SitesBLAST
Comparing CCNA_00397 FitnessBrowser__Caulo:CCNA_00397 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7orxCCC jostii RHA1 thiamine diphosphate-dependent 4-hydroxybenzoylformate decarboxylase
28% identity, 97% coverage: 15:509/512 of query aligns to 19:523/531 of 7orxCCC
- active site: N26 (= N22), G28 (= G24), S29 (≠ T25), N30 (≠ S26), E31 (= E27), E50 (= E48), H73 (= H71), M112 (≠ P110), L113 (= L111), S114 (vs. gap), N115 (= N112), Y163 (≠ A160), P257 (vs. gap), H284 (≠ Y279), S379 (≠ A358), G404 (= G383), L406 (≠ I385), D431 (= D410), N458 (= N437), T460 (≠ A439), Y461 (= Y440), A463 (≠ I442), L464 (= L443), F467 (≠ I445)
- binding thiamine diphosphate: N26 (= N22), S29 (≠ T25), E50 (= E48), H73 (= H71), T380 (≠ V359), S381 (≠ T360), G404 (= G383), L406 (≠ I385), G430 (= G409), G432 (= G411), S433 (≠ A412), Y436 (= Y415), N458 (= N437), T460 (≠ A439), Y461 (= Y440), G462 (≠ R441)
6qsiA Pseudomonas fluorescens pf-5 thiamine diphosphate-dependent 4- hydroxybenzoylformate decarboxylase (see paper)
27% identity, 97% coverage: 11:509/512 of query aligns to 11:519/525 of 6qsiA
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), E27 (= E27), E46 (= E48), H69 (= H71), M108 (≠ P110), L109 (= L111), A110 (vs. gap), Y159 (≠ A160), P253 (≠ L256), H280 (≠ Y279), S375 (≠ A358), G400 (= G383), L402 (≠ I385), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ G451)
- binding thiamine diphosphate: N22 (= N22), P23 (= P23), E46 (= E48), H69 (= H71), T376 (≠ V359), S377 (≠ T360), L402 (≠ I385), G426 (= G409), G428 (= G411), S429 (≠ A412), Y432 (= Y415), N454 (= N437), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443)
4q9dB X-ray structure of a putative thiamin diphosphate-dependent enzyme isolated from mycobacterium smegmatis (see paper)
26% identity, 98% coverage: 5:508/512 of query aligns to 7:513/519 of 4q9dB
- active site: N24 (= N22), G26 (= G24), S27 (≠ T25), T28 (≠ S26), E29 (= E27), Q47 (≠ F47), E48 (= E48), H71 (= H71), V107 (≠ F107), D108 (= D108), Y110 (≠ P110), L111 (= L111), N112 (= N112), N113 (≠ S113), L161 (≠ A160), P252 (≠ A255), Y279 (= Y279), M374 (≠ D356), S376 (≠ A358), G401 (= G383), I403 (= I385), D432 (= D410), N459 (= N437), E461 (≠ A439), Y462 (= Y440), I464 (= I442)
- binding magnesium ion: D432 (= D410), N459 (= N437), E461 (≠ A439)
Sites not aligning to the query:
6a50A Structure of benzoylformate decarboxylases in complex with cofactor tpp
26% identity, 98% coverage: 11:511/512 of query aligns to 12:522/527 of 6a50A
- binding magnesium ion: N117 (≠ A117), L118 (= L118), R120 (≠ A120), D428 (= D410), N455 (= N437), T457 (≠ A439)
- binding thiamine diphosphate: N23 (= N22), P24 (= P23), E47 (= E48), H70 (= H71), T377 (≠ V359), S378 (≠ T360), G401 (= G383), L403 (≠ I385), G427 (= G409), D428 (= D410), G429 (= G411), S430 (≠ A412), Y433 (= Y415), N455 (= N437), T457 (≠ A439), Y458 (= Y440), G459 (≠ R441), M460 (≠ I442), L461 (= L443)
3fznA Intermediate analogue in benzoylformate decarboxylase (see paper)
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/523 of 3fznA
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), E27 (= E27), E46 (= E48), H69 (= H71), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), Y159 (≠ A160), P253 (vs. gap), H280 (≠ A278), S375 (≠ A358), G400 (= G383), L402 (≠ I385), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: N22 (= N22), P23 (= P23), G24 (= G24), S25 (≠ T25), E46 (= E48), H69 (= H71), H280 (≠ A278), T376 (≠ V359), S377 (≠ T360), G400 (= G383), L402 (≠ I385), G426 (= G409), D427 (= D410), G428 (= G411), S429 (≠ A412), Y432 (= Y415), N454 (= N437), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442)
- binding magnesium ion: D427 (= D410), N454 (= N437), T456 (≠ A439)
- binding phosphate ion: Q286 (≠ S284), L288 (= L286), K289 (≠ V287), P290 (= P288)
1bfdA Benzoylformate decarboxylase from pseudomonas putida (see paper)
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/523 of 1bfdA
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), E27 (= E27), E46 (= E48), H69 (= H71), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), Y159 (≠ A160), P253 (vs. gap), H280 (≠ A278), S375 (≠ A358), G400 (= G383), L402 (≠ I385), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
- binding calcium ion: D427 (= D410), N454 (= N437), T456 (≠ A439)
- binding magnesium ion: N116 (≠ A117), L117 (= L118), R119 (≠ A120)
- binding thiamine diphosphate: T376 (≠ V359), S377 (≠ T360), L402 (≠ I385), G426 (= G409), D427 (= D410), G428 (= G411), S429 (≠ A412), Y432 (= Y415), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443)
5deiA Benzoylformate decarboxylase from pseudomonas putida
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/524 of 5deiA
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), E27 (= E27), E46 (= E48), H69 (= H71), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), Y159 (≠ A160), P253 (vs. gap), H280 (≠ A278), S375 (≠ A358), G400 (= G383), L402 (≠ I385), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
- binding bicarbonate ion: S25 (≠ T25), H69 (= H71), L109 (= L111)
- binding calcium ion: N185 (≠ D183), D186 (≠ A184), D427 (= D410), N454 (= N437), T456 (≠ A439)
- binding magnesium ion: N116 (≠ A117), L117 (= L118), R119 (≠ A120)
- binding thiamine diphosphate: N22 (= N22), P23 (= P23), E46 (= E48), H69 (= H71), T376 (≠ V359), S377 (≠ T360), L402 (≠ I385), G426 (= G409), D427 (= D410), G428 (= G411), S429 (≠ A412), Y432 (= Y415), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443)
Sites not aligning to the query:
3fsjX Crystal structure of benzoylformate decarboxylase in complex with the inhibitor mbp (see paper)
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/524 of 3fsjX
- active site: G24 (= G24), S25 (≠ T25), E27 (= E27), E46 (= E48), H69 (= H71), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), H280 (≠ A278), G400 (= G383), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443)
- binding calcium ion: D427 (= D410), N454 (= N437), T456 (≠ A439)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: H280 (≠ A278), T376 (≠ V359), S377 (≠ T360), F396 (≠ S379), G400 (= G383), L402 (≠ I385), G426 (= G409), D427 (= D410), G428 (= G411), S429 (≠ A412), Y432 (= Y415), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
Sites not aligning to the query:
1mczA Benzoylformate decarboxylase from pseudomonas putida complexed with an inhibitor, r-mandelate (see paper)
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/524 of 1mczA
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), E27 (= E27), E46 (= E48), H69 (= H71), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), Y159 (≠ A160), P253 (vs. gap), H280 (≠ A278), S375 (≠ A358), G400 (= G383), L402 (≠ I385), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
- binding magnesium ion: N116 (≠ A117), L117 (= L118), R119 (≠ A120), D427 (= D410), N454 (= N437), T456 (≠ A439)
- binding (r)-mandelic acid: S25 (≠ T25), H69 (= H71), L109 (= L111), H280 (≠ A278), T376 (≠ V359), F463 (≠ E446)
- binding thiamine diphosphate: N22 (= N22), P23 (= P23), E46 (= E48), H69 (= H71), T376 (≠ V359), S377 (≠ T360), G400 (= G383), L402 (≠ I385), G426 (= G409), D427 (= D410), G428 (= G411), S429 (≠ A412), Y432 (= Y415), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443)
Sites not aligning to the query:
3f6bX Crystal structure of benzoylformate decarboxylase in complex with the pyridyl inhibitor paa (see paper)
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/525 of 3f6bX
- active site: G24 (= G24), E46 (= E48), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), G400 (= G383), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-2-[(1S,2E)-1-hydroxy-3-pyridin-3-ylprop-2-en-1-yl]-4-methyl-1,3-thiazol-3-ium: N22 (= N22), P23 (= P23), G24 (= G24), S25 (≠ T25), E46 (= E48), H69 (= H71)
Sites not aligning to the query:
1pi3A E28q mutant benzoylformate decarboxylase from pseudomonas putida
26% identity, 98% coverage: 11:511/512 of query aligns to 11:521/523 of 1pi3A
- active site: N22 (= N22), G24 (= G24), S25 (≠ T25), N26 (≠ S26), Q27 (≠ E27), E46 (= E48), H69 (= H71), L108 (≠ P110), L109 (= L111), T110 (vs. gap), N111 (= N112), Y159 (≠ A160), P253 (vs. gap), H280 (≠ A278), S375 (≠ A358), G400 (= G383), L402 (≠ I385), D427 (= D410), N454 (= N437), T456 (≠ A439), Y457 (= Y440), A459 (≠ I442), L460 (= L443), F463 (≠ E446)
- binding calcium ion: D427 (= D410), N454 (= N437), T456 (≠ A439)
- binding magnesium ion: N116 (≠ A117), L117 (= L118), R119 (≠ A120)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: T376 (≠ V359), S377 (≠ T360), L402 (≠ I385), G426 (= G409), G428 (= G411), S429 (≠ A412), Y432 (= Y415), N454 (= N437), T456 (≠ A439), Y457 (= Y440), G458 (≠ R441), A459 (≠ I442), L460 (= L443)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
25% identity, 99% coverage: 1:509/512 of query aligns to 6:516/539 of 6lpiB
- active site: I27 (≠ N22), G29 (= G24), G30 (≠ T25), S31 (= S26), I32 (≠ E27), E53 (= E48), C76 (≠ H71), F115 (≠ P110), Q116 (≠ L111), E117 (≠ N112), K165 (≠ A160), M256 (≠ L256), A283 (≠ P283), V375 (≠ A358), G401 (= G383), M403 (≠ I385), D428 (= D410), N455 (= N437), A457 (vs. gap), L458 (vs. gap), L460 (vs. gap), V461 (vs. gap), Q464 (≠ Y440)
- binding flavin-adenine dinucleotide: R155 (≠ T149), G212 (= G205), G213 (≠ S206), G214 (= G207), T236 (≠ A234), L237 (≠ R235), M238 (≠ Q236), L254 (= L254), M256 (≠ L256), H257 (≠ K257), G276 (≠ F276), A277 (≠ F277), R278 (≠ A278), D280 (≠ P280), R282 (= R282), A283 (≠ P283), D300 (≠ E300), I301 (≠ V301), D319 (≠ L310), V320 (≠ A311), M380 (≠ L363), G398 (≠ T381)
- binding magnesium ion: D428 (= D410), N455 (= N437)
- binding thiamine diphosphate: E53 (= E48), C76 (≠ H71), P79 (= P74), G376 (≠ V359), Q377 (≠ T360), H378 (≠ A361), G401 (= G383), M403 (≠ I385), G427 (= G409), D428 (= D410), G429 (= G411), S430 (≠ A412), M433 (≠ Y415), N455 (= N437), A457 (vs. gap), L458 (vs. gap), G459 (vs. gap), L460 (vs. gap), V461 (vs. gap)
5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
26% identity, 99% coverage: 2:508/512 of query aligns to 6:529/548 of 5d6rB
- active site: I26 (≠ N22), G28 (= G24), A29 (≠ T25), K30 (≠ S26), I31 (vs. gap), E51 (= E48), T74 (≠ H71), H113 (≠ P110), Q114 (≠ L111), S115 (≠ N112), Q163 (≠ A160), L254 (≠ Y250), E281 (≠ F277), M386 (≠ L363), Q412 (≠ G383), M414 (≠ I385), D439 (= D410), D466 (≠ N437), G468 (≠ A439), Y469 (= Y440), M471 (≠ I442), V472 (≠ L443), Q475 (≠ E446)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(Z)-2-fluoro-1-hydroxy-2-phosphonoethenyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: M386 (≠ L363), G387 (≠ P364), S388 (≠ I365), Q412 (≠ G383), M414 (≠ I385), D439 (= D410), G440 (= G411), G468 (≠ A439), Y469 (= Y440), N470 (≠ R441), M471 (≠ I442)
- binding magnesium ion: R63 (= R60), Q212 (≠ G210), D439 (= D410), D466 (≠ N437), G468 (≠ A439)
Sites not aligning to the query:
1ozfA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors (see paper)
26% identity, 99% coverage: 2:508/512 of query aligns to 6:528/545 of 1ozfA
- active site: I26 (≠ N22), G28 (= G24), A29 (≠ T25), K30 (≠ S26), I31 (vs. gap), E51 (= E48), T74 (≠ H71), H113 (≠ P110), Q114 (≠ L111), S115 (≠ N112), Q163 (≠ A160), L253 (≠ Y250), E280 (≠ F277), M385 (≠ L363), Q411 (≠ G383), M413 (≠ I385), D438 (= D410), D465 (≠ N437), G467 (≠ A439), Y468 (= Y440), M470 (≠ I442), V471 (≠ L443), Q474 (≠ E446)
- binding magnesium ion: D438 (= D410), D465 (≠ N437), G467 (≠ A439)
- binding phosphate ion: G249 (≠ D246), R250 (≠ K247), Q257 (≠ L254), R343 (vs. gap), R394 (≠ T367), L396 (≠ T369), Y397 (≠ K370)
- binding thiamine diphosphate: G386 (≠ P364), S387 (≠ I365), F388 (= F366), Q411 (≠ G383), M413 (≠ I385), G437 (= G409), D438 (= D410), G439 (= G411), D465 (≠ N437), G467 (≠ A439), Y468 (= Y440), N469 (≠ R441), M470 (≠ I442), V471 (≠ L443)
Sites not aligning to the query:
5dx6A Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
26% identity, 99% coverage: 2:508/512 of query aligns to 7:524/541 of 5dx6A
- active site: I27 (≠ N22), G29 (= G24), A30 (≠ T25), K31 (≠ S26), I32 (vs. gap), E52 (= E48), T75 (≠ H71), Q159 (≠ A160), L249 (≠ Y250), E276 (≠ F277), M381 (≠ L363), Q407 (≠ G383), M409 (≠ I385), D434 (= D410), D461 (≠ N437), G463 (≠ A439), Y464 (= Y440), M466 (≠ I442), V467 (≠ L443), Q470 (≠ E446)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1R)-2-fluoro-1-hydroxyethyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: M381 (≠ L363), G382 (≠ P364), S383 (≠ I365), F384 (= F366), Q407 (≠ G383), M409 (≠ I385), G433 (= G409), D434 (= D410), G435 (= G411), D461 (≠ N437), G463 (≠ A439), Y464 (= Y440), N465 (≠ R441)
- binding magnesium ion: S119 (≠ A120), T122 (≠ S123), D434 (= D410), D461 (≠ N437), G463 (≠ A439)
Sites not aligning to the query:
5wdgA Acetolactate synthase from klebsiella pneumoniae in complex with a reaction intermediate
26% identity, 99% coverage: 2:508/512 of query aligns to 7:521/538 of 5wdgA
- active site: I27 (≠ N22), G29 (= G24), A30 (≠ T25), K31 (≠ S26), I32 (vs. gap), E52 (= E48), T75 (≠ H71), Q157 (≠ A160), L246 (≠ Y250), E273 (≠ F277), M378 (≠ L363), Q404 (≠ G383), M406 (≠ I385), D431 (= D410), D458 (≠ N437), G460 (≠ A439), Y461 (= Y440), M463 (≠ I442), V464 (≠ L443), Q467 (≠ E446)
- binding (2S,3S)-2,3-dihydroxy-3-[(7S,8R,9aS)-8-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-2,7-dimethyl-5,7,8,10-tetrahydro-9aH-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin-9a-yl]-2-methylbutanoic acid: M378 (≠ L363), S380 (≠ I365), F381 (= F366), Q404 (≠ G383), M406 (≠ I385), G430 (= G409), D431 (= D410), G432 (= G411), G433 (≠ A412), D458 (≠ N437), G460 (≠ A439), Y461 (= Y440), N462 (≠ R441), M463 (≠ I442), V464 (≠ L443)
- binding magnesium ion: R64 (= R60), S117 (≠ A120), T120 (≠ S123), Q204 (≠ G210), D431 (= D410), D458 (≠ N437), G460 (≠ A439)
- binding pyruvic acid: G94 (≠ F90), R147 (≠ P150)
Sites not aligning to the query:
- active site: 527
- binding (2S,3S)-2,3-dihydroxy-3-[(7S,8R,9aS)-8-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-2,7-dimethyl-5,7,8,10-tetrahydro-9aH-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin-9a-yl]-2-methylbutanoic acid: 527
1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate (see paper)
26% identity, 99% coverage: 2:508/512 of query aligns to 7:532/549 of 1ozgA
- active site: I27 (≠ N22), G29 (= G24), A30 (≠ T25), K31 (≠ S26), I32 (vs. gap), E52 (= E48), T75 (≠ H71), H114 (≠ P110), Q115 (≠ L111), S116 (≠ N112), Q164 (≠ A160), L257 (≠ Y250), E284 (≠ F277), M389 (≠ L363), Q415 (≠ G383), M417 (≠ I385), D442 (= D410), D469 (≠ N437), G471 (≠ A439), Y472 (= Y440), M474 (≠ I442), V475 (≠ L443), Q478 (≠ E446)
- binding 2-hydroxyethyl dihydrothiachrome diphosphate: M389 (≠ L363), G390 (≠ P364), S391 (≠ I365), F392 (= F366), Q415 (≠ G383), M417 (≠ I385), G441 (= G409), D442 (= D410), G443 (= G411), D469 (≠ N437), G471 (≠ A439), Y472 (= Y440), N473 (≠ R441), M474 (≠ I442), V475 (≠ L443)
- binding magnesium ion: D442 (= D410), D469 (≠ N437), G471 (≠ A439)
- binding phosphate ion: G253 (≠ D246), R254 (≠ K247), Q261 (≠ L254), R347 (vs. gap), R398 (≠ T367), Y401 (≠ K370)
Sites not aligning to the query:
5dx6B Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
26% identity, 99% coverage: 2:508/512 of query aligns to 18:535/557 of 5dx6B
- active site: I38 (≠ N22), G40 (= G24), A41 (≠ T25), K42 (≠ S26), I43 (vs. gap), E63 (= E48), T86 (≠ H71), H125 (≠ P110), Q126 (≠ L111), S127 (≠ N112), Q175 (≠ A160), L268 (≠ Y250), E295 (≠ F277), M392 (≠ L363), Q418 (≠ G383), M420 (≠ I385), D445 (= D410), D472 (≠ N437), G474 (≠ A439), Y475 (= Y440), M477 (≠ I442), V478 (≠ L443), Q481 (≠ E446)
- binding 3-fluoro-2-oxopropanoic acid: G264 (≠ D246), R265 (≠ K247), Q272 (≠ L254), A400 (vs. gap), R401 (≠ T367), Y404 (≠ K370)
- binding magnesium ion: S135 (≠ A120), T138 (≠ S123), D445 (= D410), D472 (≠ N437), G474 (≠ A439)
- binding thiamine diphosphate: G393 (≠ P364), S394 (≠ I365), F395 (= F366), Q418 (≠ G383), M420 (≠ I385), G444 (= G409), D445 (= D410), G446 (= G411), D472 (≠ N437), G474 (≠ A439), Y475 (= Y440), N476 (≠ R441), M477 (≠ I442), V478 (≠ L443)
Sites not aligning to the query:
4qq8C Crystal structure of the formolase fls in space group p 43 21 2 (see paper)
25% identity, 100% coverage: 1:512/512 of query aligns to 3:543/569 of 4qq8C
- active site: L24 (≠ N22), G26 (= G24), I27 (≠ T25), H28 (≠ S26), I29 (vs. gap), E49 (= E48), T72 (≠ H71), L111 (vs. gap), Q112 (≠ P110), A113 (≠ L111), G114 (≠ N112), W162 (≠ A160), L255 (≠ K247), T283 (vs. gap), G392 (≠ D357), N418 (≠ S379), M420 (≠ I385), D447 (= D410), N474 (= N437), S476 (≠ A439), W477 (≠ Y440), W479 (≠ L443), T480 (≠ G444), F483 (≠ L447)
- binding magnesium ion: D447 (= D410), N474 (= N437), S476 (≠ A439)
- binding thiamine diphosphate: H25 (≠ P23), E49 (= E48), Q112 (≠ P110), G392 (≠ D357), G393 (≠ A358), L394 (≠ V359), T395 (= T360), N418 (≠ S379), M420 (≠ I385), G446 (= G409), D447 (= D410), G448 (= G411), S449 (≠ A412), Y452 (= Y415), N474 (= N437), S476 (≠ A439), W477 (≠ Y440), G478 (≠ R441), W479 (≠ L443), T480 (≠ G444)
Sites not aligning to the query:
3d7kA Crystal structure of benzaldehyde lyase in complex with the inhibitor mbp (see paper)
25% identity, 100% coverage: 1:512/512 of query aligns to 3:543/554 of 3d7kA
- active site: L24 (≠ N22), G26 (= G24), A27 (≠ T25), H28 (≠ S26), I29 (vs. gap), E49 (= E48), T72 (≠ H71), L111 (vs. gap), Q112 (≠ P110), A113 (≠ L111), G114 (≠ N112), W162 (≠ A160), L255 (≠ K247), T283 (vs. gap), G392 (≠ D357), G418 (= G383), M420 (≠ I385), D447 (= D410), N474 (= N437), S476 (≠ A439), W477 (≠ Y440), A479 (≠ I442), T480 (≠ L443), F483 (≠ L447)
- binding calcium ion: D447 (= D410), N474 (= N437), S476 (≠ A439)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: H25 (≠ P23), G26 (= G24), A27 (≠ T25), E49 (= E48), T72 (≠ H71), Q112 (≠ P110), G392 (≠ D357), A393 (= A358), L394 (≠ V359), T395 (= T360), G418 (= G383), M420 (≠ I385), G446 (= G409), D447 (= D410), G448 (= G411), S449 (≠ A412), Y452 (= Y415), N474 (= N437), S476 (≠ A439), W477 (≠ Y440), G478 (≠ R441), A479 (≠ I442), T480 (≠ L443)
Sites not aligning to the query:
Query Sequence
>CCNA_00397 FitnessBrowser__Caulo:CCNA_00397
MNGADALITTLADNGVTACFANPGTSEMQFVSALDREPRMRSVLCLFEGVATGAADGYGR
MAGKPACTLLHLGPGYANGAANLHNARRAFTPVVNVIGDHATYHRDFDAPLNSDIAALAA
PNSVWVKSAETADSVGPLAAEAIIAAYGTPGGNACLVLPADAAWNEATVKGPMVTPPAFA
APDAASVEAVAKALGGATKPVLLLGSGACGEAALAAAGRLAAHGVRVLTDTFTARQARGE
GRFRPDKLPYFGELALKDLDGVDLIVLVATQTPVAFFAYPDRPSVLVPEGCSVETLCGRE
VDAAAALNALADALGAPAAGPVETYAAPDAPAGRLDAWAIGAAIARHMPTDTIISDDAVT
AGLPIFTQTKAARAHDWLSLTGGAIGQGIPLAIGAAVACPDRKVLALTGDGAGMYTVQGL
WTVVREKLDVTVVVFANHAYRILGIELGRTGAGNPGPAAAKLLDLGDPRIDWVKLAEGLG
MAAERVATAEAFEEAFARAMATPGPRLIEAAM
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory