Comparing AZOBR_RS21180 FitnessBrowser__azobra:AZOBR_RS21180 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1h16A Pyruvate formate-lyase (e.Coli) in complex with pyruvate and coa (see paper)
65% identity, 97% coverage: 21:756/760 of query aligns to 11:755/759 of 1h16A
P09373 Formate acetyltransferase 1; Pyruvate formate-lyase 1; EC 2.3.1.54 from Escherichia coli (strain K12) (see 4 papers)
65% identity, 97% coverage: 21:756/760 of query aligns to 12:756/760 of P09373
Sites not aligning to the query:
1cm5A Crystal structure of c418a,c419a mutant of pfl from e.Coli (see paper)
65% identity, 97% coverage: 21:756/760 of query aligns to 11:755/759 of 1cm5A
1r9dA Glycerol bound form of the b12-independent glycerol dehydratase from clostridium butyricum (see paper)
27% identity, 86% coverage: 102:757/760 of query aligns to 66:784/786 of 1r9dA
6vueA Wild-type choline tma lyase in complex with 1-methyl-1,2,3,6- tetrahydropyridin-3-ol (see paper)
25% identity, 66% coverage: 256:758/760 of query aligns to 268:802/803 of 6vueA
Sites not aligning to the query:
2f3oA Crystal structure of a glycyl radical enzyme from archaeoglobus fulgidus (see paper)
26% identity, 65% coverage: 259:754/760 of query aligns to 248:768/773 of 2f3oA
Sites not aligning to the query:
5fawB T502a mutant of choline tma-lyase (see paper)
25% identity, 66% coverage: 256:758/760 of query aligns to 271:805/806 of 5fawB
Sites not aligning to the query:
Q30W70 Choline trimethylamine-lyase; Choline TMA-lyase; Choline utilization protein C; Glycyl radical enzyme CutC; GRE CutC; EC 4.3.99.4 from Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) (Desulfovibrio alaskensis) (see 2 papers)
25% identity, 66% coverage: 256:758/760 of query aligns to 311:845/846 of Q30W70
Sites not aligning to the query:
6nd3A Wild-type choline tma lyase in complex with betaine aldehyde (see paper)
25% identity, 66% coverage: 256:758/760 of query aligns to 260:794/795 of 6nd3A
Sites not aligning to the query:
7vuaA Anaerobic hydroxyproline degradation involving c-n cleavage by a glycyl radical enzyme (see paper)
24% identity, 68% coverage: 238:757/760 of query aligns to 232:782/785 of 7vuaA
6vxeA Crystal structure of hydroxyproline dehydratase (hypd) from clostridioides difficile with substrate trans-4-hydroxy-l-proline bound (see paper)
25% identity, 71% coverage: 218:755/760 of query aligns to 217:785/789 of 6vxeA
Sites not aligning to the query:
A0A031WDE4 Trans-4-hydroxy-L-proline dehydratase; Glycyl radical enzyme; Hyp dehydratase; EC 4.2.1.172 from Clostridioides difficile (Peptoclostridium difficile) (see paper)
25% identity, 71% coverage: 218:755/760 of query aligns to 217:785/789 of A0A031WDE4
5ymrB The crystal structure of iseg (see paper)
26% identity, 68% coverage: 238:757/760 of query aligns to 238:795/798 of 5ymrB
Sites not aligning to the query:
Q727N1 Isethionate sulfite-lyase; C-S lyase IseG; Glycyl radical enzyme IseG; GRE IseG; EC 4.4.1.38 from Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) (see paper)
26% identity, 68% coverage: 238:757/760 of query aligns to 268:825/828 of Q727N1
Sites not aligning to the query:
5a0uH Structure of cutc choline lyase choline bound form from klebsiella pneumoniae. (see paper)
25% identity, 69% coverage: 228:755/760 of query aligns to 234:790/795 of 5a0uH
Sites not aligning to the query:
6lonA Crystal structure of hpsg (see paper)
25% identity, 69% coverage: 238:758/760 of query aligns to 244:802/804 of 6lonA
Sites not aligning to the query:
E5Y7I4 (2S)-3-sulfopropanediol sulfolyase; (S)-DHPS sulfolyase; EC 4.4.1.41 from Bilophila wadsworthia (strain 3_1_6) (see paper)
25% identity, 69% coverage: 238:758/760 of query aligns to 264:822/824 of E5Y7I4
Sites not aligning to the query:
7kq3A Structure of isethionate sulfite-lyase from bilophila wadsworthia with substrate isethionate bound (see paper)
25% identity, 68% coverage: 239:757/760 of query aligns to 266:822/825 of 7kq3A
Sites not aligning to the query:
7e7lA The crystal structure of arylacetate decarboxylase from olsenella scatoligenes.
22% identity, 66% coverage: 254:755/760 of query aligns to 231:767/770 of 7e7lA
Sites not aligning to the query:
Q38HX4 4-hydroxyphenylacetate decarboxylase glycyl radical subunit; HPA decarboxylase glycyl radical subunit; 4-hydroxyphenylacetate decarboxylase catalytic beta subunit; 4-hydroxyphenylacetate decarboxylase large subunit; p-hydroxyphenylacetate decarboxylase large subunit; EC 4.1.1.83 from Clostridium scatologenes (see paper)
22% identity, 66% coverage: 253:755/760 of query aligns to 319:893/897 of Q38HX4
>AZOBR_RS21180 FitnessBrowser__azobra:AZOBR_RS21180
MDSLMFEPKIPVAEAETPNPWRGFAPGSWRTTVDLRDFIVKNVRPYGGDGSFLSPASDRT
LSLWNKVRDLLKEERAAKGGVLDADTELVSSIVSHAPGYIDRELEVIVGLQTDKPLKRSI
MPFGGWRMVKTGLEAYGFKPSPKLDDVFPALRKTHNDGVFDVYTEEMLRCRKSGVITGLP
DAYGRGRIIGDYRRLALYGATFLIEDKKAQYKSLEVDRIDENTLRLREEITEQIRALRDL
VTMAASYGFDVSRPATNAFEAVQWTYLAYLAAVKEANGAAMSLGRVSSFLDVYIERDLRE
GRLDEAGAQELIDQFVIKLRMVRFLRTPEYDQLFSGDPTWVTECIGGMALDGRTLVTKGS
FRMLHTLQNLGPAPEPNLTVLWSESLPEGFKKFCAETSIKTCSVQYENDDLMRPFWGDDY
GIACCVSAMRIGKQMQFFGARANLAKTLLYAINGGRDEVSGEQVGPAFAPITGDVLDHDT
VVARLLPMMEWLARAYMNTLNAIHFMHDKYMYERLEMALHDRDVLRTMACGIAGLSVVAD
SLSAIKHATVKVVRDERGLATDFVIEGDYPAFGNNDDRVDGIAVWLVETFMGLLRKQKAY
RDAVPTQSVLTITSNVVYGKKTGNTPDGRKAGQPFAPGANPMHGRDRKGAIASMASVAKL
PYAHAQDGISYTFTIVPGALGPTEGERVANLVGMLDGYFGQGGHHINVNVFDRETLLHAM
DHPELYPQLTIRVSGYAVNFIKLTREQQMDVISRTFHGAH
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory