Comparing Dsui_2735 FitnessBrowser__PS:Dsui_2735 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3a8iA Crystal structure of et-ehred-5-ch3-thf complex (see paper)
54% identity, 99% coverage: 3:363/363 of query aligns to 2:363/363 of 3a8iA
1worA Crystal structure of t-protein of the glycine cleavage system (see paper)
43% identity, 98% coverage: 3:357/363 of query aligns to 2:357/362 of 1worA
1wopA Crystal structure of t-protein of the glycine cleavage system (see paper)
43% identity, 98% coverage: 3:357/363 of query aligns to 2:357/362 of 1wopA
Sites not aligning to the query:
1wooA Crystal structure of t-protein of the glycine cleavage system (see paper)
43% identity, 98% coverage: 3:357/363 of query aligns to 2:357/362 of 1wooA
Sites not aligning to the query:
P48728 Aminomethyltransferase, mitochondrial; Glycine cleavage system T protein; GCVT; EC 2.1.2.10 from Homo sapiens (Human) (see 4 papers)
35% identity, 97% coverage: 3:355/363 of query aligns to 34:394/403 of P48728
Sites not aligning to the query:
1wsvA Crystal structure of human t-protein of glycine cleavage system (see paper)
35% identity, 97% coverage: 3:355/363 of query aligns to 3:363/371 of 1wsvA
Sites not aligning to the query:
3ad7A Heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with methylthio acetate (see paper)
30% identity, 96% coverage: 3:350/363 of query aligns to 574:949/963 of 3ad7A
Sites not aligning to the query:
1vrqA Crystal structure of heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with folinic acid (see paper)
30% identity, 96% coverage: 3:350/363 of query aligns to 574:949/963 of 1vrqA
Sites not aligning to the query:
Q50LF0 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain U-96) (see 2 papers)
30% identity, 96% coverage: 3:350/363 of query aligns to 575:950/965 of Q50LF0
Sites not aligning to the query:
2gagA Heteroteterameric sarcosine: structure of a diflavin metaloenzyme at 1.85 a resolution (see paper)
28% identity, 97% coverage: 5:355/363 of query aligns to 577:955/965 of 2gagA
Sites not aligning to the query:
Q46337 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain P-1) (see 2 papers)
28% identity, 95% coverage: 5:350/363 of query aligns to 579:952/967 of Q46337
Sites not aligning to the query:
Q9AGP8 Dimethylglycine oxidase; DMGO; EC 1.5.3.10 from Arthrobacter globiformis (see 2 papers)
26% identity, 95% coverage: 11:355/363 of query aligns to 439:821/830 of Q9AGP8
Sites not aligning to the query:
1pj6A Crystal structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folic acid (see paper)
26% identity, 95% coverage: 11:355/363 of query aligns to 437:819/828 of 1pj6A
Sites not aligning to the query:
1pj7A Structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folinic acid (see paper)
26% identity, 95% coverage: 11:355/363 of query aligns to 436:818/827 of 1pj7A
Sites not aligning to the query:
Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 2 papers)
27% identity, 91% coverage: 24:352/363 of query aligns to 507:837/857 of Q63342
Sites not aligning to the query:
4pabB Crystal structure of the precursor form of rat dmgdh complexed with tetrahydrofolate (see paper)
27% identity, 91% coverage: 24:352/363 of query aligns to 470:800/824 of 4pabB
Sites not aligning to the query:
3gsiA Crystal structure of d552a dimethylglycine oxidase mutant of arthrobacter globiformis in complex with tetrahydrofolate (see paper)
26% identity, 95% coverage: 11:355/363 of query aligns to 436:818/827 of 3gsiA
Sites not aligning to the query:
Q9UI17 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Homo sapiens (Human) (see 4 papers)
27% identity, 91% coverage: 24:352/363 of query aligns to 514:844/866 of Q9UI17
Sites not aligning to the query:
Q8GAI3 4-methylaminobutanoate oxidase (formaldehyde-forming); MABO; Demethylating gamma-N-methylaminobutyrate oxidase; Gamma-N-methylaminobutyrate oxidase 1; EC 1.5.3.19 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see paper)
26% identity, 88% coverage: 35:355/363 of query aligns to 489:814/824 of Q8GAI3
Sites not aligning to the query:
3tfjA Dmsp-dependent demethylase from p. Ubique - with cofactor thf (see paper)
22% identity, 83% coverage: 26:327/363 of query aligns to 37:339/369 of 3tfjA
Sites not aligning to the query:
>Dsui_2735 FitnessBrowser__PS:Dsui_2735
MTKQTVLNKAHRALNARMVDFGGWDMPVNYGSQIEEHHAVRNDCGMFDVSHMCAVDVTGA
DAKAFLLRLIANNVDKLKVPGKALYSAMLNEAGGVVDDLIVYYLTDTHYRVVINAGTADK
DLAWMDQLLGQWQLDVSVIPLREGPKAVAMIAVQGPQAKAKVWQVLPEVKAATKNLAPFF
GTQIGQFFIATTGYTGEDGFEIALPAAKAEDFWNALIAAGVRPCGLGARDTLRLEAGMNL
YGQDMDETVSPLDAGLAWTVDLKSERDFVGKSALLANGQKAQFLGLKLLDKGVLRAHQKV
VTSQGEGEITSGTFSPTLEQSIALARLPLGVAIGDTVQVDIRGKLLNAQVVKPVFARHGK
AVA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory