SitesBLAST
Comparing 3607861 FitnessBrowser__Dino:3607861 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
24% identity, 81% coverage: 7:511/621 of query aligns to 5:466/539 of 6lpiB
- active site: I27 (= I39), G29 (= G41), G30 (= G43), S31 (≠ N44), I32 (≠ V45), E53 (= E67), C76 (≠ S92), F115 (≠ L131), Q116 (= Q132), E117 (≠ Q133), K165 (≠ Q190), M256 (≠ V285), A283 (≠ T312), V375 (≠ A416), G401 (≠ S442), M403 (= M444), D428 (= D473), N455 (= N500), A457 (≠ G502), L458 (≠ F503), L460 (≠ V505), V461 (≠ I506), Q464 (≠ L509)
- binding flavin-adenine dinucleotide: R155 (vs. gap), G212 (= G239), G213 (= G240), G214 (= G241), T236 (= T265), L237 (≠ I266), M238 (≠ A267), L254 (≠ V283), M256 (≠ V285), H257 (≠ T286), G276 (= G305), A277 (≠ T306), R278 (= R307), D280 (≠ Q309), R282 (≠ F311), A283 (≠ T312), D300 (≠ N329), I301 (≠ A330), D319 (≠ A357), V320 (≠ L358), M380 (vs. gap), G398 (≠ F439)
- binding magnesium ion: D428 (= D473), N455 (= N500)
- binding thiamine diphosphate: E53 (= E67), C76 (≠ S92), P79 (= P95), G376 (= G417), Q377 (vs. gap), H378 (vs. gap), G401 (≠ S442), M403 (= M444), G427 (= G472), D428 (= D473), G429 (= G474), S430 (= S475), M433 (≠ L478), N455 (= N500), A457 (≠ G502), L458 (≠ F503), G459 (≠ A504), L460 (≠ V505), V461 (≠ I506)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
23% identity, 81% coverage: 56:561/621 of query aligns to 52:541/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ V285), R292 (≠ F311), W489 (≠ L509)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ A416), G401 (= G417), Q402 (vs. gap), H403 (vs. gap), G426 (≠ S442), M428 (= M444), G452 (= G472), D453 (= D473), G454 (= G474), S455 (= S475), L483 (≠ F503), G484 (≠ A504), M485 (≠ V505), V486 (≠ I506)
- binding flavin-adenine dinucleotide: R161 (≠ D177), G222 (= G239), G223 (= G240), G224 (= G241), T246 (= T265), L247 (≠ I266), M248 (≠ A267), M263 (≠ P282), L264 (≠ V283), M266 (≠ V285), H267 (≠ T286), G286 (= G305), R288 (= R307), V293 (≠ T312), D310 (≠ N329), I311 (≠ A330), D329 (= D346), V330 (≠ A347), M405 (≠ L419), G423 (= G433)
- binding magnesium ion: T82 (≠ S92), S83 (≠ A93), Q122 (= Q132), Y381 (= Y395), D453 (= D473), M458 (≠ L478), Q461 (≠ S481), N480 (= N500), H482 (≠ G502), K533 (≠ A553)
Sites not aligning to the query:
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
23% identity, 81% coverage: 56:561/621 of query aligns to 52:541/585 of 5k2oA
- active site: E59 (= E67), T82 (≠ S92), F121 (≠ H136), Q122 (≠ Y137), E123 (≠ G138), K171 (≠ Q190), M266 (≠ V285), V293 (≠ T312), V400 (≠ A416), G426 (≠ S442), M428 (= M444), D453 (= D473), N480 (= N500), H482 (≠ G502), L483 (≠ F503), M485 (≠ V505), V486 (≠ I506), W489 (≠ L509)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ V285), R292 (≠ F311), W489 (≠ L509)
- binding flavin-adenine dinucleotide: R161 (≠ D177), G222 (= G239), G223 (= G240), G224 (= G241), T246 (= T265), L247 (≠ I266), M248 (≠ A267), L264 (≠ V283), G286 (= G305), R288 (= R307), D290 (≠ Q309), V293 (≠ T312), D310 (≠ N329), I311 (≠ A330), D329 (= D346), V330 (≠ A347), Q404 (≠ G418), M405 (≠ L419), G423 (= G433)
- binding magnesium ion: D453 (= D473), N480 (= N500), H482 (≠ G502)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A416), G401 (= G417), Q402 (vs. gap), H403 (vs. gap), M428 (= M444), D453 (= D473), G454 (= G474), S455 (= S475), N480 (= N500), H482 (≠ G502), L483 (≠ F503), G484 (≠ A504), M485 (≠ V505), V486 (≠ I506)
Sites not aligning to the query:
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
23% identity, 81% coverage: 56:561/621 of query aligns to 52:541/583 of 5k3sA
- active site: E59 (= E67), T82 (≠ S92), F121 (≠ H136), Q122 (≠ Y137), E123 (≠ G138), K171 (≠ Q190), M266 (≠ V285), V293 (≠ T312), V400 (≠ A416), G426 (≠ S442), M428 (= M444), D453 (= D473), N480 (= N500), H482 (≠ G502), L483 (≠ F503), M485 (≠ V505), V486 (≠ I506), W489 (≠ L509)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (≠ F311), M485 (≠ V505), W489 (≠ L509)
- binding flavin-adenine dinucleotide: R161 (≠ D177), G222 (= G239), G223 (= G240), G224 (= G241), T246 (= T265), L247 (≠ I266), M248 (≠ A267), L264 (≠ V283), M266 (≠ V285), G286 (= G305), R288 (= R307), D290 (≠ Q309), V293 (≠ T312), D310 (≠ N329), I311 (≠ A330), D329 (= D346), V330 (≠ A347), M405 (≠ L419), G423 (= G433)
- binding magnesium ion: D453 (= D473), N480 (= N500), H482 (≠ G502)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A416), G401 (= G417), Q402 (vs. gap), H403 (vs. gap), G426 (≠ S442), M428 (= M444), D453 (= D473), G454 (= G474), S455 (= S475), N480 (= N500), H482 (≠ G502), L483 (≠ F503), G484 (≠ A504), M485 (≠ V505), V486 (≠ I506)
Sites not aligning to the query:
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
23% identity, 81% coverage: 56:561/621 of query aligns to 52:541/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ A416), G401 (= G417), Q402 (vs. gap), H403 (vs. gap), G426 (≠ S442), M428 (= M444), G452 (= G472), D453 (= D473), G454 (= G474), S455 (= S475), M458 (≠ L478), N480 (= N500), H482 (≠ G502), L483 (≠ F503), G484 (≠ A504), M485 (≠ V505), V486 (≠ I506)
- binding flavin-adenine dinucleotide: R161 (≠ D177), G222 (= G239), G223 (= G240), G224 (= G241), T246 (= T265), L247 (≠ I266), M248 (≠ A267), L264 (≠ V283), M266 (≠ V285), H267 (≠ T286), G286 (= G305), V287 (≠ T306), R288 (= R307), D290 (≠ Q309), R292 (≠ F311), V293 (≠ T312), D310 (≠ N329), I311 (≠ A330), D329 (= D346), V330 (≠ A347), M405 (≠ L419), G423 (= G433)
- binding magnesium ion: F370 (≠ D384), D453 (= D473), M458 (≠ L478), Q461 (≠ S481), N480 (= N500), H482 (≠ G502), K533 (≠ A553)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ V285), R292 (≠ F311), M485 (≠ V505), W489 (≠ L509)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
23% identity, 81% coverage: 56:561/621 of query aligns to 52:541/582 of 5wj1A
- active site: E59 (= E67), T82 (≠ S92), F121 (≠ H136), Q122 (≠ Y137), E123 (≠ G138), K171 (≠ Q190), M266 (≠ V285), V293 (≠ T312), V400 (≠ A416), G426 (≠ S442), M428 (= M444), D453 (= D473), N480 (= N500), H482 (≠ G502), L483 (≠ F503), M485 (≠ V505), V486 (≠ I506), W489 (≠ L509)
- binding flavin-adenine dinucleotide: R161 (≠ D177), G222 (= G239), G223 (= G240), G224 (= G241), T246 (= T265), L247 (≠ I266), M248 (≠ A267), M263 (≠ P282), L264 (≠ V283), G286 (= G305), R288 (= R307), V293 (≠ T312), D310 (≠ N329), I311 (≠ A330), D329 (= D346), V330 (≠ A347), M405 (≠ L419), G423 (= G433), G424 (= G440)
- binding magnesium ion: D453 (= D473), N480 (= N500), H482 (≠ G502)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ V285), D291 (= D310), R292 (≠ F311), M485 (≠ V505), W489 (≠ L509)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A416), G401 (= G417), Q402 (vs. gap), H403 (vs. gap), M428 (= M444), D453 (= D473), G454 (= G474), S455 (= S475), M458 (≠ L478), N480 (= N500), H482 (≠ G502), L483 (≠ F503), G484 (≠ A504), M485 (≠ V505), V486 (≠ I506)
Sites not aligning to the query:
- active site: 33, 35, 36, 37, 38, 558
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: 568
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
23% identity, 81% coverage: 56:561/621 of query aligns to 52:541/582 of 5k6tA
- active site: E59 (= E67), T82 (≠ S92), F121 (≠ H136), Q122 (≠ Y137), E123 (≠ G138), K171 (≠ Q190), M266 (≠ V285), V293 (≠ T312), V400 (≠ A416), G426 (≠ S442), M428 (= M444), D453 (= D473), N480 (= N500), H482 (≠ G502), L483 (≠ F503), M485 (≠ V505), V486 (≠ I506), W489 (≠ L509)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ T286), R292 (≠ F311), M485 (≠ V505), W489 (≠ L509)
- binding flavin-adenine dinucleotide: R161 (≠ D177), G222 (= G239), G223 (= G240), G224 (= G241), T246 (= T265), L247 (≠ I266), M248 (≠ A267), L264 (≠ V283), G286 (= G305), R288 (= R307), D290 (≠ Q309), R292 (≠ F311), V293 (≠ T312), D310 (≠ N329), I311 (≠ A330), D329 (= D346), V330 (≠ A347), Q404 (≠ G418), M405 (≠ L419), G423 (= G433)
- binding magnesium ion: D453 (= D473), N480 (= N500), H482 (≠ G502)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ A416), G401 (= G417), Q402 (vs. gap), H403 (vs. gap), G426 (≠ S442), M428 (= M444), G452 (= G472), G454 (= G474), S455 (= S475), N480 (= N500), H482 (≠ G502), L483 (≠ F503), G484 (≠ A504)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
23% identity, 81% coverage: 56:561/621 of query aligns to 52:541/582 of 5k6rA
- active site: E59 (= E67), T82 (≠ S92), F121 (≠ H136), Q122 (≠ Y137), E123 (≠ G138), K171 (≠ Q190), M266 (≠ V285), V293 (≠ T312), V400 (≠ A416), G426 (≠ S442), M428 (= M444), D453 (= D473), N480 (= N500), H482 (≠ G502), L483 (≠ F503), M485 (≠ V505), V486 (≠ I506), W489 (≠ L509)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (≠ F311), W489 (≠ L509)
- binding flavin-adenine dinucleotide: R161 (≠ D177), G222 (= G239), G223 (= G240), G224 (= G241), T246 (= T265), L247 (≠ I266), M248 (≠ A267), L264 (≠ V283), M266 (≠ V285), G286 (= G305), R288 (= R307), R292 (≠ F311), V293 (≠ T312), D310 (≠ N329), I311 (≠ A330), G328 (= G345), D329 (= D346), V330 (≠ A347), M405 (≠ L419), G423 (= G433)
- binding magnesium ion: D453 (= D473), N480 (= N500), H482 (≠ G502)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ A416), G401 (= G417), Q402 (vs. gap), H403 (vs. gap), G426 (≠ S442), M428 (= M444), D453 (= D473), G454 (= G474), S455 (= S475), M458 (≠ L478), N480 (= N500), H482 (≠ G502), L483 (≠ F503), G484 (≠ A504), M485 (≠ V505), V486 (≠ I506)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
23% identity, 81% coverage: 56:561/621 of query aligns to 52:541/582 of 1z8nA
- active site: E59 (= E67), T82 (≠ S92), F121 (≠ H136), Q122 (≠ Y137), E123 (≠ G138), K171 (≠ Q190), M266 (≠ V285), V293 (≠ T312), V400 (≠ A416), G426 (≠ S442), M428 (= M444), D453 (= D473), N480 (= N500), H482 (≠ G502), L483 (≠ F503), M485 (≠ V505), V486 (≠ I506), W489 (≠ L509)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (≠ R157), R161 (≠ D177), Y191 (≠ F204), R194 (≠ K207), D291 (= D310), R292 (≠ F311), D312 (≠ A331), W489 (≠ L509)
- binding flavin-adenine dinucleotide: R161 (≠ D177), G222 (= G239), G224 (= G241), T246 (= T265), L247 (≠ I266), M248 (≠ A267), L264 (≠ V283), G265 (= G284), M266 (≠ V285), H267 (≠ T286), G286 (= G305), V287 (≠ T306), R288 (= R307), D290 (≠ Q309), R292 (≠ F311), V293 (≠ T312), D310 (≠ N329), I311 (≠ A330), D329 (= D346), V330 (≠ A347), M405 (≠ L419), G423 (= G433), G424 (= G440)
- binding magnesium ion: D453 (= D473), N480 (= N500)
- binding thiamine diphosphate: V400 (≠ A416), G401 (= G417), Q402 (vs. gap), H403 (vs. gap), G426 (≠ S442), M428 (= M444), G452 (= G472), G454 (= G474), S455 (= S475), N480 (= N500), H482 (≠ G502), L483 (≠ F503), G484 (≠ A504), M485 (≠ V505), V486 (≠ I506)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
23% identity, 81% coverage: 56:561/621 of query aligns to 52:541/582 of 1yi1A
- active site: E59 (= E67), T82 (≠ S92), F121 (≠ H136), Q122 (≠ Y137), E123 (≠ G138), K171 (≠ Q190), M266 (≠ V285), V293 (≠ T312), V400 (≠ A416), G426 (≠ S442), M428 (= M444), D453 (= D473), N480 (= N500), H482 (≠ G502), L483 (≠ F503), M485 (≠ V505), V486 (≠ I506), W489 (≠ L509)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D310), R292 (≠ F311), W489 (≠ L509)
- binding flavin-adenine dinucleotide: R161 (≠ D177), G223 (= G240), G224 (= G241), T246 (= T265), L247 (≠ I266), M248 (≠ A267), M263 (≠ P282), L264 (≠ V283), G265 (= G284), M266 (≠ V285), H267 (≠ T286), G286 (= G305), V287 (≠ T306), R288 (= R307), D290 (≠ Q309), V293 (≠ T312), D310 (≠ N329), I311 (≠ A330), D329 (= D346), V330 (≠ A347), M405 (≠ L419), G423 (= G433), G424 (= G440)
- binding magnesium ion: D453 (= D473), N480 (= N500), H482 (≠ G502)
Sites not aligning to the query:
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 26:542/583 of 1t9bA
- active site: Y29 (≠ H42), G31 (vs. gap), G32 (= G43), A33 (≠ N44), I34 (≠ V45), E55 (= E67), T78 (= T90), F117 (≠ L131), Q118 (= Q132), E119 (≠ Q133), K167 (≠ Q190), R214 (≠ A249), M250 (≠ V285), V277 (≠ T312), V393 (≠ A416), L418 (≠ F441), G419 (≠ S442), M421 (= M444), D446 (= D473), N473 (= N500), E475 (≠ G502), Q476 (≠ F503), M478 (≠ V505), V479 (≠ I506), W482 (≠ L509), L504 (≠ H539), G509 (= G544), L510 (≠ A545)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ T121), P108 (≠ F122), F117 (≠ L131), D275 (= D310), R276 (≠ F311), M478 (≠ V505), W482 (≠ L509)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G203 (= G239), A204 (≠ G240), G205 (= G241), N208 (≠ Q243), T230 (= T265), L231 (≠ I266), Q232 (≠ A267), M247 (≠ P282), L248 (≠ V283), M250 (≠ V285), H251 (≠ T286), G270 (= G305), A271 (≠ T306), R272 (= R307), D274 (≠ Q309), R276 (≠ F311), V277 (≠ T312), E303 (≠ N329), V304 (≠ A330), N308 (≠ D334), D322 (= D346), A323 (= A347), Q397 (≠ P420), M398 (≠ A421), G416 (≠ F439), G417 (= G440)
- binding magnesium ion: D446 (= D473), N473 (= N500), E475 (≠ G502)
Sites not aligning to the query:
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 25:541/582 of 1t9dB
- active site: Y28 (≠ H42), G30 (vs. gap), G31 (= G43), A32 (≠ N44), I33 (≠ V45), E54 (= E67), T77 (= T90), F116 (≠ L131), Q117 (= Q132), E118 (≠ Q133), K166 (≠ Q190), R213 (≠ A249), M249 (≠ V285), V276 (≠ T312), V392 (≠ A416), L417 (≠ F441), G418 (≠ S442), M420 (= M444), D445 (= D473), N472 (= N500), E474 (≠ G502), Q475 (≠ F503), M477 (≠ V505), V478 (≠ I506), W481 (≠ L509), L503 (≠ H539), G508 (= G544), L509 (≠ A545)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G43), A32 (≠ N44), V106 (≠ T121), P107 (≠ F122), F116 (≠ L131), K166 (≠ Q190), M249 (≠ V285), D274 (= D310), R275 (≠ F311), W481 (≠ L509)
- binding flavin-adenine dinucleotide: R156 (vs. gap), G202 (= G239), A203 (≠ G240), G204 (= G241), N207 (≠ Q243), T229 (= T265), L230 (≠ I266), Q231 (≠ A267), L247 (≠ V283), M249 (≠ V285), H250 (≠ T286), G269 (= G305), A270 (≠ T306), R271 (= R307), D273 (≠ Q309), R275 (≠ F311), V276 (≠ T312), E302 (≠ N329), V303 (≠ A330), N307 (≠ D334), G320 (= G345), D321 (= D346), A322 (= A347), Q396 (≠ P420), M397 (≠ A421), G415 (≠ F439), G416 (= G440)
- binding magnesium ion: D445 (= D473), N472 (= N500), E474 (≠ G502)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E67), P80 (= P95), G418 (≠ S442), M420 (= M444), M450 (≠ L478)
Sites not aligning to the query:
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 26:554/595 of 1t9bB
- active site: Y29 (≠ H42), G31 (vs. gap), G32 (= G43), A33 (≠ N44), I34 (≠ V45), E55 (= E67), T78 (= T90), F117 (≠ L131), Q118 (= Q132), E119 (≠ Q133), K167 (≠ Q190), R226 (≠ A249), M262 (≠ V285), V289 (≠ T312), V405 (≠ A416), L430 (≠ F441), G431 (≠ S442), M433 (= M444), D458 (= D473), N485 (= N500), E487 (≠ G502), Q488 (≠ F503), M490 (≠ V505), V491 (≠ I506), W494 (≠ L509), L516 (≠ H539), G521 (= G544), L522 (≠ A545)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ T121), P108 (≠ F122), D287 (= D310), R288 (≠ F311), M490 (≠ V505), W494 (≠ L509)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G215 (= G239), A216 (≠ G240), G217 (= G241), N220 (≠ Q243), T242 (= T265), L243 (≠ I266), Q244 (≠ A267), M259 (≠ P282), L260 (≠ V283), M262 (≠ V285), H263 (≠ T286), G282 (= G305), A283 (≠ T306), R284 (= R307), D286 (≠ Q309), R288 (≠ F311), V289 (≠ T312), E315 (≠ N329), V316 (≠ A330), N320 (≠ D334), G333 (= G345), D334 (= D346), A335 (= A347), Q409 (≠ P420), M410 (≠ A421), G428 (≠ F439), G429 (= G440)
- binding magnesium ion: D458 (= D473), N485 (= N500), E487 (≠ G502)
Sites not aligning to the query:
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 26:550/591 of 5wkcA
- active site: Y29 (≠ H42), G31 (vs. gap), G32 (= G43), A33 (≠ N44), I34 (≠ V45), E55 (= E67), T78 (= T90), F117 (≠ L131), Q118 (= Q132), E119 (≠ Q133), K167 (≠ Q190), R222 (≠ A249), M258 (≠ V285), V285 (≠ T312), V401 (≠ A416), L426 (≠ F441), G427 (≠ S442), M429 (= M444), D454 (= D473), N481 (= N500), E483 (≠ G502), Q484 (≠ F503), M486 (≠ V505), V487 (≠ I506), W490 (≠ L509), L512 (≠ H539), G517 (= G544), L518 (≠ A545)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ A416), G402 (= G417), Q403 (≠ G418), H404 (≠ L419), G427 (≠ S442), M429 (= M444), G453 (= G472), D454 (= D473), A455 (≠ G474), S456 (= S475), M459 (≠ L478), N481 (= N500), E483 (≠ G502), Q484 (≠ F503), G485 (≠ A504), M486 (≠ V505), V487 (≠ I506)
- binding ethaneperoxoic acid: G32 (= G43), Q118 (= Q132)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G211 (= G239), A212 (≠ G240), G213 (= G241), N216 (≠ Q243), T238 (= T265), L239 (≠ I266), Q240 (≠ A267), L256 (≠ V283), M258 (≠ V285), G278 (= G305), A279 (≠ T306), R280 (= R307), R284 (≠ F311), V285 (≠ T312), E311 (≠ N329), V312 (≠ A330), N316 (≠ D334), D330 (= D346), A331 (= A347), M406 (≠ A421), G424 (≠ F439)
- binding magnesium ion: D454 (= D473), N481 (= N500), E483 (≠ G502)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G43), A33 (≠ N44), V107 (≠ T121), F117 (≠ L131), K167 (≠ Q190), M258 (≠ V285), R284 (≠ F311), M486 (≠ V505), W490 (≠ L509)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (vs. gap), E55 (= E67)
Sites not aligning to the query:
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 30:566/607 of 6u9dB
- active site: Y33 (≠ H42), G35 (vs. gap), G36 (= G43), A37 (≠ N44), I38 (≠ V45), E59 (= E67), T82 (= T90), F121 (≠ L131), Q122 (= Q132), E123 (≠ Q133), K171 (≠ Q190), M274 (≠ V285), V301 (≠ T312), V417 (≠ A416), G443 (≠ S442), M445 (= M444), D470 (= D473), N497 (= N500), E499 (≠ G502), Q500 (≠ F503), M502 (≠ V505), V503 (≠ I506), W506 (≠ L509)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G43), V111 (≠ T121), P112 (≠ F122), F121 (≠ L131), K171 (≠ Q190), D299 (= D310), R300 (≠ F311), M502 (≠ V505), W506 (≠ L509)
- binding flavin-adenine dinucleotide: R161 (vs. gap), A228 (≠ G240), G229 (= G241), N232 (≠ Q243), T254 (= T265), L255 (≠ I266), Q256 (≠ A267), L272 (≠ V283), M274 (≠ V285), G294 (= G305), R296 (= R307), D298 (≠ Q309), R300 (≠ F311), V301 (≠ T312), E327 (≠ N329), V328 (≠ A330), N332 (≠ D334), D346 (= D346), A347 (= A347), M422 (≠ A421), G440 (≠ F439), G441 (= G440)
- binding magnesium ion: D470 (= D473), N497 (= N500)
- binding thiamine diphosphate: E59 (= E67), P85 (= P95), V417 (≠ A416), G418 (= G417), Q419 (≠ G418), H420 (≠ L419), G443 (≠ S442), M445 (= M444), A471 (≠ G474), S472 (= S475), N497 (= N500), E499 (≠ G502), Q500 (≠ F503), G501 (≠ A504), M502 (≠ V505), V503 (≠ I506)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 110:646/687 of P07342
- R241 (vs. gap) binding
- 355:376 (vs. 286:307, 45% identical) binding
- 407:426 (vs. 329:346, 15% identical) binding
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 26:555/596 of 1t9cA
- active site: Y29 (≠ H42), G31 (vs. gap), G32 (= G43), A33 (≠ N44), I34 (≠ V45), E55 (= E67), T78 (= T90), F117 (≠ L131), Q118 (= Q132), E119 (≠ Q133), K167 (≠ Q190), R227 (≠ A249), M263 (≠ V285), V290 (≠ T312), V406 (≠ A416), L431 (≠ F441), G432 (≠ S442), M434 (= M444), D459 (= D473), N486 (= N500), E488 (≠ G502), Q489 (≠ F503), M491 (≠ V505), V492 (≠ I506), W495 (≠ L509), L517 (≠ H539), G522 (= G544), L523 (≠ A545)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G43), V107 (≠ T121), P108 (≠ F122), F117 (≠ L131), K167 (≠ Q190), D288 (= D310), R289 (≠ F311), W495 (≠ L509)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G216 (= G239), A217 (≠ G240), G218 (= G241), N221 (≠ Q243), T243 (= T265), L244 (≠ I266), Q245 (≠ A267), L261 (≠ V283), M263 (≠ V285), H264 (≠ T286), G283 (= G305), A284 (≠ T306), R285 (= R307), D287 (≠ Q309), R289 (≠ F311), V290 (≠ T312), E316 (≠ N329), V317 (≠ A330), N321 (≠ D334), G334 (= G345), D335 (= D346), A336 (= A347), M411 (≠ A421), G429 (≠ F439), G430 (= G440)
- binding magnesium ion: D459 (= D473), N486 (= N500), E488 (≠ G502)
Sites not aligning to the query:
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 27:556/597 of 1t9aA
- active site: Y30 (≠ H42), G32 (vs. gap), G33 (= G43), A34 (≠ N44), I35 (≠ V45), E56 (= E67), T79 (= T90), F118 (≠ L131), Q119 (= Q132), E120 (≠ Q133), K168 (≠ Q190), R228 (≠ A249), M264 (≠ V285), V291 (≠ T312), V407 (≠ A416), L432 (≠ F441), G433 (≠ S442), M435 (= M444), D460 (= D473), N487 (= N500), E489 (≠ G502), Q490 (≠ F503), M492 (≠ V505), V493 (≠ I506), W496 (≠ L509), L518 (≠ H539), G523 (= G544), L524 (≠ A545)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G43), V108 (≠ T121), P109 (≠ F122), F118 (≠ L131), K168 (≠ Q190), M264 (≠ V285), D289 (= D310), R290 (≠ F311), M492 (≠ V505), V493 (≠ I506), W496 (≠ L509)
- binding flavin-adenine dinucleotide: R158 (vs. gap), G217 (= G239), A218 (≠ G240), G219 (= G241), N222 (≠ Q243), T244 (= T265), L245 (≠ I266), Q246 (≠ A267), L262 (≠ V283), M264 (≠ V285), H265 (≠ T286), G284 (= G305), A285 (≠ T306), R286 (= R307), D288 (≠ Q309), R290 (≠ F311), V291 (≠ T312), E317 (≠ N329), V318 (≠ A330), N322 (≠ D334), G335 (= G345), D336 (= D346), A337 (= A347), Q411 (≠ P420), M412 (≠ A421), G430 (≠ F439), G431 (= G440)
- binding magnesium ion: D460 (= D473), N487 (= N500), E489 (≠ G502)
- binding propyl trihydrogen diphosphate: V407 (≠ A416), G408 (= G417), Q409 (≠ G418), H410 (≠ L419), M435 (= M444), G459 (= G472), D460 (= D473), A461 (≠ G474), S462 (= S475), N487 (= N500), E489 (≠ G502), Q490 (≠ F503), G491 (≠ A504), M492 (≠ V505)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (≠ S442), M435 (= M444), M465 (≠ L478)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 26:555/596 of 1t9dA
- active site: Y29 (≠ H42), G31 (vs. gap), G32 (= G43), A33 (≠ N44), I34 (≠ V45), E55 (= E67), T78 (= T90), F117 (≠ L131), Q118 (= Q132), E119 (≠ Q133), K167 (≠ Q190), R227 (≠ A249), M263 (≠ V285), V290 (≠ T312), V406 (≠ A416), L431 (≠ F441), G432 (≠ S442), M434 (= M444), D459 (= D473), N486 (= N500), E488 (≠ G502), Q489 (≠ F503), M491 (≠ V505), V492 (≠ I506), W495 (≠ L509), L517 (≠ H539), G522 (= G544), L523 (≠ A545)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G43), A33 (≠ N44), V107 (≠ T121), P108 (≠ F122), F117 (≠ L131), K167 (≠ Q190), M263 (≠ V285), D288 (= D310), R289 (≠ F311), W495 (≠ L509)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G216 (= G239), A217 (≠ G240), G218 (= G241), N221 (≠ Q243), T243 (= T265), L244 (≠ I266), Q245 (≠ A267), M260 (≠ P282), L261 (≠ V283), H264 (≠ T286), G283 (= G305), A284 (≠ T306), R285 (= R307), D287 (≠ Q309), R289 (≠ F311), V290 (≠ T312), E316 (≠ N329), V317 (≠ A330), N321 (≠ D334), G334 (= G345), D335 (= D346), A336 (= A347), Q410 (≠ P420), M411 (≠ A421), G429 (≠ F439), G430 (= G440)
- binding magnesium ion: D459 (= D473), N486 (= N500), E488 (≠ G502)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E67), P81 (= P95), Q118 (= Q132), G432 (≠ S442), M434 (= M444), M464 (≠ L478)
Sites not aligning to the query:
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
22% identity, 87% coverage: 39:577/621 of query aligns to 28:558/599 of 1n0hA
- active site: Y31 (≠ H42), G33 (vs. gap), G34 (= G43), A35 (≠ N44), I36 (≠ V45), E57 (= E67), T80 (= T90), F119 (≠ L131), Q120 (= Q132), E121 (≠ Q133), K169 (≠ Q190), R230 (≠ A249), M266 (≠ V285), V293 (≠ T312), V409 (≠ A416), L434 (≠ F441), G435 (≠ S442), M437 (= M444), D462 (= D473), N489 (= N500), E491 (≠ G502), Q492 (≠ F503), M494 (≠ V505), V495 (≠ I506), W498 (≠ L509), L520 (≠ H539), G525 (= G544), L526 (≠ A545)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ A416), G410 (= G417), Q411 (≠ G418), H412 (≠ L419), G435 (≠ S442), M437 (= M444), G461 (= G472), D462 (= D473), A463 (≠ G474), S464 (= S475), M467 (≠ L478), N489 (= N500), E491 (≠ G502), Q492 (≠ F503), G493 (≠ A504), V495 (≠ I506)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G43), A35 (≠ N44), V109 (≠ T121), P110 (≠ F122), F119 (≠ L131), K169 (≠ Q190), M266 (≠ V285), D291 (= D310), R292 (≠ F311), V495 (≠ I506), W498 (≠ L509)
- binding flavin-adenine dinucleotide: R159 (vs. gap), G219 (= G239), A220 (≠ G240), G221 (= G241), N224 (≠ Q243), T246 (= T265), L247 (≠ I266), Q248 (≠ A267), L264 (≠ V283), G265 (= G284), M266 (≠ V285), H267 (≠ T286), G286 (= G305), A287 (≠ T306), R288 (= R307), D290 (≠ Q309), R292 (≠ F311), V293 (≠ T312), E319 (≠ N329), V320 (≠ A330), N324 (≠ D334), G337 (= G345), D338 (= D346), A339 (= A347), M414 (≠ A421), G432 (≠ F439), G433 (= G440)
- binding magnesium ion: D462 (= D473), N489 (= N500), E491 (≠ G502)
- binding thiamine diphosphate: Y31 (≠ H42), E57 (= E67), P83 (= P95)
Sites not aligning to the query:
Query Sequence
>3607861 FitnessBrowser__Dino:3607861
MREDTIRLTTAQAIIRYLNAQFIETDGTRQRVCGGGFGIFGHGNVTCLGEALHDHRETLP
LYRGQNEQSMGFAAAAYAKYHLRRRFMFCTASAGPGTANLLTASALAHANRLPMLMLCGD
TFLTRLPDPVLQQLEHYGNPALGLNDAFHAVTRYWDRITHPAQVIQSLPAALATMLDPAD
CGPAFLALPQDVQGWAYDYPRAFFEEKTHRIRRITPDADEVAEAAALLRSAERPVIIAGG
GVQYSGAVAELTGFAEAHGIPVIETIAGRANLLADHPLNIGPVGVTGSDSANAIAEQADV
ILAVGTRLQDFTTGSWTAFAQEARFIALNAARHDAGKHRALPIVGDAKLGLVALEAALGD
YRCPEAWRNYAQTERKGWDAYVADNVRPGNRPNSYAQAIGVVNALCEPRDRVVAAAGGLP
AEVTANWRTLDIGTVDVEFGFSCMGYEIAGGWGARIAQTEVEPEADTIVFCGDGSYLLMN
SDIYSSVLTRKKMIVLVLDNGGFAVINKLQNNTGNESFNNLLADAPTIPEAFGVDFVAHA
AAMGAEATQVANADELAEAFKAAKASDKTTVIVMSVDAYDGWTTQGHTWWEVGTPHVTDN
PKVREKHLEIEAERAKQRRGI
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory