SitesBLAST
Comparing CCNA_00397 FitnessBrowser__Caulo:CCNA_00397 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7orxCCC jostii RHA1 thiamine diphosphate-dependent 4-hydroxybenzoylformate decarboxylase
28% identity, 97% coverage: 15:509/512 of query aligns to 19:523/531 of 7orxCCC
- active site: N26 (= N22), G28 (= G24), S29 (≠ T25), N30 (≠ S26), E31 (= E27), E50 (= E48), H73 (= H71), M112 (≠ P110), L113 (= L111), S114 (vs. gap), N115 (= N112), Y163 (≠ A160), P257 (vs. gap), H284 (≠ Y279), S379 (≠ A358), G404 (= G383), L406 (≠ I385), D431 (= D410), N458 (= N437), T460 (≠ A439), Y461 (= Y440), A463 (≠ I442), L464 (= L443), F467 (≠ I445)
- binding thiamine diphosphate: N26 (= N22), P27 (= P23), S29 (≠ T25), E50 (= E48), H73 (= H71), S76 (≠ P74), G77 (= G75), S379 (≠ A358), T380 (≠ V359), S381 (≠ T360), G404 (= G383), G405 (≠ A384), L406 (≠ I385), G430 (= G409), D431 (= D410), G432 (= G411), S433 (≠ A412), Y436 (= Y415), N458 (= N437), T460 (≠ A439), Y461 (= Y440), G462 (≠ R441), A463 (≠ I442), L464 (= L443)
6qsiA Pseudomonas fluorescens pf-5 thiamine diphosphate-dependent 4- hydroxybenzoylformate decarboxylase (see paper)
27% identity, 97% coverage: 11:509/512 of query aligns to 11:519/525 of 6qsiA
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), E27 (= E27), E46 (= E48), H69 (= H71), M108 (≠ P110), L109 (= L111), A110 (vs. gap), Y159 (≠ A160), P253 (≠ L256), H280 (≠ Y279), S375 (≠ A358), G400 (= G383), L402 (≠ I385), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ G451)
- binding thiamine diphosphate: N22 (= N22), P23 (= P23), E46 (= E48), H69 (= H71), S375 (≠ A358), T376 (≠ V359), S377 (≠ T360), G400 (= G383), G401 (≠ A384), L402 (≠ I385), G426 (= G409), D427 (= D410), G428 (= G411), S429 (≠ A412), Y432 (= Y415), N454 (= N437), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443)
4q9dB X-ray structure of a putative thiamin diphosphate-dependent enzyme isolated from mycobacterium smegmatis (see paper)
26% identity, 98% coverage: 5:508/512 of query aligns to 7:513/519 of 4q9dB
- active site: N24 (= N22), G26 (= G24), S27 (≠ T25), T28 (≠ S26), E29 (= E27), Q47 (≠ F47), E48 (= E48), H71 (= H71), V107 (≠ F107), D108 (= D108), Y110 (≠ P110), L111 (= L111), N112 (= N112), N113 (≠ S113), L161 (≠ A160), P252 (≠ A255), Y279 (= Y279), M374 (≠ D356), S376 (≠ A358), G401 (= G383), I403 (= I385), D432 (= D410), N459 (= N437), E461 (≠ A439), Y462 (= Y440), I464 (= I442)
- binding magnesium ion: D432 (= D410), N459 (= N437), E461 (≠ A439)
Sites not aligning to the query:
6a50A Structure of benzoylformate decarboxylases in complex with cofactor tpp
26% identity, 98% coverage: 11:511/512 of query aligns to 12:522/527 of 6a50A
- binding magnesium ion: N117 (≠ A117), L118 (= L118), R120 (≠ A120), D428 (= D410), N455 (= N437), T457 (≠ A439)
- binding thiamine diphosphate: N23 (= N22), P24 (= P23), E47 (= E48), H70 (= H71), A73 (≠ P74), G74 (= G75), N77 (= N78), S376 (≠ A358), T377 (≠ V359), S378 (≠ T360), G401 (= G383), G402 (≠ A384), L403 (≠ I385), G427 (= G409), D428 (= D410), G429 (= G411), S430 (≠ A412), Y433 (= Y415), N455 (= N437), T457 (≠ A439), Y458 (= Y440), G459 (≠ R441), M460 (≠ I442), L461 (= L443)
3fznA Intermediate analogue in benzoylformate decarboxylase (see paper)
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/523 of 3fznA
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), E27 (= E27), E46 (= E48), H69 (= H71), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), Y159 (≠ A160), P253 (vs. gap), H280 (≠ A278), S375 (≠ A358), G400 (= G383), L402 (≠ I385), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: N22 (= N22), P23 (= P23), G24 (= G24), S25 (≠ T25), E46 (= E48), H69 (= H71), A72 (≠ P74), G73 (= G75), L109 (= L111), H280 (≠ A278), S375 (≠ A358), T376 (≠ V359), S377 (≠ T360), F396 (≠ S379), G400 (= G383), L402 (≠ I385), G426 (= G409), D427 (= D410), G428 (= G411), S429 (≠ A412), Y432 (= Y415), N454 (= N437), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
- binding magnesium ion: D427 (= D410), N454 (= N437), T456 (≠ A439)
- binding phosphate ion: Q286 (≠ S284), L288 (= L286), K289 (≠ V287), P290 (= P288)
1bfdA Benzoylformate decarboxylase from pseudomonas putida (see paper)
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/523 of 1bfdA
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), E27 (= E27), E46 (= E48), H69 (= H71), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), Y159 (≠ A160), P253 (vs. gap), H280 (≠ A278), S375 (≠ A358), G400 (= G383), L402 (≠ I385), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
- binding calcium ion: D427 (= D410), N454 (= N437), T456 (≠ A439)
- binding magnesium ion: N116 (≠ A117), L117 (= L118), R119 (≠ A120)
- binding thiamine diphosphate: S375 (≠ A358), T376 (≠ V359), S377 (≠ T360), G400 (= G383), G401 (≠ A384), L402 (≠ I385), G426 (= G409), D427 (= D410), G428 (= G411), S429 (≠ A412), Y432 (= Y415), N454 (= N437), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443)
5deiA Benzoylformate decarboxylase from pseudomonas putida
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/524 of 5deiA
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), E27 (= E27), E46 (= E48), H69 (= H71), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), Y159 (≠ A160), P253 (vs. gap), H280 (≠ A278), S375 (≠ A358), G400 (= G383), L402 (≠ I385), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
- binding bicarbonate ion: G24 (= G24), S25 (≠ T25), H69 (= H71), L109 (= L111), H280 (≠ A278), F463 (≠ E446)
- binding calcium ion: N185 (≠ D183), D186 (≠ A184), D427 (= D410), N454 (= N437), T456 (≠ A439)
- binding magnesium ion: N116 (≠ A117), L117 (= L118), R119 (≠ A120)
- binding thiamine diphosphate: N22 (= N22), P23 (= P23), E46 (= E48), H69 (= H71), A72 (≠ P74), G73 (= G75), S375 (≠ A358), T376 (≠ V359), S377 (≠ T360), G400 (= G383), G401 (≠ A384), L402 (≠ I385), G426 (= G409), D427 (= D410), G428 (= G411), S429 (≠ A412), Y432 (= Y415), N454 (= N437), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443)
Sites not aligning to the query:
3fsjX Crystal structure of benzoylformate decarboxylase in complex with the inhibitor mbp (see paper)
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/524 of 3fsjX