SitesBLAST

P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
47% identity, 71% coverage: 52:197/207 of query aligns to 3:149/166 of P19921

query
sites
P19921

K

K

I

A

P

H

L

I

K

E

L

L

T

T

V

I

N

N

N

G

K

H

A

P

Y

V

Q

E

T

A

T

L

V

V

E

E

P

P

R

R

V

T

T

L

L

L

L

I

D

H

Y

F

L

I

R

R

E

E

E

Q

L

Q

H

N

L

L

T

T

G

G

T

A

K

H

K

I

G

G

C
|
C

D

D

H

T

G

S

Q

H

C
|
C

G

G

A

A

C
|
C

T

T

V

V

H

D

V

L

D

D

G

G

Q

M

R

S

V

V

N

K

S

S

C
|
C

L

T

S

M

L

F

A

A

V

V

M

Q

N

A

E

N

G

G

K

A

K

S

I

I

T

T

I

I

E

E

G

G

L

M

A

A

N

A

G

P

D

D

-

G

T

T

L

L

H

S

P

A

M

L

Q

Q

A

E

A

G

F

F

I

R

K

M

H

M

D

H

G

G

F

L

Q

Q

C
|
C

G

G

Y

Y

C
|
C

T

T

P

P

G

G

Q

M

I

I

M

M

S

R

A

S

V

H

A

R

C

L

V

L

R

Q

E

E

G

N

H

P

T

S

G

P

S

T

R

E

A

A

E

E

I

I

S

R

E

F

Y

G

M

I

S

G

G

G

N

N

I

L

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

Q

N

N

I

I

V

V

D

K

A

A

I

I

C42 (= C91) binding
C47 (= C96) binding
C50 (= C99) binding
C62 (= C111) binding
C102 (= C150) binding
C105 (= C153) binding
C137 (= C185) binding
C139 (= C187) binding

1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
47% identity, 71% coverage: 52:197/207 of query aligns to 1:147/161 of 1n5wA

query
sites
1n5wA

K

K

I

A

P

H

L

I

K

E

L

L

T

T

V

I

N

N

N

G

K

H

A

P

Y

V

Q

E

T

A

T

L

V

V

E

E

P

P

R

R

V

T

T

L

L

L

L

I

D

H

Y

F

L

I

R

R

E

E

E

Q

L

Q

H

N

L

L

T

T

G

G

T

A

K

H

K
x
I

G
|
G

C
|
C

D

D

H

T

G
x
S

Q
x
H

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

H

D

V

L

D

D

G

G

Q

M

R

S

V

V

N

K

S

S

C
|
C

L

T

S

M

L

F

A

A

V

V

M

Q

N

A

E

N

G

G

K

A

K

S

I

I

T

T

I

I

E

E

G

G

L

M

A

A

N

A

G

P

D

D

-

G

T

T

L

L

H

S

P

A

M

L

Q

Q

A

E

A

G

F

F

I

R

K

M

H

M

D

H

G

G

F

L

Q

Q

C
|
C

G
|
G

Y

Y

C
|
C

T

T

P

P

G

G

Q

M

I

I

M

M

S

R

A

S

V

H

A

R

C

L

V

L

R

Q

E

E

G

N

H

P

T

S

G

P

S

T

R

E

A

A

E

E

I

I

S

R

E

F

Y

G

M

I

S

G

G

G

N

N

I

L

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

Q

N

N

I

I

V

V

D

K

A

A

I

I

binding flavin-adenine dinucleotide: S43 (≠ G94), H44 (≠ Q95)
binding fe2/s2 (inorganic) cluster: I38 (≠ K89), G39 (= G90), C40 (= C91), S43 (≠ G94), C45 (= C96), G46 (= G97), C48 (= C99), C60 (= C111), C100 (= C150), G101 (= G151), C103 (= C153), C135 (= C185), C137 (= C187)

1n5wD Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
47% identity, 71% coverage: 52:197/207 of query aligns to 1:147/158 of 1n5wD

query
sites
1n5wD

K

K

I

A

P

H

L

I

K

E

L

L

T

T

V

I

N

N

N

G

K

H

A

P

Y

V

Q

E

T

A

T

L

V

V

E

E

P

P

R

R

V

T

T

L

L

L

L

I

D

H

Y

F

L

I

R

R

E

E

E

Q

L

Q

H

N

L

L

T

T

G

G

T

A

K

H

K

I

G

G

C
|
C

D

D

H

T

G
x
S

Q
x
H

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

H

D

V

L

D

D

G

G

Q

M

R

S

V

V

N

K

S

S

C
|
C

L

T

S

M

L

F

A

A

V

V

M

Q

N

A

E

N

G

G

K

A

K

S

I

I

T

T

I

I

E

E

G

G

L

M

A

A

N

A

G

P

D

D

-

G

T

T

L

L

H

S

P

A

M

L

Q

Q

A

E

A

G

F

F

I

R

K

M

H

M

D

H

G

G

F

L

Q
|
Q

C
|
C

G
|
G

Y

Y

C
|
C

T

T

P

P

G

G

Q

M

I

I

M

M

S

R

A

S

V

H

A

R

C

L

V

L

R

Q

E

E

G

N

H

P

T

S

G

P

S

T

R

E

A

A

E

E

I

I

S

R

E

F

Y

G

M

I

S

G

G

G

N

N

I

L

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

Q

N

N

I

I

V

V

D

K

A

A

I

I

binding flavin-adenine dinucleotide: S43 (≠ G94), H44 (≠ Q95)
binding fe2/s2 (inorganic) cluster: C40 (= C91), S43 (≠ G94), C45 (= C96), G46 (= G97), C48 (= C99), C60 (= C111), C100 (= C150), G101 (= G151), C103 (= C153), C135 (= C185), C137 (= C187)
binding pterin cytosine dinucleotide: Q99 (= Q149), C137 (= C187)

1dgjA Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
44% identity, 69% coverage: 57:199/207 of query aligns to 6:151/906 of 1dgjA

query
sites
1dgjA

L

L

T

I

V

V

N

N

N

G

K

M

A

A

Y

R

Q

R

T

L

V

V

E

S

P

P

R

N

V

D

T

L

L

L

L

V

D

D

Y

V

L

L

R

R

E

S

E

Q

L

L

H

Q

L

L

T

T

G

S

T

V

K

K

K
x
V

G
|
G

C
|
C

D
x
G

H

K

G
|
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

H

I

V

L

D

D

G

G

Q

K

R

V

V

V

N
x
R

S

A

C
|
C

L

I

-

I

S

K

L

M

A

S

V

R

M

V

N

A

E

E

G

N

K

A

K

S

I

V

T

T

I

L

E

E

G

G

L

I

A

G

N

A

G

P

D

D

T

C

L

L

H

H

P

P

M

L

Q

Q

A

H

A

A

F

W

I

I

K

Q

H

H

D

G

G

A

F

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

T

T

P

P

G

G

Q

F

I

I

M

V

S

S

A

A

V

K

A

A

C

L

V

L

R

D

E

E

G

N

H

V

T

A

G

P

S

S

R

R

A

E

E

D

I

V

S

R

E

D

Y

W

M

F

S

Q

G

K

-

H

N

N

I

I

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

K

N

P

I

L

V

V

D

D

A

A

I

V

I

M

E

D

binding fe2/s2 (inorganic) cluster: V38 (≠ K89), G39 (= G90), C40 (= C91), G41 (≠ D92), G43 (= G94), Q44 (= Q95), C45 (= C96), G46 (= G97), C48 (= C99), R58 (≠ N109), C60 (= C111), C100 (= C150), G101 (= G151), C103 (= C153), C137 (= C185), C139 (= C187)
binding pterin cytosine dinucleotide: Q99 (= Q149), C139 (= C187)

Sites not aligning to the query:

active site: 391, 427, 503, 507, 535, 869, 870
binding molybdenum (iv)oxide: 424, 535, 698, 869
binding pterin cytosine dinucleotide: 423, 424, 535, 652, 655, 656, 657, 658, 697, 698, 700, 702, 703, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

7dqxC Crystal structure of xanthine dehydrogenase family protein
45% identity, 70% coverage: 55:199/207 of query aligns to 6:151/160 of 7dqxC

query
sites
7dqxC

L

L

K

T

L

V

T

E

V

V

N

N

N

G

K

V

A

T

Y

H

Q

A

T

T

T

D

V

V

E

E

P

P

R

R

V

R

T

L

L

L

L

A

D

D

Y

F

L

L

R

R

E

D

L

L

H

H

L

L

T

R

G

G

T

T

K

R

K

V

G

G

C
|
C

D

E

H

H

G
|
G

Q
x
V

C
|
C

G

G

A

S

C
|
C

T

T

V

V

H

I

V

L

D

D

G

G

Q

Q

R

P

V

V

N
x
R

S

S

C
|
C

L

T

S

V

L

L

A

A

V

V

M

Q

N

A

E

N

G

N

K

S

K

R

I

I

T

E

T

T

I

V

E

E

G

S

L

L

A

Q

N

K

G

D

D

G

T

Q

L

L

H

H

P

P

M

L

Q

Q

A

R

A

S

F

F

I

S

K

K

H

C

D

H

G

A

F

L

Q
|
Q

C
|
C

G

G

Y

F

C
|
C

T

T

P

S

G

G

Q

F

I

L

M

M

S

T

A

L

V

K

A

P

C

L

V

Y

-

D

R

D

E

E

G

D

H

V

T

T

G

L

S

D

R

A

A

T

E

S

I

A

S

R

E

E

Y

A

M

I

S

S

G

G

N

N

I

L

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

Q

N

Q

I

I

V

V

D

E

A

A

I

T

I

V

E

D

binding fe2/s2 (inorganic) cluster: C42 (= C91), G45 (= G94), V46 (≠ Q95), C47 (= C96), C50 (= C99), R60 (≠ N109), C62 (= C111), Q100 (= Q149), C101 (= C150), C104 (= C153), C137 (= C185), C139 (= C187)
binding pterin cytosine dinucleotide: Q100 (= Q149), C139 (= C187)

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
40% identity, 69% coverage: 57:199/207 of query aligns to 6:151/907 of 4usaA

query
sites
4usaA

L

I

T

T

V

V

N

N

N

G

K

I

A

E

Y

Q

Q

N

T

L

T

F

V

V

E

D

P

A

R

E

V

A

T

L

L

L

L

S

D

D

Y

V

L

L

R

R

E

Q

L

L

H

G

L

L

T

T

G

G

T

V

K

K

K
x
V

G

G

C
|
C

D
x
E

H

Q

G
|
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

V

L

D

D

G

G

Q

K

R

V

V

V

N
x
R

S

A

C
|
C

L

V

S

T

-

K

L

M

A

K

V

R

M

V

N

A

E

D

G

G

K

A

K

Q

I

I

T

T

I

I

E

E

G

G

L

V

A

G

N

Q

G

P

D

E

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

I

V

K

L

H

H

D

G

G

G

F

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

T

S

P

P

G

G

Q

F

I

I

M

V

S

S

A

A

V

K

A

G

C

L

V

L

R

D

E

T

G

N

H

A

T

D

G

P

S

S

R

R

A

E

E

D

I

V

S

R

E

D

Y

W

M

F

S

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

K

N

P

I

L

V

V

D

D

A

A

I

V

I

M

E

D

binding fe2/s2 (inorganic) cluster: V38 (≠ K89), C40 (= C91), E41 (≠ D92), G43 (= G94), C45 (= C96), G46 (= G97), C48 (= C99), R58 (≠ N109), C60 (= C111), C100 (= C150), G101 (= G151), C103 (= C153), C137 (= C185), C139 (= C187)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q149), C139 (= C187)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 531, 532, 535, 539
binding hydrocinnamic acid: 255, 425, 494, 497, 535, 626
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
40% identity, 69% coverage: 57:199/207 of query aligns to 6:151/907 of 4us9A

query
sites
4us9A

L

I

T

T

V

V

N

N

N

G

K

I

A

E

Y

Q

Q

N

T

L

T

F

V

V

E

D

P

A

R

E

V

A

T

L

L

L

L

S

D

D

Y

V

L

L

R

R

E

Q

L

L

H

G

L

L

T

T

G

G

T

V

K

K

K
x
V

G

G

C
|
C

D
x
E

H

Q

G
|
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

V

L

D

D

G

G

Q

K

R

V

V

V

N
x
R

S

A

C
|
C

L

V

S

T

-

K

L

M

A

K

V

R

M

V

N

A

E

D

G

G

K

A

K

Q

I

I

T

T

I

I

E

E

G

G

L

V

A

G

N

Q

G

P

D

E

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

I

V

K

L

H

H

D

G

G

G

F

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

T

S

P

P

G

G

Q

F

I

I

M

V

S

S

A

A

V

K

A

G

C

L

V

L

R

D

E

T

G

N

H

A

T

D

G

P

S

S

R

R

A

E

E

D

I

V

S

R

E

D

Y

W

M

F

S

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

K

N

P

I

L

V

V

D

D

A

A

I

V

I

M

E

D

binding fe2/s2 (inorganic) cluster: V38 (≠ K89), C40 (= C91), E41 (≠ D92), G43 (= G94), C45 (= C96), G46 (= G97), C48 (= C99), R58 (≠ N109), C60 (= C111), C100 (= C150), G101 (= G151), C103 (= C153), C137 (= C185), C139 (= C187)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q149), C139 (= C187)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 3-phenylpropanal: 255, 257, 258, 752
binding bicarbonate ion: 460, 498, 531, 532, 535, 539, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
40% identity, 69% coverage: 57:199/207 of query aligns to 6:151/907 of 4us8A

query
sites
4us8A

L

I

T

T

V

V

N

N

N

G

K

I

A

E

Y

Q

Q

N

T

L

T

F

V

V

E

D

P

A

R

E

V

A

T

L

L

L

L

S

D

D

Y

V

L

L

R

R

E

Q

L

L

H

G

L

L

T

T

G

G

T

V

K

K

K
x
V

G

G

C
|
C

D
x
E

H

Q

G
|
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

V

L

D

D

G

G

Q

K

R

V

V

V

N
x
R

S

A

C
|
C

L

V

S

T

-

K

L

M

A

K

V

R

M

V

N

A

E

D

G

G

K

A

K

Q

I

I

T

T

I

I

E

E

G

G

L

V

A

G

N

Q

G

P

D

E

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

I

V

K

L

H

H

D

G

G

G

F

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

T

S

P

P

G

G

Q

F

I

I

M

V

S

S

A

A

V

K

A

G

C

L

V

L

R

D

E

T

G

N

H

A

T

D

G

P

S

S

R

R

A

E

E

D

I

V

S

R

E

D

Y

W

M

F

S

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

K

N

P

I

L

V

V

D

D

A

A

I

V

I

M

E

D

binding fe2/s2 (inorganic) cluster: V38 (≠ K89), C40 (= C91), E41 (≠ D92), G43 (= G94), C45 (= C96), G46 (= G97), C48 (= C99), R58 (≠ N109), C60 (= C111), C100 (= C150), G101 (= G151), C103 (= C153), C137 (= C185), C139 (= C187)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q149), C139 (= C187)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 532, 535, 539
binding benzaldehyde: 255, 255, 394, 425, 425, 425, 425, 497, 497, 501, 531, 535, 535, 626, 626, 626, 694, 696, 697
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
40% identity, 69% coverage: 57:199/207 of query aligns to 6:151/907 of 4c7yA

query
sites
4c7yA

L

I

T

T

V

V

N

N

N

G

K

I

A

E

Y

Q

Q

N

T

L

T

F

V

V

E

D

P

A

R

E

V

A

T

L

L

L

L

S

D

D

Y

V

L

L

R

R

E

Q

L

L

H

G

L

L

T

T

G

G

T

V

K

K

K

V

G

G

C
|
C

D
x
E

H

Q

G
|
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

V

L

D

D

G

G

Q

K

R

V

V

V

N
x
R

S

A

C
|
C

L

V

S

T

-

K

L

M

A

K

V

R

M

V

N

A

E

D

G

G

K

A

K

Q

I

I

T

T

I

I

E

E

G

G

L

V

A

G

N

Q

G

P

D

E

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

I

V

K

L

H

H

D

G

G

G

F

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

T

S

P

P

G

G

Q

F

I

I

M

V

S

S

A

A

V

K

A

G

C

L

V

L

R

D

E

T

G

N

H

A

T

D

G

P

S

S

R

R

A

E

E

D

I

V

S

R

E

D

Y

W

M

F

S

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

K

N

P

I

L

V

V

D

D

A

A

I

V

I

M

E

D

binding fe2/s2 (inorganic) cluster: C40 (= C91), E41 (≠ D92), G43 (= G94), C45 (= C96), G46 (= G97), C48 (= C99), R58 (≠ N109), C60 (= C111), C100 (= C150), G101 (= G151), C103 (= C153), C137 (= C185), C139 (= C187)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q149), C139 (= C187)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 535, 539
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869
binding hydrogen peroxide: 696, 697, 869

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
40% identity, 69% coverage: 57:199/207 of query aligns to 6:151/907 of 3fc4A

query
sites
3fc4A

L

I

T

T

V

V

N

N

N

G

K

I

A

E

Y

Q

Q

N

T

L

T

F

V

V

E

D

P

A

R

E

V

A

T

L

L

L

L

S

D

D

Y

V

L

L

R

R

E

Q

L

L

H

G

L

L

T

T

G

G

T

V

K

K

K
x
V

G

G

C
|
C

D
x
E

H

Q

G
|
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

V

L

D

D

G

G

Q

K

R

V

V

V

N
x
R

S

A

C
|
C

L

V

S

T

-

K

L

M

A

K

V

R

M

V

N

A

E

D

G

G

K

A

K

Q

I

I

T

T

I

I

E

E

G

G

L

V

A

G

N

Q

G

P

D

E

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

I

V

K

L

H

H

D

G

G

G

F

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

T

S

P

P

G

G

Q

F

I

I

M

V

S

S

A

A

V

K

A

G

C

L

V

L

R

D

E

T

G

N

H

A

T

D

G

P

S

S

R

R

A

E

E

D

I

V

S

R

E

D

Y

W

M

F

S

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

K

N

P

I

L

V

V

D

D

A

A

I

V

I

M

E

D

binding fe2/s2 (inorganic) cluster: V38 (≠ K89), C40 (= C91), E41 (≠ D92), G43 (= G94), C45 (= C96), G46 (= G97), C48 (= C99), R58 (≠ N109), C60 (= C111), C100 (= C150), G101 (= G151), C103 (= C153), C137 (= C185), C139 (= C187)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q149), C139 (= C187)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 1,2-ethanediol: 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

3fahA Glycerol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
40% identity, 69% coverage: 57:199/207 of query aligns to 6:151/907 of 3fahA

query
sites
3fahA

L

I

T

T

V

V

N

N

N

G

K

I

A

E

Y

Q

Q

N

T

L

T

F

V

V

E

D

P

A

R

E

V

A

T

L

L

L

L

S

D

D

Y

V

L

L

R

R

E

Q

L

L

H

G

L

L

T

T

G

G

T

V

K

K

K
x
V

G

G

C
|
C

D
x
E

H

Q

G
|
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

V

L

D

D

G

G

Q

K

R

V

V

V

N
x
R

S

A

C
|
C

L

V

S

T

-

K

L

M

A

K

V

R

M

V

N

A

E

D

G

G

K

A

K

Q

I

I

T

T

I

I

E

E

G

G

L

V

A

G

N

Q

G

P

D

E

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

I

V

K

L

H

H

D

G

G

G

F

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

T

S

P

P

G

G

Q

F

I

I

M

V

S

S

A

A

V

K

A

G

C

L

V

L

R

D

E

T

G

N

H

A

T

D

G

P

S

S

R

R

A

E

E

D

I

V

S

R

E

D

Y

W

M

F

S

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

K

N

P

I

L

V

V

D

D

A

A

I

V

I

M

E

D

binding fe2/s2 (inorganic) cluster: V38 (≠ K89), C40 (= C91), E41 (≠ D92), G43 (= G94), C45 (= C96), G46 (= G97), C48 (= C99), R58 (≠ N109), C60 (= C111), C100 (= C150), G101 (= G151), C103 (= C153), C137 (= C185), C139 (= C187)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q149), C139 (= C187)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding glycerol: 416, 535, 622, 683, 696, 697, 869, 884, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

1sijA Crystal structure of the aldehyde dehydrogenase (a.K.A. Aor or mop) of desulfovibrio gigas covalently bound to [aso3]- (see paper)
40% identity, 69% coverage: 57:199/207 of query aligns to 6:151/907 of 1sijA

query
sites
1sijA

L

I

T

T

V

V

N

N

N

G

K

I

A

E

Y

Q

Q

N

T

L

T

F

V

V

E

D

P

A

R

E

V

A

T

L

L

L

L

S

D

D

Y

V

L

L

R

R

E

Q

L

L

H

G

L

L

T

T

G

G

T

V

K

K

K
x
V

G

G

C
|
C

D
x
E

H

Q

G
|
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

V

L

D

D

G

G

Q

K

R

V

V

V

N
x
R

S

A

C
|
C

L

V

S

T

-

K

L

M

A

K

V

R

M

V

N

A

E

D

G

G

K

A

K

Q

I

I

T

T

I

I

E

E

G

G

L

V

A

G

N

Q

G

P

D

E

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

I

V

K

L

H

H

D

G

G

G

F

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

T

S

P

P

G

G

Q

F

I

I

M

V

S

S

A

A

V

K

A

G

C

L

V

L

R

D

E

T

G

N

H

A

T

D

G

P

S

S

R

R

A

E

E

D

I

V

S

R

E

D

Y

W

M

F

S

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R

R

C
|
C

G

T

A

G

Y

Y

P

K

N

P

I

L

V

V

D

D

A

A

I

V

I

M

E

D

binding fe2/s2 (inorganic) cluster: V38 (≠ K89), C40 (= C91), E41 (≠ D92), G43 (= G94), C45 (= C96), G46 (= G97), C48 (= C99), R58 (≠ N109), C60 (= C111), Q99 (= Q149), C100 (= C150), G101 (= G151), C103 (= C153), C137 (= C185), C139 (= C187)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q149), C139 (= C187)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding arsenite: 535, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 653, 654, 655, 656, 695, 696, 698, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

Query Sequence

>CA265_RS09870 FitnessBrowser__Pedo557:CA265_RS09870
MKSSDQKPNQGDSRRDFLKKSSVITAIALTPGVAVKAAESNADERFAELFEKIPLKLTVN
NKAYQTTVEPRVTLLDYLREELHLTGTKKGCDHGQCGACTVHVDGQRVNSCLSLAVMNEG
KKITTIEGLANGDTLHPMQAAFIKHDGFQCGYCTPGQIMSAVACVREGHTGSRAEISEYM
SGNICRCGAYPNIVDAIIEVKEGGETV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory