SitesBLAST
Comparing CA265_RS09565 FitnessBrowser__Pedo557:CA265_RS09565 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9R7D7 Galactokinase; Galactose kinase; EC 2.7.1.6 from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) (see paper)
47% identity, 97% coverage: 5:379/388 of query aligns to 14:392/399 of Q9R7D7
1pieA Crystal structure of lactococcus lactis galactokinase complexed with galactose (see paper)
47% identity, 97% coverage: 5:379/388 of query aligns to 6:384/388 of 1pieA
- binding alpha-D-galactopyranose: E34 (= E32), H35 (= H33), D37 (= D35), Y38 (= Y36), S171 (= S166), D175 (= D170), Y225 (= Y220), A340 (= A335)
- binding phosphate ion: R28 (= R26), G127 (= G122), S129 (= S124), D175 (= D170)
P0A6T3 Galactokinase; Galactose kinase; EC 2.7.1.6 from Escherichia coli (strain K12) (see 2 papers)
35% identity, 97% coverage: 3:379/388 of query aligns to 1:378/382 of P0A6T3
- M1 (≠ I3) modified: Initiator methionine, Removed
- Y371 (= Y372) mutation to H: Displays relaxed substrate specificity since it gains kinase activity toward sugars as diverse as D-galacturonic acid, D-talose, L-altrose, and L-glucose. Also shows enhanced turnover of the small pool of sugars converted by the wild-type enzyme.
6q8zA Structure of human galactokinase 1 bound with n-(cyclobutylmethyl)-1, 5-dimethyl-1h-pyrazole-4-carboxamide
35% identity, 96% coverage: 6:379/388 of query aligns to 17:386/392 of 6q8zA
- binding beta-D-galactopyranose: E43 (= E32), H44 (= H33), D46 (= D35), Y47 (= Y36), G183 (= G167), M185 (= M169), D186 (= D170), Y236 (= Y220), G345 (= G334), G346 (≠ A335)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one: R105 (≠ L87), Y109 (= Y91), V129 (≠ F113), L135 (≠ I119), G136 (= G120), S141 (= S125), S142 (= S126)
- binding ~{N}-(cyclobutylmethyl)-1,5-dimethyl-pyrazole-4-carboxamide: A31 (≠ I20), V32 (≠ Y21), S33 (≠ F22)
Sites not aligning to the query:
6q3wC Structure of human galactokinase 1 bound with ethyl 1-(2-pyrazinyl)-4- piperidinecarboxylate
34% identity, 96% coverage: 6:379/388 of query aligns to 16:384/390 of 6q3wC
- binding beta-D-galactopyranose: E42 (= E32), H43 (= H33), D45 (= D35), Y46 (= Y36), G182 (= G167), M184 (= M169), D185 (= D170), Y235 (= Y220), G344 (≠ A335)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one: D82 (vs. gap), R104 (≠ L87), W105 (= W88), Y108 (= Y91), V128 (≠ F113), S130 (≠ G115), L134 (≠ I119), S140 (= S125), S141 (= S126), R227 (≠ P212)
- binding ethyl 1-pyrazin-2-ylpiperidine-4-carboxylate: R104 (≠ L87), N107 (= N90), Y108 (= Y91), A177 (≠ I162), G178 (= G163)
6qjeA Structure of human galactokinase 1 bound with 4-{[2-(methylsulfonyl)- 1h-imidazol-1-yl]methyl}-1,3-thiazole
34% identity, 96% coverage: 6:379/388 of query aligns to 15:384/390 of 6qjeA
- binding beta-D-galactopyranose: E41 (= E32), H42 (= H33), D44 (= D35), Y45 (= Y36), G181 (= G167), M183 (= M169), D184 (= D170), Y234 (= Y220), G344 (≠ A335)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one: S77 (vs. gap), Y107 (= Y91), V127 (≠ F113), S129 (≠ G115), L133 (≠ I119), S139 (= S125), S140 (= S126), R226 (≠ P212)
- binding 4-[(2-methylsulfonylimidazol-1-yl)methyl]-1,3-thiazole: R103 (≠ L87), A176 (≠ I162), G177 (= G163)
7s4cA Crystal structure of inhibitor-bound galactokinase (see paper)
34% identity, 96% coverage: 6:379/388 of query aligns to 16:385/391 of 7s4cA
- binding alpha-D-galactopyranose: E42 (= E32), H43 (= H33), D45 (= D35), Y46 (= Y36), G182 (= G167), D185 (= D170), Y235 (= Y220), G345 (≠ A335)
- binding phosphate ion: G135 (= G120), G137 (= G122), S139 (= S124), S140 (= S125), S141 (= S126), Q171 (≠ R156), H174 (≠ N159), H362 (≠ D352), H366 (≠ N356), E369 (≠ D359)
- binding 2-({(4R)-4-(2-chlorophenyl)-2-[(6-fluoro-1,3-benzoxazol-2-yl)amino]-6-methyl-1,4-dihydropyrimidine-5-carbonyl}amino)pyridine-4-carboxylic acid: M54 (≠ C44), D82 (vs. gap), R104 (≠ L87), W105 (= W88), Y108 (= Y91), L134 (≠ I119), S140 (= S125), L144 (≠ I129), K194 (= K179), L212 (≠ V197), D214 (≠ L199), L217 (≠ Y202), A218 (≠ V203), V219 (≠ L204), L294 (= L284), F302 (= F292), L354 (= L344), S380 (= S374), Q381 (≠ E375), A382 (≠ I376)
7s49A Crystal structure of inhibitor-bound galactokinase (see paper)
34% identity, 96% coverage: 6:379/388 of query aligns to 16:385/391 of 7s49A
- binding (4R)-2-[(1,3-benzoxazol-2-yl)amino]-4-(4-chloro-1H-pyrazol-5-yl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one: S78 (vs. gap), D82 (vs. gap), R104 (≠ L87), W105 (= W88), Y108 (= Y91), V128 (≠ F113), L134 (≠ I119), S140 (= S125), S141 (= S126), L144 (≠ I129), R227 (≠ P212)
- binding alpha-D-galactopyranose: E42 (= E32), H43 (= H33), D45 (= D35), Y46 (= Y36), G182 (= G167), D185 (= D170), Y235 (= Y220)
- binding phosphate ion: G135 (= G120), G137 (= G122), S139 (= S124), S140 (= S125), S141 (= S126), Q171 (≠ R156), H174 (≠ N159), H362 (≠ D352), H366 (≠ N356)
7rclA Crystal structure of adp-bound galactokinase (see paper)
34% identity, 96% coverage: 6:379/388 of query aligns to 16:385/391 of 7rclA
- binding adenosine-5'-diphosphate: T76 (vs. gap), S78 (vs. gap), W105 (= W88), Y108 (= Y91), G135 (= G120), G137 (= G122), S139 (= S124), S140 (= S125), S141 (= S126), L144 (≠ I129), H228 (≠ R213)
- binding alpha-D-galactopyranose: E42 (= E32), H43 (= H33), D45 (= D35), Y46 (= Y36), C181 (≠ S166), G182 (= G167), M184 (= M169), D185 (= D170), Y235 (= Y220)
- binding phosphate ion: H362 (≠ D352), H366 (≠ N356)
7ozxB Structure of human galactokinase 1 bound with azepan-1-yl(2,6- difluorophenyl)methanone
34% identity, 96% coverage: 6:379/388 of query aligns to 16:385/391 of 7ozxB
- binding beta-D-galactopyranose: E42 (= E32), H43 (= H33), D45 (= D35), Y46 (= Y36), G182 (= G167), M184 (= M169), D185 (= D170), Y235 (= Y220), G345 (≠ A335)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one: S78 (vs. gap), D82 (vs. gap), R104 (≠ L87), Y108 (= Y91), S130 (≠ G115), L134 (≠ I119), S140 (= S125), S141 (= S126), L144 (≠ I129)
- binding (azepan-1-yl)(2,6-difluorophenyl)methanone: S32 (≠ F22)
Sites not aligning to the query:
6zgyA Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide (see paper)
34% identity, 96% coverage: 6:379/388 of query aligns to 16:385/391 of 6zgyA
- binding beta-D-galactopyranose: E42 (= E32), H43 (= H33), D45 (= D35), Y46 (= Y36), G182 (= G167), M184 (= M169), D185 (= D170), Y235 (= Y220)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one: D82 (vs. gap), R104 (≠ L87), W105 (= W88), V128 (≠ F113), S130 (≠ G115), L134 (≠ I119), S140 (= S125), L144 (≠ I129)
- binding (2,5-dimethylphenyl) pyridine-4-carboxylate: L212 (≠ V197), D214 (≠ L199), L217 (≠ Y202), L294 (= L284), F302 (= F292), L354 (= L344)
6q91A Structure of human galactokinase 1 bound with 5-chloro-n-isobutyl-2- methoxybenzamide
34% identity, 96% coverage: 6:379/388 of query aligns to 17:386/392 of 6q91A
- binding beta-D-galactopyranose: E43 (= E32), H44 (= H33), D46 (= D35), Y47 (= Y36), C182 (≠ S166), G183 (= G167), M185 (= M169), D186 (= D170), Y236 (= Y220), G346 (≠ A335)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one: R105 (≠ L87), W106 (= W88), Y109 (= Y91), S131 (≠ G115), L135 (≠ I119), G136 (= G120), S141 (= S125)
- binding 5-chloranyl-2-methoxy-~{N}-(2-methylpropyl)benzamide: L213 (≠ V197), S214 (≠ D198), D215 (≠ L199), L218 (≠ Y202), L295 (= L284), G298 (= G287), D299 (≠ N288), Y300 (≠ L289), F303 (= F292), L355 (= L344)
6q3xA Structure of human galactokinase in complex with galactose and 2'- (benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'h-spiro[cyclohexane-1,4'- quinazolin]-5'(6'h)-one (see paper)
34% identity, 96% coverage: 6:379/388 of query aligns to 18:387/393 of 6q3xA
- binding beta-D-galactopyranose: E44 (= E32), H45 (= H33), D47 (= D35), G184 (= G167), M186 (= M169), D187 (= D170), Y237 (= Y220), G347 (≠ A335)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one: Y110 (= Y91), L136 (≠ I119), S142 (= S125), S143 (= S126), L146 (≠ I129)
1wuuA Crystal structure of human galactokinase complexed with mgamppnp and galactose (see paper)
35% identity, 96% coverage: 6:379/388 of query aligns to 18:385/391 of 1wuuA
- binding phosphoaminophosphonic acid-adenylate ester: T78 (vs. gap), S80 (vs. gap), W107 (= W88), Y110 (= Y91), L136 (≠ I119), G137 (= G120), G139 (= G122), S141 (= S124), S142 (= S125), S143 (= S126), L146 (≠ I129)
- binding alpha-D-galactopyranose: E44 (= E32), H45 (= H33), D47 (= D35), Y48 (= Y36), G184 (= G167), M186 (= M169), D187 (= D170), Y235 (= Y220)
6zh0A Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide (see paper)
34% identity, 96% coverage: 6:379/388 of query aligns to 16:384/390 of 6zh0A
- binding beta-D-galactopyranose: R36 (= R26), E42 (= E32), H43 (= H33), D45 (= D35), G182 (= G167), M184 (= M169), D185 (= D170), Y235 (= Y220), G345 (≠ A335)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one: D82 (vs. gap), R104 (≠ L87), W105 (= W88), L134 (≠ I119), S140 (= S125), L144 (≠ I129)
- binding N-(3-chlorophenyl)-2,2,2-trifluoroacetamide: L212 (≠ V197), L294 (= L284), G297 (= G287), D298 (≠ N288), Y299 (≠ L289), F302 (= F292), L354 (= L344)
6terA Crystal structure of a galactokinase from bifidobacterium infantis in complex with galactose (see paper)
36% identity, 93% coverage: 9:369/388 of query aligns to 23:400/418 of 6terA
- binding beta-D-galactopyranose: E46 (= E32), H47 (= H33), D49 (= D35), Y50 (= Y36), G188 (= G167), Y248 (= Y220), G367 (≠ A335)
- binding alpha-D-galactopyranose: E46 (= E32), H47 (= H33), D49 (= D35), Y50 (= Y36), G188 (= G167), D191 (= D170), Y248 (= Y220), G367 (≠ A335)
6teqA Crystal structure of a galactokinase from bifidobacterium infantis in complex with 2-deoxy-2-fluoro-galactose (see paper)
36% identity, 93% coverage: 9:369/388 of query aligns to 23:400/418 of 6teqA
- binding 2-deoxy-2-fluoro-beta-D-galactopyranose: E46 (= E32), H47 (= H33), D49 (= D35), Y50 (= Y36), G188 (= G167), L190 (≠ M169), D191 (= D170), Y248 (= Y220), G366 (= G334), G367 (≠ A335)
- binding 2-deoxy-2-fluoro-alpha-D-galactopyranose: E46 (= E32), H47 (= H33), D49 (= D35), Y50 (= Y36), G188 (= G167), L190 (≠ M169), D191 (= D170), Y248 (= Y220), G366 (= G334), G367 (≠ A335)
6q90C Structure of human galactokinase 1 bound with 1-(4-methoxyphenyl)-3- (4-pyridinyl)urea
34% identity, 96% coverage: 6:379/388 of query aligns to 17:385/391 of 6q90C
- binding beta-D-galactopyranose: E43 (= E32), H44 (= H33), D46 (= D35), Y47 (= Y36), G182 (= G167), D185 (= D170)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one: R104 (≠ L87), W105 (= W88), Y108 (= Y91), L134 (≠ I119), S140 (= S125), L144 (≠ I129)
- binding N-(4-methoxyphenyl)-N'-pyridin-4-ylurea: L212 (≠ V197), D214 (≠ L199), P215 (≠ G200), L217 (≠ Y202), L354 (= L344), Q381 (≠ E375)
6zfhA Structure of human galactokinase in complex with galactose and 2'- (benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'h-spiro[cyclopentane-1,4'- quinazolin]-5'(6'h)-one (see paper)
34% identity, 96% coverage: 6:379/388 of query aligns to 15:380/386 of 6zfhA
- binding beta-D-galactopyranose: E41 (= E32), H42 (= H33), D44 (= D35), G181 (= G167), M183 (= M169), D184 (= D170), Y230 (= Y220), G340 (≠ A335)
- binding 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclopentane]-5-one: W104 (= W88), Y107 (= Y91), L133 (≠ I119), S139 (= S125), S140 (= S126), L143 (≠ I129)
6gr2A Structure of human galactokinase in complex with galactose and adp
34% identity, 96% coverage: 6:379/388 of query aligns to 14:377/383 of 6gr2A
- binding adenosine-5'-diphosphate: T74 (vs. gap), S76 (vs. gap), Y106 (= Y91), L132 (≠ I119), G133 (= G120), G135 (= G122), S137 (= S124), S138 (= S125), S139 (= S126)
- binding beta-D-galactopyranose: E40 (= E32), H41 (= H33), D43 (= D35), G180 (= G167), D183 (= D170), Y227 (= Y220)
Query Sequence
>CA265_RS09565 FitnessBrowser__Pedo557:CA265_RS09565
MNINLQEKFAEQYHKKADAIYFTPGRVNLIGEHIDYNGGLVMPCAITLGTWVAIAPNNDN
LFRFKSLNFDVQTAVTSNTINEKDGSLWANYPVGVINEFIKDGKEINGLDFLFYGNIPIG
SGLSSSASIEIATAYALNTYINLGYDKLDLVKIAKRVENDFIGLNSGIMDQFAVAFGEKN
KAIVLDCETLKYKMVDVDLGNYVLAIINTNKPRELADSKYNERVAECQTALKLLNEEITL
HYLCELTAEKFALHSHLITDQTILNRATHVVKENDRVHLAAKALNGGNLAEFGRLMYASH
ESLRTLYEVSGKELDAVVDFCADYEHVIGARMTGAGFGGCAIALLEKGFEEDFAKNLTDY
YVEKIGYPAAIYISEIGNGPYLTTDPQR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory