Comparing BWI76_RS13125 FitnessBrowser__Koxy:BWI76_RS13125 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6aa8E Crystal structure of (s)-3-hydroxybutyryl-coenzymea dehydrogenase from clostridium acetobutylicum complexed with NAD+ (see paper)
45% identity, 59% coverage: 8:285/473 of query aligns to 3:279/281 of 6aa8E
4kuhA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with acetoacetyl-coa from clostridium butyricum
44% identity, 59% coverage: 5:285/473 of query aligns to 1:280/280 of 4kuhA
4kugA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with NAD from clostridium butyricum
44% identity, 59% coverage: 5:285/473 of query aligns to 1:280/282 of 4kugA
P00348 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; L-3-hydroxyacyl CoA dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Sus scrofa (Pig) (see paper)
39% identity, 59% coverage: 8:285/473 of query aligns to 30:313/314 of P00348
Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Homo sapiens (Human) (see 7 papers)
39% identity, 59% coverage: 8:285/473 of query aligns to 30:313/314 of Q16836
1f17A L-3-hydroxyacyl-coa dehydrogenase complexed with nadh (see paper)
40% identity, 59% coverage: 8:288/473 of query aligns to 7:293/293 of 1f17A
1f12A L-3-hydroxyacyl-coa dehydrogenase complexed with 3-hydroxybutyryl-coa (see paper)
40% identity, 59% coverage: 8:288/473 of query aligns to 7:293/293 of 1f12A
1f0yA L-3-hydroxyacyl-coa dehydrogenase complexed with acetoacetyl-coa and NAD+ (see paper)
40% identity, 59% coverage: 8:285/473 of query aligns to 7:290/291 of 1f0yA
4pzeA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with acetoacetyl-coa (see paper)
38% identity, 60% coverage: 4:285/473 of query aligns to 1:281/283 of 4pzeA
4pzdA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with NAD+ (see paper)
38% identity, 60% coverage: 4:285/473 of query aligns to 1:281/283 of 4pzdA
P9WNP7 3-hydroxybutyryl-CoA dehydrogenase; Beta-hydroxybutyryl-CoA dehydrogenase; BHBD; EC 1.1.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
40% identity, 60% coverage: 1:285/473 of query aligns to 1:286/286 of P9WNP7
6iunB Crystal structure of enoyl-coa hydratase (ech) from ralstonia eutropha h16 in complex with NAD
36% identity, 60% coverage: 2:287/473 of query aligns to 288:568/692 of 6iunB
Sites not aligning to the query:
8oqvA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-109
33% identity, 59% coverage: 8:285/473 of query aligns to 335:614/726 of 8oqvA
Sites not aligning to the query:
8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80
33% identity, 59% coverage: 8:285/473 of query aligns to 337:616/728 of 8oqrA
Sites not aligning to the query:
8oqqA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-79
33% identity, 59% coverage: 8:285/473 of query aligns to 331:610/723 of 8oqqA
Sites not aligning to the query:
8oqpA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-76
33% identity, 59% coverage: 8:285/473 of query aligns to 331:610/723 of 8oqpA
Sites not aligning to the query:
7o4uA Structure of the alpha subunit of mycobacterium tuberculosis beta- oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide (see paper)
33% identity, 59% coverage: 8:285/473 of query aligns to 319:598/711 of 7o4uA
8pf8A Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
33% identity, 59% coverage: 8:285/473 of query aligns to 337:616/729 of 8pf8A
Sites not aligning to the query:
8oquA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-92
33% identity, 59% coverage: 8:285/473 of query aligns to 338:617/730 of 8oquA
Sites not aligning to the query:
8oqtA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-91
33% identity, 59% coverage: 8:285/473 of query aligns to 337:616/729 of 8oqtA
Sites not aligning to the query:
>BWI76_RS13125 FitnessBrowser__Koxy:BWI76_RS13125
MSKTLPTVAVIGSGTMGAGIAEVAAAAGHPVLIFDIAPEAVVRAIDGIRQRLASRVSRGK
LATEQADALLARLVPAAELSNLADAQLIIEAASERLEVKKALFEQLAAICSPSTLLVSNT
SSISITAIAAGIKHPERVAGLHFFNPAPVMKLVEVVSGLATSTEVVEQLCQWVSDWGKQP
VRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQD
VNFAVTCSVFNACWQDRRYQPSLLQQELALAGRLGKKSGQGVYRWPAEAQPERALAAVSA
ERAAKRIKRDVVTELDEILLLETTGETALALSLQHGRPVVVYDHCAGDTVVLASAETTSQ
AATDKATFYFQQQGKKVLQIADYPGLLVWRTVAMLVNEALDALQKGVASAEDIDTAMRLG
VNYPRGPLAWGESLGWGRVLRLLENLQRHYGEERYRPCSLLRQKALMEKHHEQ
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory