Comparing Echvi_1891 FitnessBrowser__Cola:Echvi_1891 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9VLJ8 Adenylyltransferase and sulfurtransferase MOCS3; Molybdenum cofactor synthesis protein 3; Ubiquitin activating enzyme 4; EC 2.7.7.80; EC 2.8.1.11 from Drosophila melanogaster (Fruit fly) (see paper)
37% identity, 97% coverage: 4:353/360 of query aligns to 70:441/453 of Q9VLJ8
Sites not aligning to the query:
O59954 Adenylyltransferase and sulfurtransferase uba4; Common component for nitrate reductase and xanthine dehydrogenase protein F; Ubiquitin-like protein activator 4; EC 2.7.7.80; EC 2.8.1.11 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
34% identity, 99% coverage: 5:359/360 of query aligns to 68:479/482 of O59954
O95396 Adenylyltransferase and sulfurtransferase MOCS3; Molybdenum cofactor synthesis protein 3; Molybdopterin synthase sulfurylase; MPT synthase sulfurylase; EC 2.7.7.80; EC 2.8.1.11 from Homo sapiens (Human) (see 5 papers)
35% identity, 98% coverage: 5:357/360 of query aligns to 62:452/460 of O95396
Sites not aligning to the query:
Q72J02 Sulfur carrier protein adenylyltransferase; E1-like protein TtuC; Sulfur carrier protein MoaD adenylyltransferase; Sulfur carrier protein ThiS adenylyltransferase; Sulfur carrier protein TtuB adenylyltransferase; tRNA two-thiouridine-synthesizing protein C; EC 2.7.7.80; EC 2.7.7.73; EC 2.7.7.- from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
48% identity, 65% coverage: 5:238/360 of query aligns to 10:248/271 of Q72J02
Sites not aligning to the query:
6yubA Crystal structure of uba4 from chaetomium thermophilum (see paper)
31% identity, 98% coverage: 5:357/360 of query aligns to 13:415/423 of 6yubA
P38820 Adenylyltransferase and sulfurtransferase UBA4; Needs CLA4 to survive protein 3; Ubiquitin-like protein activator 4; EC 2.7.7.-; EC 2.8.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
30% identity, 96% coverage: 5:350/360 of query aligns to 46:425/440 of P38820
P12282 Molybdopterin-synthase adenylyltransferase; MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase; Sulfur carrier protein MoaD adenylyltransferase; EC 2.7.7.80 from Escherichia coli (strain K12) (see 2 papers)
41% identity, 61% coverage: 5:224/360 of query aligns to 11:229/249 of P12282
Sites not aligning to the query:
D4GSF3 SAMP-activating enzyme E1; Ubiquitin-like activating enzyme of archaea; Ubl-activating enzyme; EC 2.7.7.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
42% identity, 65% coverage: 5:238/360 of query aligns to 12:244/270 of D4GSF3
1jwbB Structure of the covalent acyl-adenylate form of the moeb-moad protein complex (see paper)
40% identity, 61% coverage: 5:224/360 of query aligns to 10:221/240 of 1jwbB
Sites not aligning to the query:
1jw9B Structure of the native moeb-moad protein complex (see paper)
40% identity, 61% coverage: 5:224/360 of query aligns to 10:221/240 of 1jw9B
Sites not aligning to the query:
6yubB Crystal structure of uba4 from chaetomium thermophilum (see paper)
41% identity, 57% coverage: 5:208/360 of query aligns to 14:213/289 of 6yubB
Sites not aligning to the query:
1zfnA Structural analysis of escherichia coli thif (see paper)
44% identity, 61% coverage: 5:222/360 of query aligns to 8:223/244 of 1zfnA
Sites not aligning to the query:
P30138 Sulfur carrier protein ThiS adenylyltransferase; EC 2.7.7.73 from Escherichia coli (strain K12) (see 3 papers)
44% identity, 61% coverage: 5:222/360 of query aligns to 8:223/251 of P30138
Sites not aligning to the query:
1zud3 Structure of this-thif protein complex (see paper)
43% identity, 61% coverage: 5:222/360 of query aligns to 8:218/240 of 1zud3
Sites not aligning to the query:
1jwaB Structure of the atp-bound moeb-moad protein complex (see paper)
37% identity, 61% coverage: 5:224/360 of query aligns to 10:206/217 of 1jwaB
Q7SXG4 SUMO-activating enzyme subunit 2; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2; EC 2.3.2.- from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
33% identity, 42% coverage: 17:168/360 of query aligns to 10:162/650 of Q7SXG4
Sites not aligning to the query:
3h5rA Crystal structure of e. Coli mccb + succinimide (see paper)
34% identity, 39% coverage: 4:144/360 of query aligns to 90:235/340 of 3h5rA
Sites not aligning to the query:
3h5aC Crystal structure of e. Coli mccb (see paper)
34% identity, 39% coverage: 4:144/360 of query aligns to 90:235/358 of 3h5aC
Sites not aligning to the query:
3h5nA Crystal structure of e. Coli mccb + atp (see paper)
34% identity, 39% coverage: 4:144/360 of query aligns to 90:235/338 of 3h5nA
Sites not aligning to the query:
3h9jA Crystal structure of e. Coli mccb + ampcpp + semet mcca (see paper)
34% identity, 39% coverage: 4:144/360 of query aligns to 90:235/339 of 3h9jA
Sites not aligning to the query:
>Echvi_1891 FitnessBrowser__Cola:Echvi_1891
MNETRYQKQIRLKSFGKQSQDKLASSSVLIIGAGGLGTPVAQYLNGVGVGTLAIMDQDTV
AESNLARQTLFTPEDVGKHKTDVLIQYLRRQNPSTRFINVREFLTPVNALQELADYDLIV
DASDNFGTRYLVNDACVMLDKPFIYGALHEFEGQVSVMNYQNGPTYRCLFPEVGDPSAIL
NCDENGVLGILPGLIGTYQALEAVKVLTGIGEPLAGKLLIIDTLAQTHLKVGLTSVPENQ
SIRKLQENYGQPMCSTDLPVTSLTCEEFWSKREGDSQHQIIDVRNEGEFDSGHLDSAQNI
PLSQLTERHQEINEKAPVILICQSGKRSLQAAQLLQSLHPEQIIYNLEGGMNALEAEDWK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory