Also required for the activation of the NLRP3 inflammasome (By similarity).
  disruption phenotype: Morpholino knockdown of the protein leads to various development defects, including smaller eye, abnormal head shape, malformations of the jaw, cardiac edema and a delayed yolk sac resorption (PubMed:23073385). Most animals die by 1 week of age (PubMed:23073385).

STMP1_HUMAN / E0CX11 Short transmembrane mitochondrial protein 1 from Homo sapiens (Human) (see 2 papers)
Aligns to 4:44 / 47 (87.2%), covers 97.8% of PF15054, 39.6 bits

• function: Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (PubMed:35450818). Required for the formation of mitochondrial supercomplexes (SCs) (PubMed:35450818). Also required for the activation of the NLRP3 inflammasome (By similarity).
  subunit: Interacts with components of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), such as UQCRC1/QCR1, UQCRC2/QCR2 and UQCR10/QCR9 (By similarity). Interacts with components of the cytochrome c oxidase (mitochondrial respiratory chain complex IV) complex, such as MT-CO2 (PubMed:35450818).

STMP1_MOUSE / P0DP99 Short transmembrane mitochondrial protein 1; Mitochondrial micropeptide-47; Mm47; Protein mitolamban from Mus musculus (Mouse) (see 2 papers)
Aligns to 4:44 / 47 (87.2%), covers 97.8% of PF15054, 39.6 bits

• function: Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (PubMed:35101990). Required for the formation of mitochondrial supercomplexes (SCs) (PubMed:35101990). Also required for the activation of the NLRP3 inflammasome (PubMed:31836654).
  subunit: Interacts with components of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), such as UQCRC1/QCR1, UQCRC2/QCR2 and UQCR10/QCR9 (PubMed:35101990). Interacts with components of the cytochrome c oxidase (mitochondrial respiratory chain complex IV) complex, such as MT-CO2 (By similarity).
  disruption phenotype: Mice were born at expected Mendelian ratios and do not show any visible phenotype, displaying normal heart function and cardiac dimensions (PubMed:35101990). Cells however display defects in complex III activity and metabolic perturbations in the heart, as well as altered complex III assembly into respiratory supercomplexes (PubMed:35101990).

S35U4_HUMAN / L0R6Q1 SLC35A4 upstream open reading frame protein from Homo sapiens (Human) (see paper)
Aligns to 64:100 / 103 (35.9%), covers 68.9% of PF15054, 37.1 bits

Or search for genetic data about PF15054 in the Fitness Browser