SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 5210659 FitnessBrowser__PV4:5210659 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

Q9NUT2 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial ATP-binding cassette 1; M-ABC1; Mitochondrial sulfonylurea-receptor; MITOSUR from Homo sapiens (Human) (see 4 papers)
38% identity, 87% coverage: 76:616/620 of query aligns to 187:712/735 of Q9NUT2

query
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Q9NUT2

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507:514 (vs. 412:419, 63% identical) binding
GK 512:513 (= GK 417:418) mutation to AR: Renders the protein unstable.
K513 (= K418) mutation to A: Abolish binding to ATP.
A690 (≠ S594) to G: in a breast cancer sample; somatic mutation

Sites not aligning to the query:

152 V → I: in dbSNP:rs4148844
165 I → T: in a breast cancer sample; somatic mutation

5ochE The crystal structure of human abcb8 in an outward-facing state
38% identity, 86% coverage: 82:616/620 of query aligns to 52:572/576 of 5ochE

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binding adenosine-5'-diphosphate: D104 (≠ A137), Y341 (= Y374), C343 (≠ A388), S369 (= S414), G370 (= G415), G371 (≠ A416), G372 (= G417), K373 (= K418), T374 (≠ S419), T375 (= T420)
binding magnesium ion: T374 (≠ S419), D496 (= D540), E497 (= E541)
binding cholesterol hemisuccinate: P163 (= P196), F238 (≠ V275), S242 (= S279), N243 (≠ I280), F246 (≠ I283), Q282 (≠ A315), M285 (≠ V318), L288 (≠ I321), S289 (= S322), V295 (≠ I328)

Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 2 papers)
36% identity, 95% coverage: 24:614/620 of query aligns to 112:698/715 of Q9JI39

query
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Q9JI39

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S

M

D

A

G

L

L

R

R

A

A

S

G

V

A

T

Q

V

A

V

S

G

V

G

G

L

V

V

G

M

M

M

M

A

F

I

F

T

V

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S

L

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S

L

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T

A

A

T

L

F

V

V

L

L

L

S

A

V

V

V

P

P

L

P

V

I

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G

V

P

L

I

A

F

V

F

I

F

Y

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G

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Y

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R

R

E

K

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L

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R

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K

A

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T

Q

Q

D

D

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S

V

L

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A

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T

A

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E

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L

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E

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I

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E

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A

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A

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I

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Y

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N

V

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Y

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P

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-

Q

-

A

-

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-

A

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D

-

S

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E

-

E

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M

-

E

-

A

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G
|
G

K
|
K

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F

V

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S

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L

L

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L

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R

F

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D

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A

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Q

E

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P

V

V

I

L

F

F

A

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T
x
C

S

S

V

V

L

A

E

E

N

N

V

I

R

A

Y

Y

G

G

R

A

P

D

D

N

A

L

S

S

-

S

-

V

-

T

L

A

E

Q

E

Q

V

V

Q

E

A

R

A

A

C

A

V

E

A

V

A

A

R

N

A

A

D

A

E

E

F

F

I

I

A

R

D

S

F

F

S

P

E

Q

G

G

Y

F

Q

D

T

T

Y

V

L

V

G

G

E

E

R

K

G

G

V

I

R

L

L

L

S

S

G

G

G
|
G

Q

Q

K

K

Q

Q

R

R

I

I

A

A

I

I

A

A

R

R

A

A

I

L

L

L

A

K

D

N

R

P

P

K

V

I

L

L

L

L

L

L

D

D

E
|
E

A

A

T

T

S

S

A

A

L

L

D

D

A

A

V

E

S

N

E

E

Q

H

K

L

V

V

K

Q

Q

E

A

A

L

L

D

D

V

R

L

L

M

M

Q

E

G

G

R

R

T

T

T

V

L

L

I

I

I

I

A

A

H

H

R

R

L

L

A

S

T

T

V

I

L

K

N

N

A

A

D

N

R

F

I

V

L

A

V

V

M

L

D

D

K

H

G

G

E

K

L

I

I
x
C

A

E

S

H

G

G

T

T

H

H

G

E

E

E

-

L

L

L

M

L

Q

K

S

P

N

N

S

G

L

L

Y

Y

R

R

E

K

F

L

A

M

S

N

L

K

Q

Q

G497 (= G417) mutation to A: Decreases ATP binding about 50%.
K498 (= K418) mutation to R: Decreases ATP binding about 50%.
C547 (≠ T467) modified: S-glutathionyl cysteine; mutation to A: Does not affect ABCB10 glutathionylation.
G602 (= G519) mutation to D: Affects ATP hydrolysis but not binding.; mutation to V: Affects ATP hydrolysis but not binding.
E624 (= E541) mutation to Q: Affects ATP hydrolysis but not binding.
C675 (≠ I592) mutation to A: Prevents ABCB10 glutathionylation.

Sites not aligning to the query:

1:82 modified: transit peptide, Mitochondrion

Q9NRK6 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2 from Homo sapiens (Human) (see 5 papers)
36% identity, 93% coverage: 38:614/620 of query aligns to 162:733/738 of Q9NRK6

query
sites
Q9NRK6

G

G

F

L

L

A

R

Y

P

P

Y

E

R

R

G

R

K

R

V

L

I

A

A

A

A

A

I

V

V

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F

L

L

F

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I

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G

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S

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A

I

W

S

L

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S

S

L

A

G

P

Q

F

G

F

V

L

R

G

L

K

M

I

V

I

D

D

E

V

G

I

F

Y

L

T

R

N

E

P

N

T

G

V

E

D

R

Y

L

S

N

D

E

N

I

L

I

T

L

R

L

L

V
x
C

I

L

G

G

I

L

T

S

A

A

L

V

-

F

-

L

-
x
C

S

G

S

A

S

A

A

A

I

N

F

A

C

I

R

R

F

V

Y

Y

L

L

M

M

T

Q

W

T

L

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G

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Q

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A

N

D

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L

Y

F

D

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H

S

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I

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L

Q

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V

G

A

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Y

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A

D

R

K

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R

R

T

T

G

G

E

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V

L

I

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R

R

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S

A

S

D

D

A

T

T

A

L

L

L

L

Q

G

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R

V

S

V

V

G

T

S

E

S

N

L

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S

M

D

A

G

L

L

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R

A

A

S

G

V

A

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Q

V

A

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V

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G

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I

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S

M

M

M

M

A

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I

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N

L

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A

A

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A

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V

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I

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x
R

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-

Q

-

A

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S

-

A

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D

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-

A

-

E

-

E

-

M

-

E

-

A

A

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|
K

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S

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T

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L

L

L

L

Q

L

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R

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x
D

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A

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S

G

G

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T

I

I

A

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L

L

D

D

G

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I

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D

D

I

I

A

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I

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F

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x
C

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A

E

E

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N

V

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Y

Y

G

G

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D

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A

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I

A

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F

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Y

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V

G

G

E

E

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G

G

V

V

R

L

L

L

S
|
S

G

G

G

G

Q
|
Q

K

K

Q

Q

R

R

I

I

A

A

I

I

A

A

R

R

A

A

I

L

L

L

A

K

D

N

R

P

P

K

V

I

L

L

L

L

L

L

D
|
D

E
|
E

A

A

T

T

S

S

A

A

L

L

D

D

A

A

V

E

S

N

E

E

Q

Y

K

L

V

V

K

Q

Q

E

A

A

L

L

D

D

V

R

L

L

M

M

Q

D

G

G

R

R

T

T

T

V

L

L

I

V

I

I

A

A

H

H

R

R

L

L

A

S

T

T

V

I

L

K

N

N

A

A

D

N

R

M

I

V

L

A

V

V

M

L

D

D

K

Q

G

G

E

K

L

I

I

T

A

E

S

Y

G

G

T

K

H

H

G

E

E

E

L

L

M

L

-

S

Q

K

S

P

N

N

S

G

L

I

Y

Y

R

R

E

K

F

L

A

M

S

N

L

K

Q

Q

C215 (≠ V91) mutation to S: Does not affect ATPase activity; when associated with L-224 and G-582. Activated by Zn (II) mesoporphyrin; when associated with L-224 and G-582.
C224 (vs. gap) mutation to L: Does not affect ATPase activity; when associated withS-215 and G-582. Activated by Zn (II) mesoporphyrin; when associated with S-215 and G-582.
R471 (≠ T344) to T: in a breast cancer sample; somatic mutation
K533 (= K418) mutation to E: Increases hemoglobin biosynthetic process.
D545 (≠ V430) to N: in dbSNP:rs35698797
C582 (≠ T467) mutation to G: Does not affect ATPase activity; when associated with S-215 and L-224. Activated by Zn (II) mesoporphyrin; when associated with S-215 and L-224.
S635 (= S517) mutation to R: Does not rescue hemoglobin and heme biosynthetic process.
Q638 (= Q520) mutation to H: Does not rescue hemoglobin and heme biosynthetic process.
D658 (= D540) mutation to A: Does not rescue hemoglobin and heme biosynthetic process.
E659 (= E541) mutation to A: Does not rescue hemoglobin and heme biosynthetic process.

Sites not aligning to the query:

150 A → S: in dbSNP:rs4148756

4ayxA Structure of the human mitochondrial abc transporter, abcb10 (rod form b) (see paper)
36% identity, 91% coverage: 38:601/620 of query aligns to 9:566/571 of 4ayxA

query
sites
4ayxA

G

G

F

L

L

A

R

Y

P

P

Y

E

R

R

G

R

K
x
R

V

L

I

A

A

A

A

A

I

V

V

G

F

F

L

L

F

T

I

M

G

S

S

S

L

V

A

I

W

S

L

M

S

S

L

A

G

P

Q

F

G

F

V

L

R

G

L

K

M

I

V

I

D

D

E

V

G

I

F

Y

L

T

R

N

E

P

N

T

G

V

E

D

R

Y

L

S

N

D

E

N

I

L

I

T

L

R

L

L

V

C

I

L

G

G

I

L

T

S

A

A

L

V

-

F

-

L

-

C

S

G

S

A

S

A

A

A

I

N

F

A

C

I

R

R

F

V

Y
|
Y

L

L

M

M

T

Q

W

T

L

S

G

G

E

Q

R
|
R

V

I

S

V

A

N

D

R

I

L

R

R

L

T

K

S

V

L

Y

F

D

S

H

S

L

I

L

L

K

R

L

Q

S

E

P

V

G

A

F

F

Y

F

A
x
D

R

K

L

T

R

R

T

T

G

G

E

E

V

L

I

I

S

N

R

R

F

L

T

S

A

S

D

D

A

T

T

A

L

L

L

L

Q

G

S

R

V

S

V

V

G

T

S

E

S

N

L

L

S

S

M

D

A

G

L

L

R

R

A

A

S

G

V

A

T

Q

V

A

V

S

G

V

G

G

L

I

V

S

M

M

M

M

A

F

I

F

T

V

S

S

L

P

K

N

L

L

T

A

A

T

L

F

V

V

L

L

L

S

A

V

V

V

P

P

L

P

V

V

L

S

G

I

P

I

I

A

F

V

F

I

F

Y

G

G

R

R

K

Y

V

L

R

R

E

K

L

L

S

T

R

K

K

V

S

T

Q

Q

D

D

R

S

V

L

G

A

D

Q

L

A

G

T

A

Q

Y

L

V

A

D

E

E

E

S

R

L

I

H

G

E

N

I

V

H

R

T

T

V

V

Q

R

A

A

Y

F

C

G

H

K

E

E

D

M

R

T

D

E

R

I

Q

E

L

K

F

Y

S

A

E

S

R

K

V

V

E

D

A

H

V

V

M

M

E

Q

A

L

A

A

R

R

G

K

R

E

I

A

K

F

Y

A

R

R

A

A

I

G

L

F

I

F

S

G

L

A

V

T

M

G

F

L

L

S

S

G

I

N

L

L

A

I

I

V

A

L

L

S

I

V

T

L

W

Y

V

K

G

G

A

G

K

L

D

L

V

M

M

G

S

S

E

A

A

H

I

M

T

T

P

V

G

G

E

E

L

L

S

S

A

S

F

F

M

L

F

M

Y

Y

A

A

V

F

M

W

V

V

A

G

G

I

A

S

V

I

A

G

T

G

I

L

S

S

E

S

V

F

I

Y

G

S

E

E

I

L

Q

M

R

K

A

G

A

L

G

G

A

A

T

G

E

G

R

R

L

L

I

W

E

E

L

L

V

L

E

E

T

R

P

E

I

P

D

K

I

L

P

P

L

F

A

N

P

E

K

G

P

V

V

I

S

L

L

N

P

E

A

K

K

S

V

F

R

Q

G

G

E

A

L

L

S

E

L

F

E

K

Q

N

V

V

R

H

F

F

S

A

Y
|
Y

P

P

V

-

Q

-

A

-

S

-

A

-

D

-

S

-

A

-

E

-

E

-

M

-

E

-

A
|
A

Q
x
R

A

P

G

E

V

V

E

P

V
x
I

I

F

R

Q

G

D

L

F

S

S

L

L

H

S

I

I

A

P

P

S

G

G

E

S

R

V

V

T

A

A

L

L

V

V

G

G

A

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

V

F

L

E

S

L

L

L

L

Q

L

R

R

F

L

Y

Y

V

D

L

P

D

A

S

S

G

G

V

T

I

I

A

S

L

L

D

D

G

G

I

H

D

D

I

I

A

R

S

Q

L

L

R

N

P

P

Q

V

D

W

L

L

R

R

Q

S

Q

K

Y

I

A

G

L

T

V

V

P

S

Q
|
Q

E

E

S

P

V

I

I

L

F

F

A

S

T

C

S

S

V

I

L

A

E

E

N

N

V

I

R

A

Y

Y

G

G

R

A

P

D

D

D

A

P

S

S

-

S

-

V

-

T

L

A

E

E

E

E

V

I

Q

Q

A

R

A

V

C

A

V

E

A

V

A

A

R

N

A

A

D

V

E

A

F

F

I

I

A

R

D

N

F

F

S

P

E

Q

G

G

Y

F

Q

N

T

T

Y

V

L

V

G

G

E

E

R

K

G

G

V

V

R

L

L

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

I

I

A

A

I

I

A

A

R

R

A

A

I

L

L

L

A

K

D

N

R

P

P

K

V

I

L

L

L

L

L

L

D
|
D

E

E

A

A

T

T

S

S

A

A

L

L

D

D

A

A

V

E

S

N

E

E

Q

Y

K

L

V

V

K

Q

Q

E

A

A

L

L

D

D

V

R

L

L

M

M

Q

D

G

G

R

R

T

T

T

V

L

L

I

V

I

I

A

A

H

H

R

R

L

L

A

S

T

T

V

I

L

K

N

N

A

A

D

N

R

M

I

V

L

A

V

V

M

L

D

D

K

Q

G

G

E

K

L

I

I

T

A

E

S

Y

G

G

T

K

H

H

G

E

E

E

L

L

M

L

binding phosphomethylphosphonic acid adenylate ester: D111 (≠ A137), Y348 (= Y374), A350 (= A388), R351 (≠ Q389), I356 (≠ V394), S376 (= S414), G377 (= G415), S378 (≠ A416), G379 (= G417), K380 (= K418), S381 (= S419), T382 (= T420), Q422 (= Q460)
binding glycine: R17 (≠ K46), Y81 (= Y107), R89 (= R115)
binding magnesium ion: S381 (= S419), Q422 (= Q460), D505 (= D540)

2onjA Structure of the multidrug abc transporter sav1866 from s. Aureus in complex with amp-pnp (see paper)
32% identity, 93% coverage: 39:616/620 of query aligns to 8:578/578 of 2onjA

query
sites
2onjA

F

F

L

V

R

K

P

P

Y

Y

R

K

G

Y

K

R

V

I

I

F

A

A

A

T

I

I

V

I

F

V

L

G

F

I

I

I

G

K

S

F

L

G

A

I

W

P

L

M

S

L

L

I

G

P

Q

L

G

L

V

I

R

K

L

Y

M

A

V

I

D

D

E

-

G

G

F

V

L

I

R

N

E

N

N

H

G

A

E

L

R

T

L

T

N

D

E

E

I

K

I

V

-

H

-

H

-

L

L

T

L

I

V

A

I

I

G

G

I

I

T

A

A

L

L

F

S

I

S

F

S

V

A

I

I

V

-

R

-

P

-

P

-

I

-

E

F

F

C

I

R

R

F

Q

Y

Y

L

L

M

A

T

Q

W

W

L

T

G

S

E

N

R

K

V

I

S

L

A

Y

D

D

I

I

R

R

L

K

K

K

V

L

Y

Y

D

N

H

H

L

L

L

Q

K

A

L

L

S

S

P

A

G

R

F

F

Y

Y

A

A

R

N

L

N

R

Q

T

V

G

G

E

Q

V

V

I

I

S

S

R

R

F

V

T

I

A

N

D

D

A

V

T

E

L

Q

L

T

Q

K

S

D

V

F

V

I

G

L

S

T

S

G

L

L

S

M

M

N

A

I

L

W

R

L

A

D

S

C

V

I

T

T

V

I

V

I

G

I

G

A

L

L

V

S

M

I

M

M

A

F

I

F

T

L

S

D

L

V

K

K

L

L

T

T

A

L

L

A

V

A

L

L

L

F

A

I

V

F

P

P

L

F

V

Y

L

I

G

L

P

T

I

V

F

Y

F

V

F

F

G

F

R

G

K

R

V

L

R

R

E

K

L

L

S

T

R

R

K

E

S

R

Q

S

D

Q

R

A

V

L

G

A

D

E

L

V

G

Q

A

G

Y

F

V

L

D

H

E

E

S

R

L

V

H

Q

E

G

I

I

H

S

T

V

V

V

Q

K

A

S

Y

F

C

A

H

I

E

E

D

D

R

N

D

E

R

A

Q

K

L

N

F

F

S

D

E

K

R

K

V

N

E

T

A

N

V

F

M

L

E

T

A

R

A

A

R

L

G

K

R

H

I

T

K

R

Y

W

R

N

A

A

I

Y

L

S

I

F

S

A

L

A

V

I

M

N

F

T

L

V

S

T

I

D

L

I

A

G

I

P

A

I

L

I

I

V

T

I

W

G

V

V

G

G

A

A

K

Y

D

L

V

A

M

I

S

S

E

G

A

S

I

I

T

T

P

V

G

G

E

T

L

L

S

A

A

A

F

F

M

V

F

G

Y

Y

A

L

V

E

M

L

V

L

A

F

G

G

A

P

V

L

A

R

T

R

I

L

S

V

E

A

V

S

I

F

G

T

E

T

I

L

Q

T

R

Q

A

S

A

F

G

A

A

S

T

M

E

D

R

R

L

V

I

F

E

Q

L

L

V

I

E

D

T

E

P

D

I

Y

D

D

I

I

P

K

-

N

-

G

L

V

A

G

P

A

K

Q

P

P

V

I

S

E

L

I

P

K

A

-

K

-

V

-

R

Q

G

G

E

R

L

I

S

D

L

I

E

D

Q

H

V

V

R

S

F

F

S

Q

Y
|
Y

P

-

V

-

Q

-

A

-

S

-

A

-

D

-

S

-

A

-

E

N

E

D

M

N

E

E

A

A

Q

-

A

-

G

-

V

-

E

P

V
x
I

I

L

R

K

G

D

L

I

S

N

L

L

H

S

I

I

A

E

P

K

G

G

E

E

R

T

V

V

A

A

L

F

V

V

G

G

A

M

S
|
S

G
|
G

A
x
G

G
|
G

K
|
K

S
|
S

T
|
T

L

L

F

I

E

N

L

L

L

I

Q

P

R

R

F

F

Y

Y

V

D

L

V

D

T

S

S

G

G

V

Q

I

I

A

L

L

I

D

D

G

G

I

H

D

N

I

I

A

K

S

D

L

F

R

L

P

T

Q

G

D

S

L

L

R

R

Q

N

Q

Q

Y

I

A

G

L

L

V

V

P

Q

Q
|
Q

E

D

S

N

V

I

I

L

F

F

A

S

T

D

S

T

V

V

L

K

E

E

N

N

V

I

R

L

Y

L

G

G

R

R

P

P

D

T

A

A

S

T

L

D

E

E

E

E

V

V

Q

V

A

E

A

A

C

A

V

K

A

M

A

A

R

N

A

A

D

H

E

D

F

F

I

I

A

M

D

N

F

L

S

P

E

Q

G

G

Y

Y

Q

D

T

T

Y

E

L

V

G

G

E

E

R

R

G

G

V
|
V

R
x
K

L

L

S
|
S

G
|
G

G
|
G

Q

Q

K

K

Q

Q

R

R

I

L

A

S

I

I

A

A

R

R

A

I

I

F

L

L

A

N

D

N

R

P

P

P

V

I

L

L

L

I

L

L

D

D

E
|
E

A

A

T

T

S

S

A
|
A

L

L

D

D

A

L

V

E

S

S

E

E

Q

S

K

I

V

I

K

Q

Q

E

A

A

L

L

D

D

V

V

L

L

M

S

Q

K

G

D

R

R

T

T

T

T

L

L

I

I

I

V

A

A

H
|
H

R

R

L

L

A

S

T

T

V

I

L

T

N

H

A

A

D

D

R

K

I

I

L

V

V

V

M

I

D

E

K

N

G

G

E

H

L

I

I

V

A

E

S

T

G

G

T

T

H

H

G

R

E

E

L

L

M

I

Q

A

S

K

N

Q

S

G

L

A

Y

Y

R

E

E

H

F

L

A

Y

S

S

L

I

Q

Q

L

N

L

L

binding phosphoaminophosphonic acid-adenylate ester: Y349 (= Y374), I356 (≠ V394), S376 (= S414), G377 (= G415), G378 (≠ A416), G379 (= G417), K380 (= K418), S381 (= S419), T382 (= T420), Q422 (= Q460), V476 (= V514), K477 (≠ R515), S479 (= S517), G480 (= G518), G481 (= G519), E503 (= E541), A507 (= A545), H534 (= H572)

2hydA Multidrug abc transporter sav1866 (see paper)
32% identity, 93% coverage: 39:616/620 of query aligns to 8:578/578 of 2hydA

query
sites
2hydA

F

F

L

V

R

K

P

P

Y

Y

R

K

G

Y

K

R

V

I

I

F

A

A

A

T

I

I

V

I

F

V

L

G

F

I

I

I

G

K

S

F

L

G

A

I

W

P

L

M

S

L

L

I

G

P

Q

L

G

L

V

I

R

K

L

Y

M

A

V

I

D

D

E

-

G

G

F

V

L

I

R

N

E

N

N

H

G

A

E

L

R

T

L

T

N

D

E

E

I

K

I

V

-

H

-

H

-

L

L

T

L

I

V

A

I

I

G

G

I

I

T

A

A

L

L

F

S

I

S

F

S

V

A

I

I

V

-

R

-

P

-

P

-

I

-

E

F

F

C

I

R

R

F

Q

Y

Y

L

L

M

A

T

Q

W

W

L

T

G

S

E

N

R

K

V

I

S

L

A

Y

D

D

I

I

R

R

L

K

K

K

V

L

Y

Y

D

N

H

H

L

L

L

Q

K

A

L

L

S

S

P

A

G

R

F

F

Y

Y

A

A

R

N

L

N

R

Q

T

V

G

G

E

Q

V

V

I

I

S

S

R

R

F

V

T

I

A

N

D

D

A

V

T

E

L

Q

L

T

Q

K

S

D

V

F

V

I

G

L

S

T

S

G

L

L

S

M

M

N

A

I

L

W

R

L

A

D

S

C

V

I

T

T

V

I

V

I

G

I

G

A

L

L

V

S

M

I

M

M

A

F

I

F

T

L

S

D

L

V

K

K

L

L

T

T

A

L

L

A

V

A

L

L

L

F

A

I

V

F

P

P

L

F

V

Y

L

I

G

L

P

T

I

V

F

Y

F

V

F

F

G

F

R

G

K

R

V

L

R

R

E

K

L

L

S

T

R

R

K

E

S

R

Q

S

D

Q

R

A

V

L

G

A

D

E

L

V

G

Q

A

G

Y

F

V

L

D

H

E

E

S

R

L

V

H

Q

E

G

I

I

H

S

T

V

V

V

Q

K

A

S

Y

F

C

A

H

I

E

E

D

D

R

N

D

E

R

A

Q

K

L

N

F

F

S

D

E

K

R

K

V

N

E

T

A

N

V

F

M

L

E

T

A

R

A

A

R

L

G

K

R

H

I

T

K

R

Y

W

R

N

A

A

I

Y

L

S

I

F

S

A

L

A

V

I

M

N

F

T

L

V

S

T

I

D

L

I

A

G

I

P

A

I

L

I

I

V

T

I

W

G

V

V

G

G

A

A

K

Y

D

L

V

A

M

I

S

S

E

G

A

S

I

I

T

T

P

V

G

G

E

T

L

L

S

A

A

A

F

F

M

V

F

G

Y

Y

A

L

V

E

M

L

V

L

A

F

G

G

A

P

V

L

A

R

T

R

I

L

S

V

E

A

V

S

I

F

G

T

E

T

I

L

Q

T

R

Q

A

S

A

F

G

A

A

S

T

M

E

D

R

R

L

V

I

F

E

Q

L

L

V

I

E

D

T

E

P

D

I

Y

D

D

I

I

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binding adenosine-5'-diphosphate: Y349 (= Y374), I356 (≠ V394), S376 (= S414), G377 (= G415), G378 (≠ A416), G379 (= G417), K380 (= K418), S381 (= S419), T382 (= T420), Y391 (= Y429), L463 (≠ F501), V476 (= V514), K477 (≠ R515), S479 (= S517), Q482 (= Q520)

7y48B Cryo-em structure of biliverdin-bound mitochondrial abc transporter abcb10 from biortus
35% identity, 91% coverage: 38:601/620 of query aligns to 8:562/567 of 7y48B

query
sites
7y48B

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