Comparing CA265_RS03135 FitnessBrowser__Pedo557:CA265_RS03135 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
Q93099 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Homo sapiens (Human) (see 13 papers)
24% identity, 74% coverage: 97:384/388 of query aligns to 128:428/445 of Q93099
Sites not aligning to the query:
Q9Y041 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Caenorhabditis elegans (see paper)
24% identity, 75% coverage: 94:384/388 of query aligns to 128:427/437 of Q9Y041
1ey2A Human homogentisate dioxygenase with fe(ii) (see paper)
23% identity, 64% coverage: 97:346/388 of query aligns to 127:372/419 of 1ey2A
4aq6D Substrate bound homogentisate 1,2-dioxygenase (see paper)
23% identity, 71% coverage: 109:385/388 of query aligns to 132:417/427 of 4aq6D
3zdsA Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen. (see paper)
23% identity, 71% coverage: 109:385/388 of query aligns to 130:415/425 of 3zdsA
3zdsF Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen. (see paper)
23% identity, 71% coverage: 109:385/388 of query aligns to 131:416/426 of 3zdsF
3zdsC Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen. (see paper)
23% identity, 71% coverage: 109:385/388 of query aligns to 131:416/426 of 3zdsC
Q88E47 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
23% identity, 71% coverage: 109:385/388 of query aligns to 138:423/433 of Q88E47
>CA265_RS03135 FitnessBrowser__Pedo557:CA265_RS03135
MPIYHKLGQIPAKRHTVFRKPDGNLYAEELVSTEGFSSLYSLVYHCHPPTIVKHLGEPYS
VEPKIAREKHLKHTSLIGFNITPEDDFLKSRKAVLVNNDLHIVLAAPRKSMTDYFYKNSQ
ADEMIFVHEGSGKLKTGFGEIKFAYGDYLIIPRGTIYQLEFDTEQNRLFIVESFSPLRPP
KRYLNQFGQLMEHAPYCERDLRLPENLQTHDEYGDFKVLIKKQGLIYPYTYGTHPFDYVG
WDGYHYPYAFSIHDFEPITGRLHQPPPVHQTFEGHNFVVCSFVPRKYDYHPDSIPAPYNH
SNVDSDEVLYYVDGDFMSRKSVFKGQITLHPGGIPHGPHPGTVEKSIGKEKTDELAVMID
PFKPLMLTQDALDIEDENYHKSWQVNIE
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory