SitesBLAST
Comparing GFF1383 FitnessBrowser__Phaeo:GFF1383 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P00944 Xylose isomerase; D-xylulose keto-isomerase; EC 5.3.1.5 from Escherichia coli (strain K12) (see paper)
59% identity, 100% coverage: 1:434/434 of query aligns to 1:437/440 of P00944
1a0eA Xylose isomerase from thermotoga neapolitana
47% identity, 100% coverage: 2:434/434 of query aligns to 1:435/443 of 1a0eA
- active site: H100 (= H98), D103 (= D101), W138 (= W136), E231 (= E229), K233 (= K231), E267 (= E265), H270 (= H268), D295 (= D293), D306 (= D304), D308 (= D306), D338 (= D336)
- binding cobalt (ii) ion: E231 (= E229), E267 (= E265), E267 (= E265), H270 (= H268), D295 (= D293), D308 (= D306), D338 (= D336)
1a0cA Xylose isomerase from thermoanaerobacterium thermosulfurigenes
46% identity, 99% coverage: 4:434/434 of query aligns to 3:435/437 of 1a0cA
- active site: H100 (= H98), D103 (= D101), W138 (= W136), E231 (= E229), K233 (= K231), E267 (= E265), H270 (= H268), D295 (= D293), D306 (= D304), D308 (= D306), D338 (= D336)
- binding cobalt (ii) ion: E231 (= E229), E267 (= E265), E267 (= E265), H270 (= H268), D295 (= D293), D306 (= D304), D308 (= D306), D338 (= D336)
1a0dA Xylose isomerase from bacillus stearothermophilus
48% identity, 99% coverage: 4:434/434 of query aligns to 2:433/437 of 1a0dA
- active site: H98 (= H98), D101 (= D101), W136 (= W136), E229 (= E229), K231 (= K231), E265 (= E265), H268 (= H268), D293 (= D293), D304 (= D304), D306 (= D306), D336 (= D336)
- binding manganese (ii) ion: E229 (= E229), E265 (= E265), E265 (= E265), H268 (= H268), D293 (= D293), D304 (= D304), D306 (= D306), D336 (= D336)
5nhcA Crystal structure of xylose isomerase from piromyces e2 in complex with two co2+ ions and xylulose (see paper)
48% identity, 98% coverage: 4:430/434 of query aligns to 4:432/436 of 5nhcA
- active site: H101 (= H98), D104 (= D101), W139 (= W136), E232 (= E229), K234 (= K231), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding cobalt (ii) ion: E232 (= E229), E268 (= E265), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding 4-hydroxyproline: G290 (= G287), L292 (≠ F289), G328 (= G325), G330 (= G327), V332 (≠ K329)
- binding d-xylulose: W49 (= W47), H101 (= H98), W188 (= W185), E232 (= E229), E268 (= E265), H271 (= H268), D339 (= D336)
5nhaA Crystal structure of xylose isomerase from piromyces sp. E2 in complex with two mn2+ ions and sorbitol (see paper)
48% identity, 98% coverage: 4:430/434 of query aligns to 4:432/436 of 5nhaA
- active site: H101 (= H98), D104 (= D101), W139 (= W136), E232 (= E229), K234 (= K231), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding manganese (ii) ion: E232 (= E229), E268 (= E265), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding sorbitol: W49 (= W47), H101 (= H98), W188 (= W185), E232 (= E229), D339 (= D336)
5nh9A Crystal structure of xylose isomerase from piromyces e2 in complex with two mn2+ ions and xylose (see paper)
48% identity, 98% coverage: 4:430/434 of query aligns to 4:432/436 of 5nh9A
- active site: H101 (= H98), D104 (= D101), W139 (= W136), E232 (= E229), K234 (= K231), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding manganese (ii) ion: E232 (= E229), E268 (= E265), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding D-xylose: W49 (= W47), H101 (= H98), W188 (= W185), E232 (= E229), E268 (= E265), H271 (= H268), D339 (= D336)
- binding beta-D-xylopyranose: G63 (≠ Q61), K65 (≠ F63), S66 (≠ Q64), K203 (≠ S200), K206 (≠ L203), H257 (≠ F254), D288 (≠ A285), A289 (≠ L286)
5nh7A Crystal structure of xylose isomerase from piromyces e2 in complex with two mg2+ ions and xylose (see paper)
48% identity, 98% coverage: 4:430/434 of query aligns to 4:432/436 of 5nh7A
- active site: H101 (= H98), D104 (= D101), W139 (= W136), E232 (= E229), K234 (= K231), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding magnesium ion: E232 (= E229), E268 (= E265), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding D-xylose: W49 (= W47), H101 (= H98), W188 (= W185), E232 (= E229), E268 (= E265), H271 (= H268), D339 (= D336)
- binding beta-D-xylopyranose: G63 (≠ Q61), K65 (≠ F63), S66 (≠ Q64)
- binding alpha-D-xylopyranose: P21 (vs. gap), D40 (= D38), Y97 (= Y94), K136 (= K133), E350 (= E347)
5nh6A Crystal structure of xylose isomerase from piromyces e2 complexed with one mg2+ ion and xylitol (see paper)
48% identity, 98% coverage: 4:430/434 of query aligns to 4:432/436 of 5nh6A
- active site: H101 (= H98), D104 (= D101), W139 (= W136), E232 (= E229), K234 (= K231), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding magnesium ion: E232 (= E229), E268 (= E265), D296 (= D293), D339 (= D336)
- binding Xylitol: W49 (= W47), H101 (= H98), W188 (= W185), E232 (= E229), E268 (= E265), H271 (= H268), D339 (= D336)
5nh5A Crystal structure of native xylose isomerase from piromyces e2 (see paper)
48% identity, 98% coverage: 4:430/434 of query aligns to 4:432/436 of 5nh5A
- active site: H101 (= H98), D104 (= D101), W139 (= W136), E232 (= E229), K234 (= K231), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding calcium ion: E232 (= E229), E268 (= E265), D296 (= D293), D339 (= D336)
- binding fe (ii) ion: E232 (= E229), E268 (= E265), D296 (= D293), D339 (= D336)
- binding magnesium ion: E232 (= E229), E268 (= E265), D296 (= D293), D339 (= D336)
5nh4A Crystal structure of xylose isomerase from piromyces e2 in complex with one mg2+ ions and glycerol (see paper)
48% identity, 98% coverage: 4:430/434 of query aligns to 4:432/436 of 5nh4A
- active site: H101 (= H98), D104 (= D101), W139 (= W136), E232 (= E229), K234 (= K231), E268 (= E265), H271 (= H268), D296 (= D293), D307 (= D304), D309 (= D306), D339 (= D336)
- binding magnesium ion: E232 (= E229), E268 (= E265), D296 (= D293), D339 (= D336)
5yn3A Crystal structure of xylose isomerase from piromyces sp. E2 (see paper)
48% identity, 98% coverage: 4:430/434 of query aligns to 3:431/435 of 5yn3A
- active site: H100 (= H98), D103 (= D101), W138 (= W136), E231 (= E229), K233 (= K231), E267 (= E265), H270 (= H268), D295 (= D293), D306 (= D304), D308 (= D306), D338 (= D336)
- binding glycerol: H100 (= H98), W187 (= W185), E231 (= E229), D295 (= D293)
- binding manganese (ii) ion: E231 (= E229), E267 (= E265), E267 (= E265), H270 (= H268), D295 (= D293), D306 (= D304), D308 (= D306), D338 (= D336)
4xkmA Crystal structure of xylose isomerase from an human intestinal tract microbe bacteroides thetaiotaomicron
49% identity, 99% coverage: 4:434/434 of query aligns to 3:435/435 of 4xkmA
- active site: F23 (≠ Y22), E29 (≠ D28), H100 (= H98), D103 (= D101), W138 (= W136), E231 (= E229), K233 (= K231), E267 (= E265), H270 (= H268), D295 (= D293), D306 (= D304), D308 (= D306), D338 (= D336)
- binding manganese (ii) ion: E231 (= E229), E267 (= E265), E267 (= E265), H270 (= H268), D295 (= D293), D306 (= D304), D308 (= D306), D338 (= D336)
6intA Xylose isomerase from paenibacillus sp. R4 (see paper)
44% identity, 99% coverage: 4:434/434 of query aligns to 1:410/413 of 6intA
- active site: H74 (= H98), D77 (= D101), W112 (= W136), E205 (= E229), K207 (= K231), E241 (= E265), H244 (= H268), D269 (= D293), D280 (= D304), D282 (= D306), D313 (= D336)
- binding calcium ion: G166 (= G190), E178 (= E202), E205 (= E229), E241 (= E265), E241 (= E265), H244 (= H268), D269 (= D293), D280 (= D304), D282 (= D306), D313 (= D336)
4j4kA Crystal structure of glucose isomerase
31% identity, 86% coverage: 41:414/434 of query aligns to 8:368/385 of 4j4kA
- active site: H52 (= H98), D55 (= D101), M86 (≠ W136), E179 (= E229), K181 (= K231), E215 (= E265), H218 (= H268), D243 (= D293), D253 (= D306), D255 (vs. gap), D285 (= D336)
- binding zinc ion: E179 (= E229), E215 (= E265), E215 (= E265), H218 (= H268), D243 (= D293), D253 (= D306), D255 (vs. gap), D285 (= D336)
1oadA Glucose isomerase from streptomyces rubiginosus in p21212 crystal form (see paper)
31% identity, 86% coverage: 41:414/434 of query aligns to 9:369/387 of 1oadA
- active site: H53 (= H98), D56 (= D101), M87 (≠ W136), E180 (= E229), K182 (= K231), E216 (= E265), H219 (= H268), D244 (= D293), D254 (= D306), D256 (vs. gap), D286 (= D336)
- binding magnesium ion: E180 (= E229), E216 (= E265), D244 (= D293), D286 (= D336)
- binding manganese (ii) ion: E216 (= E265), H219 (= H268), D254 (= D306), D256 (vs. gap)
- binding 2-methylpentane-1,2,4-triol: W15 (= W47), H53 (= H98), F93 (= F142), W136 (= W185), E180 (= E229), D286 (= D336)
5y4iA Crystal structure of glucose isomerase in complex with glycerol in one metal binding mode (see paper)
31% identity, 86% coverage: 41:414/434 of query aligns to 8:368/384 of 5y4iA
- active site: H52 (= H98), D55 (= D101), M86 (≠ W136), E179 (= E229), K181 (= K231), E215 (= E265), H218 (= H268), D243 (= D293), D253 (= D306), D255 (vs. gap), D285 (= D336)
- binding glycerol: H52 (= H98), W135 (= W185), E179 (= E229), D285 (= D336)
- binding magnesium ion: E179 (= E229), E215 (= E265), D243 (= D293), D285 (= D336)
8awsA Millisecond cryo-trapping by the spitrobot crystal plunger, xylose isomerase with glucose at 50ms (see paper)
31% identity, 86% coverage: 41:414/434 of query aligns to 9:369/386 of 8awsA
- binding beta-D-glucopyranose: H53 (= H98), T89 (= T138), W136 (= W185), E180 (= E229), D286 (= D336)
- binding magnesium ion: E180 (= E229), E216 (= E265), D244 (= D293), D286 (= D336)
- binding manganese (ii) ion: E216 (= E265), H219 (= H268), D254 (= D306), D256 (vs. gap)
3u3hA X-ray crystallographic analysis of d-xylose isomerase-catalyzed isomerization of (r)-glyceraldehyde (see paper)
31% identity, 86% coverage: 41:414/434 of query aligns to 9:369/386 of 3u3hA
- active site: H53 (= H98), D56 (= D101), M87 (≠ W136), E180 (= E229), K182 (= K231), E216 (= E265), H219 (= H268), D244 (= D293), D254 (= D306), D256 (vs. gap), D286 (= D336)
- binding (2R)-propane-1,1,2,3-tetrol: H53 (= H98), W136 (= W185), E180 (= E229), D286 (= D336)
- binding magnesium ion: E180 (= E229), E216 (= E265), E216 (= E265), H219 (= H268), D244 (= D293), D254 (= D306), D256 (vs. gap), D286 (= D336)
2g4jA Anomalous substructure of glucose isomerase (see paper)
31% identity, 86% coverage: 41:414/434 of query aligns to 9:369/386 of 2g4jA
- active site: H53 (= H98), D56 (= D101), M87 (≠ W136), E180 (= E229), K182 (= K231), E216 (= E265), H219 (= H268), D244 (= D293), D254 (= D306), D256 (vs. gap), D286 (= D336)
- binding calcium ion: E216 (= E265), H219 (= H268), D254 (= D306), D256 (vs. gap)
- binding chloride ion: A200 (≠ G249), R204 (= R253)
- binding magnesium ion: E180 (= E229), E216 (= E265), D244 (= D293), D286 (= D336)
Query Sequence
>GFF1383 FitnessBrowser__Phaeo:GFF1383
MAGYFDDIAAITYNPESDRLAYRHYNPDEMIMGKRMEDHLRFAVCYWHNFVWEGNDPFGG
QTFQRPWFPADTMDLARMKADAAFDMFRILGVPYYCFHDHDIRPEGASLAESHKRLNQIG
DLLEQKMADGGPKLLWGTANMFSNRRYMSGASTNPDPDVFAYCASTVRACMDLTHRLNGE
NYVLWGGREGYETLLNTDLSRELEQMGRFLSMVVDYKHKIGFMGAILIEPKPQEPTKHQY
DYDVATVYGFLKRFGLEEEVKVNIEQGHAILAGHSFEHEIAMANALGIFGSIDMNRNDYQ
SGWDTDQFPNNVPEVALAYYEILRGGGLKTGGTNFDAKLRRQSLDAEDLIAAHVGAMDVC
ARGLRAAAAMLESDSLEAKRRDRYAGWTTAEAQAYLAEGATLEAIADQAEARALNPQPVS
GRQEQLEALVNRFV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory