Family Search for PF16297 (DUF4939)
PF16297 hits 30 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
RTL8C_HUMAN / A6ZKI3 Retrotransposon Gag-like protein 8C; Mammalian retrotransposon derived protein 8C from Homo sapiens (Human) (see paper)
Aligns to 2:113 / 113 (99.1%), covers 100.0% of PF16297, 183.1 bits
LDOC1_HUMAN / O95751 Protein LDOC1; Leucine zipper protein down-regulated in cancer cells from Homo sapiens (Human) (see 2 papers)
Aligns to 24:138 / 146 (78.8%), covers 96.4% of PF16297, 182.9 bits
- function: May have an important role in the development and/or progression of some cancers
subunit: Interacts with NOD2.
RTL8A_HUMAN / Q9BWD3 Retrotransposon Gag-like protein 8A; Mammalian retrotransposon derived protein 8A from Homo sapiens (Human) (see paper)
Aligns to 2:113 / 113 (99.1%), covers 100.0% of PF16297, 181.7 bits
RTL8B_HUMAN / Q17RB0 Retrotransposon Gag-like protein 8B; Mammalian retrotransposon derived protein 8B from Homo sapiens (Human) (see paper)
Aligns to 2:113 / 113 (99.1%), covers 99.1% of PF16297, 181.7 bits
RTL6_HUMAN / Q6ICC9 Retrotransposon Gag-like protein 6; Leucine zipper protein down-regulated in cancer cells-like; Mammalian retrotransposon-derived protein 6; Protein LDOC1L from Homo sapiens (Human) (see paper)
Aligns to 84:179 / 239 (40.2%), covers 73.2% of PF16297, 73.6 bits
RTL6_MOUSE / Q505G4 Retrotransposon Gag-like protein 6; Mammalian retrotransposon-derived protein 6; Protein LDOC1L; Protein Sushi-15E3 from Mus musculus (Mouse) (see 2 papers)
Aligns to 83:179 / 243 (39.9%), covers 73.2% of PF16297, 72.2 bits
PEG10_HUMAN / Q86TG7 Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein from Homo sapiens (Human) (see 17 papers)
Aligns to 58:165 / 708 (15.3%), covers 74.1% of PF16297, 58.4 bits
- function: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).
subunit: Homooligomer; homooligomerizes into virion-like capsids (By similarity). Interacts with ACVRL1 (PubMed:15611116). Interacts with SIAH1 and SIAH2 (PubMed:12810624).
PEG10_MOUSE / Q7TN75 Retrotransposon-derived protein PEG10; MmPEG10; Embryonal carcinoma differentiation regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3; MyEF-3; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein from Mus musculus (Mouse) (see 10 papers)
Aligns to 130:220 / 958 (9.5%), covers 68.8% of PF16297, 51.7 bits
- function: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:30951545, PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (PubMed:16341224, PubMed:30951545). Involved at the immediate early stage of adipocyte differentiation (PubMed:17707377). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (By similarity). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (PubMed:9473521).
subunit: Homooligomer; homooligomerizes into virion-like capsids (PubMed:34413232). Interacts with ACVRL1 (By similarity). Interacts with SIAH1 and SIAH2 (By similarity).
disruption phenotype: Embryonic lethality resulting from placental defects.
RTL3_HUMAN / Q8N8U3 Retrotransposon Gag-like protein 3; Zinc finger CCHC domain-containing protein 5 from Homo sapiens (Human) (see paper)
Aligns to 219:325 / 475 (22.5%), covers 74.1% of PF16297, 50.1 bits
- function: May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.
RTL5_HUMAN / Q5HYW3 Retrotransposon Gag-like protein 5; Retrotransposon gag domain-containing protein 4 from Homo sapiens (Human) (see paper)
Aligns to 138:231 / 569 (16.5%), covers 67.9% of PF16297, 47.1 bits
RTL5_MOUSE / Q5DTT4 Retrotransposon Gag-like protein 5; Retrotransposon gag domain-containing protein 4 from Mus musculus (Mouse) (see paper)
Aligns to 141:237 / 599 (16.2%), covers 67.0% of PF16297, 45.3 bits
RTL1_MOUSE / Q7M732 Retrotransposon-like protein 1; Mammalian retrotransposon derived protein 1; Paternally expressed gene 11 protein; Retrotransposon-derived protein PEG11 from Mus musculus (Mouse) (see 3 papers)
Aligns to 434:538 / 1744 (6.0%), covers 72.3% of PF16297, 44.8 bits
- function: Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta.
disruption phenotype: Mice suffer from late fetal or neonatal lethality. Mice overexpressing Rtl1 show notable overgrowth and morphological abnormalities of the placenta.
BOP_HUMAN / Q7L3V2 Protein Bop; BH3-only protein; Retrotransposon Gag-like protein 10 from Homo sapiens (Human) (see paper)
Aligns to 85:183 / 364 (27.2%), covers 71.4% of PF16297, 40.5 bits
- function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.
subunit: Interacts (via BH3 domain) with VDAC1. Interacts with pro- survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK1.
RTL3_MOUSE / Q6P1Y1 Retrotransposon Gag-like protein 3; Zinc finger CCHC domain-containing protein 5 from Mus musculus (Mouse) (see 2 papers)
Aligns to 289:397 / 553 (19.7%), covers 80.4% of PF16297, 30.3 bits
- function: May function as a transcriptional regulator (Probable). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912).
Or search for genetic data about PF16297 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory