Family Search for PF16297 (DUF4939)

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PF16297 hits 31 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

RTL8C_HUMAN / A6ZKI3 Retrotransposon Gag-like protein 8C; Mammalian retrotransposon derived protein 8C from Homo sapiens (Human) (see paper)
Aligns to 2:113 / 113 (99.1%), covers 100.0% of PF16297, 183.1 bits

LDOC1_HUMAN / O95751 Protein LDOC1; Leucine zipper protein down-regulated in cancer cells from Homo sapiens (Human) (see 2 papers)
Aligns to 24:138 / 146 (78.8%), covers 96.4% of PF16297, 182.9 bits

• function: May have an important role in the development and/or progression of some cancers
  subunit: Interacts with NOD2.

RTL8A_HUMAN / Q9BWD3 Retrotransposon Gag-like protein 8A; Mammalian retrotransposon derived protein 8A from Homo sapiens (Human) (see paper)
Aligns to 2:113 / 113 (99.1%), covers 100.0% of PF16297, 181.7 bits

RTL8B_HUMAN / Q17RB0 Retrotransposon Gag-like protein 8B; Mammalian retrotransposon derived protein 8B from Homo sapiens (Human) (see paper)
Aligns to 2:113 / 113 (99.1%), covers 99.1% of PF16297, 181.7 bits

RTL6_HUMAN / Q6ICC9 Retrotransposon Gag-like protein 6; Leucine zipper protein down-regulated in cancer cells-like; Mammalian retrotransposon-derived protein 6; Protein LDOC1L from Homo sapiens (Human) (see paper)
Aligns to 84:179 / 239 (40.2%), covers 73.2% of PF16297, 73.6 bits

RTL6_MOUSE / Q505G4 Retrotransposon Gag-like protein 6; Mammalian retrotransposon-derived protein 6; Protein LDOC1L; Protein Sushi-15E3 from Mus musculus (Mouse) (see 2 papers)
Aligns to 83:179 / 243 (39.9%), covers 73.2% of PF16297, 72.2 bits

PEG10_HUMAN / Q86TG7 Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein from Homo sapiens (Human) (see 17 papers)
Aligns to 58:165 / 708 (15.3%), covers 74.1% of PF16297, 58.4 bits

• function: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).
  subunit: Homooligomer; homooligomerizes into virion-like capsids (By similarity). Interacts with ACVRL1 (PubMed:15611116). Interacts with SIAH1 and SIAH2 (PubMed:12810624).

PEG10_MOUSE / Q7TN75 Retrotransposon-derived protein PEG10; MmPEG10; Embryonal carcinoma differentiation regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3; MyEF-3; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein from Mus musculus (Mouse) (see 10 papers)
Aligns to 130:220 / 958 (9.5%), covers 68.8% of PF16297, 51.7 bits

• function: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:30951545, PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (PubMed:16341224, PubMed:30951545). Involved at the immediate early stage of adipocyte differentiation (PubMed:17707377). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (By similarity). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (PubMed:9473521).
  subunit: Homooligomer; homooligomerizes into virion-like capsids (PubMed:34413232). Interacts with ACVRL1 (By similarity). Interacts with SIAH1 and SIAH2 (By similarity).
  disruption phenotype: Embryonic lethality resulting from placental defects.

RTL3_HUMAN / Q8N8U3 Retrotransposon Gag-like protein 3; Zinc finger CCHC domain-containing protein 5 from Homo sapiens (Human) (see paper)
Aligns to 219:325 / 475 (22.5%), covers 74.1% of PF16297, 50.1 bits

• function: May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.

RTL5_HUMAN / Q5HYW3 Retrotransposon Gag-like protein 5; Retrotransposon gag domain-containing protein 4 from Homo sapiens (Human) (see paper)
Aligns to 138:231 / 569 (16.5%), covers 67.9% of PF16297, 47.1 bits

RTL5_MOUSE / Q5DTT4 Retrotransposon Gag-like protein 5; Retrotransposon gag domain-containing protein 4 from Mus musculus (Mouse) (see paper)
Aligns to 141:237 / 599 (16.2%), covers 67.0% of PF16297, 45.3 bits

RTL1_MOUSE / Q7M732 Retrotransposon-like protein 1; Mammalian retrotransposon derived protein 1; Paternally expressed gene 11 protein; Retrotransposon-derived protein PEG11 from Mus musculus (Mouse) (see 3 papers)
Aligns to 434:538 / 1744 (6.0%), covers 72.3% of PF16297, 44.8 bits

• function: Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta.
  disruption phenotype: Mice suffer from late fetal or neonatal lethality. Mice overexpressing Rtl1 show notable overgrowth and morphological abnormalities of the placenta.

BOP_HUMAN / Q7L3V2 Protein Bop; BH3-only protein; Retrotransposon Gag-like protein 10 from Homo sapiens (Human) (see paper)
Aligns to 85:183 / 364 (27.2%), covers 71.4% of PF16297, 40.5 bits

• function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.
  subunit: Interacts (via BH3 domain) with VDAC1. Interacts with pro- survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK1.

RTL3_MOUSE / Q6P1Y1 Retrotransposon Gag-like protein 3; Zinc finger CCHC domain-containing protein 5 from Mus musculus (Mouse) (see 2 papers)
Aligns to 289:397 / 553 (19.7%), covers 80.4% of PF16297, 30.3 bits

• function: May function as a transcriptional regulator (Probable). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912).

Or search for genetic data about PF16297 in the Fitness Browser