Comparing Ac3H11_4087 FitnessBrowser__acidovorax_3H11:Ac3H11_4087 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 12 hits to proteins with known functional sites (download)
2cdqA Crystal structure of arabidopsis thaliana aspartate kinase complexed with lysine and s-adenosylmethionine (see paper)
27% identity, 73% coverage: 117:462/473 of query aligns to 94:458/470 of 2cdqA
Sites not aligning to the query:
3tviE Crystal structure of clostridium acetobutylicum aspartate kinase (caak): an important allosteric enzyme for industrial amino acids production (see paper)
25% identity, 80% coverage: 84:462/473 of query aligns to 51:436/439 of 3tviE
2hmfA Structure of a threonine sensitive aspartokinase from methanococcus jannaschii complexed with mg-adp and aspartate (see paper)
28% identity, 45% coverage: 247:459/473 of query aligns to 236:458/464 of 2hmfA
Sites not aligning to the query:
3c1nA Crystal structure of allosteric inhibition threonine-sensitive aspartokinase from methanococcus jannaschii with l-threonine (see paper)
25% identity, 95% coverage: 10:459/473 of query aligns to 2:453/458 of 3c1nA
3c1mC Cyrstal structure of threonine-sensitive aspartokinase from methanococcus jannaschii with mgamp-pnp and l-aspartate (see paper)
28% identity, 45% coverage: 247:459/473 of query aligns to 236:462/468 of 3c1mC
Sites not aligning to the query:
3tviA Crystal structure of clostridium acetobutylicum aspartate kinase (caak): an important allosteric enzyme for industrial amino acids production (see paper)
24% identity, 80% coverage: 84:462/473 of query aligns to 49:428/429 of 3tviA
Sites not aligning to the query:
O60163 Probable aspartokinase; Aspartate kinase; EC 2.7.2.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
24% identity, 77% coverage: 95:460/473 of query aligns to 102:489/519 of O60163
O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 95% coverage: 10:459/473 of query aligns to 90:548/916 of O81852
3l76A Crystal structure of aspartate kinase from synechocystis (see paper)
25% identity, 60% coverage: 184:469/473 of query aligns to 111:411/585 of 3l76A
Sites not aligning to the query:
P08660 Lysine-sensitive aspartokinase 3; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III; EC 2.7.2.4 from Escherichia coli (strain K12) (see paper)
22% identity, 96% coverage: 7:462/473 of query aligns to 2:447/449 of P08660
2j0xA Crystal structure of e. Coli aspartokinase iii in complex with lysine and aspartate (t-state) (see paper)
22% identity, 96% coverage: 8:462/473 of query aligns to 1:445/447 of 2j0xA
2j0wA Crystal structure of e. Coli aspartokinase iii in complex with aspartate and adp (r-state) (see paper)
22% identity, 96% coverage: 8:462/473 of query aligns to 1:445/447 of 2j0wA
>Ac3H11_4087 FitnessBrowser__acidovorax_3H11:Ac3H11_4087
MQDVQNSKISVEKIGGTSMTAFGDVLRHIMLHDPKRIYGRIYVVSAYSGVTNQLLEHKKT
GERGIYALFAEGKGYQDALVNLATSLKKLNAGYADLGLPLDVADAFIDQRIGQAREYLSA
MQHVLASGYLSRHDVLLAAREVLASIGESHSAFNSVEILKANGVKAVLMDLAGFDDNEAW
TIDERIAHSFKGLDLSDKVVVATGYTKGTEGIMREFDRGYSEVTFSKIAVEVRPAEAVIH
KEFHLSSADPNLVGLENAIVVGATNYDVADQLADVGMEAIHPKAAKPMELAGIPIRLKNT
FEPDHPGTLITKDFVGERARVEIVTGTDKVTLIEIHDPSMVGTVGFDAGLMNVFCKHEVS
YILKATNANSIAHLMWDSQVTPELVAELQKDYQVVTIKPSAIVCTIGSNIGIPGVLAKAA
QALADAQVNVNCVSQTLRQVNMQFVIEREDYKTAIKALNMALCVNSGAPVPRA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory